Browsing by Subject "neurodegeneration"

Now showing items 1-10 of 10

    • CCP1/Nna1 functions in protein turnover in mouse brain: Implications for cell death in Purkinje cell degeneration mice 

      Berezniuk, Iryna; Sironi, Juan; Callaway, Myrasol B.; Castro, Leandro M.; Hirata, Izaura Y. [UNIFESP]; Ferro, Emer S.; Fricker, Lloyd D. (Federation Amer Soc Exp Biol, 2010-06-01)
      Purkinje cell degeneration (pcd) mice have a mutation within the gene encoding cytosolic carboxypeptidase 1 (CCP1/Nna1), which has homology to metallocarboxypeptidases. To assess the function of CCP1/Nna1, quantitative ...

    • Characterization of reactive astrocytes in the chronic phase of the pilocarpine model of epilepsy 

      Garzillo, Cibele Larrosa [UNIFESP]; Mello, Luiz Eugenio Araujo de Moraes [UNIFESP] (Blackwell Publishing Inc, 2002-01-01)
      Purpose: Astrogliosis is a prominent finding in human temporal lobe epilepsy. Work in animal models of temporal lobe epilepsy, however, have mostly concentrated on the acute phases of the studied models or have failed to ...

    • Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux 

      Luz, Marcio Henrique Mello da [UNIFESP]; Peres, Italo T. [UNIFESP]; Santos, Tiago G.; Martins, Vilma R.; Icimoto, Marcelo Yudi [UNIFESP]; Lee, Kil Sun [UNIFESP] (Frontiers Research Foundation, 2015-02-02)
      Accumulation of protein aggregates is a histopathological hallmark of several neurodegenerative diseases, but in most cases the aggregation occurs without defined mutations or clinical histories, suggesting that certain ...

    • Increase in bax expression and apoptosis are associated in Huntington's disease progression 

      Teles, A. V. F. F. [UNIFESP]; Rosenstock, T. R. [UNIFESP]; Okuno, C. S. [UNIFESP]; Lopes, G. S. [UNIFESP]; Bertoncini, C. R. A. [UNIFESP]; Smaili, Soraya Soubhi [UNIFESP] (Elsevier B.V., 2008-06-13)
      Huntington's disease (HD) is a hereditary dominant neurodegenerative disorder and the progression of the disease may be associated with apoptosis and altered expression of apoptotic proteins. the aim of this study was to ...

    • Lithium-methomyl induced seizures in rats: A new model of status epilepticus? 

      Kaminski, Rafal M.; Blaszczak, Piotr; Dekundy, Andrzej; Parada-Turska, Jolanta; Calderazzo, Lineu; Cavalheiro, Esper A.; Turski, Waldemar A. (Elsevier B.V., 2007-03-01)
      Behavioral, electroencephalographic (EEG) and neuropathological effects of methomyl, a carbamate insecticide reversibly inhibiting acetylcholinesterase activity, were studied in naive or lithium chloride (24 h, 3 mEq/kg, ...

    • Metformin: Repurposing Opportunities for Cognitive and Mood Dysfunction 

      Ying, Melissa A.; Maruschak, Nadia; Mansur, Rodrigo Barbachan [UNIFESP]; Carvalho, Andre F.; Cha, Danielle S.; McIntyre, Roger S. (Bentham Science Publ Ltd, 2014-01-01)
      Background: Cognitive deficits differentially affect individuals with type 2 diabetes mellitus (T2DM) and mood disorders. Accumulating evidence implicates disturbances in metabolism as salient to cognitive function. Thus, ...

    • Methylmalonate impairs mitochondrial respiration supported by NADH-linked substrates: Involvement of mitochondrial glutamate metabolism 

      Melo, Daniela R.; Mirandola, Sandra R.; Assuncao, Nilson A. [UNIFESP]; Castilho, Roger F. (Wiley-Blackwell, 2012-06-01)
      The neurodegeneration that occurs in methylmalonic acidemia is proposed to be associated with impairment of mitochondrial oxidative metabolism resulting from methylmalonate (MMA) accumulation. the present study evaluated ...

    • Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid 

      Rosenstock, Tatiana Rosado [UNIFESP]; Carvalho, Ana Carolina Pereira de [UNIFESP]; Jurkiewicz, Aron [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]; Smaili, Soraya Soubhi [UNIFESP] (Blackwell Publishing Ltd, 2004-03-01)
      Intracellular calcium homeostasis is important for cell survival. However, increase in mitochondrial calcium (Ca-m(2+)) induces opening of permeability transition pore (PTP), mitochondrial dysfunction and apoptosis. Since ...

    • Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy 

      Oliveira-Giacomelli, Agatha; Naaldijk, Yahaira; Sarda-Arroyo, Laura; Goncalves, Maria C. B. [UNIFESP]; Correa-Velloso, Juliana; Pillat, Micheli M.; Souza, Hellio D. N. de; Ulrich, Henning (Frontiers Media Sa, 2018)
      Since proving adenosine triphosphate (ATP) functions as a neurotransmitter in neuron/glia interactions, the purinergic system has been more intensely studied within the scope of the central nervous system. In neurological ...

    • THIAMINE DEFICIENCY in VITRO ACCELERATES A-TYPE POTASSIUM CURRENT INACTIVATION in CEREBELLAR GRANULE NEURONS 

      Cruz, J. S.; Kushmerick, C.; Moreira-Lobo, D. C.; Oliveira, F. A. [UNIFESP] (Elsevier B.V., 2012-09-27)
      Thiamine deficiency during embryonic or early postnatal development causes deficits in cerebellum-dependent activities including motor control and procedural memory. Here, we give a detailed description of the changes to ...