Now showing items 1-7 of 7

    • Dendritic cell subset expression in severe chronic rhinosinusitis with nasal polyps 

      Perez-Novo, Claudina; Pezato, Rogerio [UNIFESP] (Lippincott Williams & Wilkins, 2017)
      Purpose of review Two main pillars are implicated in nasal polyposis development: a severe imbalance in immunomodulation and a mechanical dysfunction because of an abnormal remodeling process. Dendritic cells play a crucial ...

    • Evaluating budesonide efficacy in nasal polyposis and predicting the resistance to treatment 

      Valera, F. C. P.; Queiroz, R.; Scrideli, C.; Tone, L. G.; Anselmo-Lima, W. T. (Wiley-Blackwell, 2009-01-01)
      Cell resistance to glucocorticoids is a major problem in the treatment of nasal polyposis (NP).The objectives of this study were to observe the effect of budesonide on the expression of IL-1 beta, TNF-alpha, granulocyte ...

    • Inflammatory genes in nasal polyposis 

      Figueiredo, Claudia Regina [UNIFESP]; Cotrim Guerreiro Silva, Ismael Dale [UNIFESP]; Weckx, Luc Louis Maurice [UNIFESP] (Lippincott Williams & Wilkins, 2008-02-01)
      Purpose of reviewThis paper is a review of the most recent literature concerning the role of inflammatory genes in nasal polyposis. the data provide evidence of a pivotal role for some inflammatory mediators in the development ...

    • Mechanical dysfunction in the mucosal oedema formation of patients with nasal polyps 

      Pezato, Rogerio [UNIFESP]; Voegels, Richard Louis; Pinto Bezerra, Thiago Freire; Perez-Novo, Claudina; Stamm, Aldo Cassol [UNIFESP]; Gregório, Luiz Carlos [UNIFESP] (Int Rhinologic Soc, 2014-06-01)
      Background: Nasal polyposis (NP) is characterized by an anomalous tissue growth with oedema and a lack of extracellular matrix. in this study, we investigated whether a mechanical disfunction of the forces that act in ...

    • Microarray cDNA to identify inflammatory genes in nasal polyposis 

      Figueiredo, Claudia R.; Santos, Rodrigo P.; Silva, Ismael D. C. G.; Weckx, Luc L. M. (Ocean Side Publications Inc, 2007-03-01)
      Background: the objective of this study was to investigate the spectrum of inflammatory gene expression in patients with nasal polyposis.Methods: the cDNA microarray technique was used to identify gene expression in tissue ...

    • Nasal Polyp-Derived Mesenchymal Stromal Cells Exhibit Lack of Immune-Associated Molecules and High Levels of Stem/Progenitor Cells Markers 

      Barbosa de Oliveira, Pedro Wey [UNIFESP]; Pezato, Rogerio [UNIFESP]; Henao Agudelo, Juan Sebastian [UNIFESP]; Perez-Novo, Claudina Angela; Berghe, Wim Vanden; Camara, Niels Olsen [UNIFESP]; de Almeida, Danilo Candido; Gregorio, Luis Carlos [UNIFESP] (Frontiers Media Sa, 2017)
      Mesenchymal stromal cells (MSCs) are considered adult progenitor stem cells and have been studied in a multitude of tissues. In this context, the microenvironment of nasal polyp tissue has several inflammatory cells, but ...

    • Role of imbalance of eicosanoid pathways and staphylococcal superantigens in chronic rhinosinusitis 

      Pezato, Rogério [UNIFESP]; Swierczynska-Krepa, M.; Nizankowska-Mogilnicka, E.; Derycke, L.; Bachert, C.; Perez-Novo, C. A. (Wiley-Blackwell, 2012-11-01)
      Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. ...