Now showing items 1-10 of 28

    • Abnormal expression of MDM2 in prostate carcinoma 

      Leite, Katia Ramos Moreira [UNIFESP]; Franco, Marcello Fabiano de [UNIFESP]; Srougi, Miguel [UNIFESP]; Nesrallah, Luciano J.; Nesrallah, Adriano; Bevilacqua, Ruy G.; Darini, Elaine; Carvalho, Claudia M.; Meirelles, Maria Ines; Santana, Isaque; Camara-Lopes, L. H. (Lippincott Williams & Wilkins, 2001-05-01)
      Mutation of p53 is rare in localized prostate carcinoma the oncoprotein MDM2, whose gene has a response element for p53, promotes the degradation of p53 protein and inhibits its transcriptional activation of genes related ...

    • Adrenocorticotropin-producing pituitary carcinoma with expression of c-erbB-2 and high PCNA index: A comparative study with pituitary adenomas and normal pituitary tissues 

      Nose-Alberti, V; Mesquita, MIS; Martin, L. C.; Kayath, M. J. (Humana Press Inc, 1998-03-01)
      Pituitary carcinomas are very rare neoplasms with a poor prognosis. We report a case of Cushing's disease resulting from a pituitary carcinoma in a ZZ-yr-old female, who died of massive hepatic failure. At autopsy, there ...

    • Analysis of p53 expression and proliferative assessment using PCNA in localized prostate carcinoma 

      Leite, Kátia Ramos Moreira [UNIFESP]; Srougi, Miguel [UNIFESP]; Nesrallah, Luciano João [UNIFESP]; Camara-Lopes, Luiz H [UNIFESP] (Associação Brasileira de Divulgação Científica, 1999-03-01)
      The surgical specimens from 51 men submitted to radical prostatectomy for localized prostate cancer were examined by immunohistochemistry using proliferation cell nuclear antigen (PCNA) monoclonal antibody to evaluate the ...

    • Análise do tempo de sobrevida de doentes com adenocarcinoma colorretal esporádico pela utilização de um painel de biomarcadores de carcinogênese constituído por vegf, egfr, ki-67, p53 e bcl-2 

      Luderer, Loreley Andrade [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2014-12-17)
      Objective: To evaluate the prognostic power of survival of a carcinogenesis biomarkers panel formed by p53, VEGF, Bcl-2, Ki-67, and EGFR in subjects with sporadic colorectal adenocarcinoma subjected to radical surgical ...

    • Apoptosis, PCNA and p53 in hepatocellular carcinoma 

      Paiva, C.; Oshima, Celina Tizuko Fujiyama [UNIFESP]; Lanzoni, Valeria Pereira [UNIFESP]; Forones, Nora Manoukian [UNIFESP] (H G E Update Medical Publishing S A, 2002-07-01)
      Background/Aims: The regulation of cell number is present in normal tissues but is lost in malignant neoplasms. The real :meaning of these alterations is not well known. Apoptosis is the programmed cell death. p53, a tumor ...

    • Ascorbic acid prevents acute myocardial infarction induced by isoproterenol in rats: role of inducible nitric oxide synthase production 

      Ribeiro, Daniel Araki [UNIFESP]; Buttros, Juliana Beatriz [UNIFESP]; Oshima, Celina Tizuko Fujiyama [UNIFESP]; Bergamaschi, Cassia Toledo [UNIFESP]; Campos, Ruy Ribeiro [UNIFESP] (Springer, 2009-04-01)
      The goal of this study was to investigate whether sub-chronic anti-oxidant treatment with ascorbic acid (Vit C) is able to protect the heart against myocardial infarction. the effects of Vit C treatment on the histopatological ...

    • Avaliação da proliferação celular e apoptose em células da mucosa bucal de ratos expostos ao decanoato de nandrolona 

      Pozzi, Renan [UNIFESP] (Universidade Federal de São Paulo, 2012-12-03)
      Objetivo: Verificar a interferência do decanoato de nandrolona em proteínas regulatórias relacionadas à proliferação celular, apoptose e COX-2 em células da mucosa bucal de ratos Wistar. Metodologia: Um total de 40 ratos ...

    • Cell-Cycle Analysis and Apoptosis-associated Proteins in Cervical Lesions of Brazilian Women 

      Dobo, Cristine [UNIFESP]; Oshima, Celina Tizuko Fujiyama [UNIFESP]; Lima, Flavio de Oliveira [UNIFESP]; Gomes, Thiago Simao [UNIFESP]; Stavale, Joao Norberto [UNIFESP]; Arias, Vitor [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP]; Focchi, Gustavo Rubino de Azevedo [UNIFESP] (Int Inst Anticancer Research, 2014-06-01)
      Aim: The aim of the present study was to detect the relative expressions of p53, p21(Waf1/Cip1), p27(Kip1) Bcl-2 and cleaved caspase-3 in cervical lesion samples from Brazilian women by immunohistochemistry. Materials and ...

    • Clinical significance of c-myc and p53 expression in head and neck squamous cell carcinomas 

      Waitzberg, AFL; Nonogaki, S.; Nishimoto, L. N.; Kowalski, L. P.; Miguel, R. E.; Brentani, R. R.; Brentani, M. M. (Elsevier B.V., 2004-01-01)
      c-myc and p53 genes were frequently deregulated in head and neck squamous cell carcinoma (HNSCC). To determine if the concomitant expression of the two oncogenes might have prognostic value, the survival and free disease ...

    • Comparative study of the expression of cellular cycle proteins in cervical intraepithelial lesions 

      Queiroz, Conceicao; Silva, Tania Correia; Alves, Venancio A. F.; Villa, Luisa L.; Costa, Maria Cecilia; Travassos, Ana Gabriela; Araujo, Jose Bouzas; Studart, Eduardo; Cheto, Tatiana; Freitas, Luiz Antonio R. de (Elsevier B.V., 2006-01-01)
      Interaction of human papilloma virus oncoproteins E6 and E7 with cell cycle proteins leads to disturbances of the cell cycle mechanism and subsequent alteration in the expression of some proteins, such as p16(INK4a), cyclin ...