Now showing items 1-8 of 8

    • Calcineurin Inhibitor Minimization in the Symphony Study: Observational Results 3 Years after Transplantation 

      Ekberg, H.; Bernasconi, C.; Tedesco-Silva Junior, Hélio [UNIFESP]; Vitko, S.; Hugo, C.; Demirbas, A.; Reyes Acevedo, R.; Grinyo, J.; Frei, U.; Vanrenterghem, Y.; Daloze, P.; Halloran, P. F. (Wiley-Blackwell, 2009-08-01)
      The Symphony study showed that at 1 year posttransplant, a regimen based on daclizumab induction, 2 g mycophenolate mofetil (MMF), low-dose tacrolimus and steroids resulted in better renal function and lower acute rejection ...

    • FTY720 versus mycophenolate mofetil in de novo renal transplantation: Six-month results of a double-blind study 

      Tedesco-Silva, Helio; Szakaly, Peter; Shoker, Ahmed; Sommerer, Claudia; Yoshimura, Norio; Schena, Francesco Paolo; Cremer, Malika; Hmissi, Abdel; Mayer, Hartmut; Lang, Philippe; FTY720 2218 Clinical Study Grp (Lippincott Williams & Wilkins, 2007-10-15)
      Background. FTY720 is a novel immunomodulator that was developed to produce optimal graft protection with improved safety and tolerability. Phase II studies have demonstrated the efficacy of FTY720 up to the doses of 2.5 ...

    • How Delayed Graft Function Impacts Exposure to Mycophenolic Acid in Patients After Renal Transplantation 

      van Gelder, Teun; Silva, Helio Tedesco [UNIFESP]; Fijter, Hans de; Budde, Klemens; Kuypers, Dirk; Mamelok, Richard D.; Armstrong, Victor W.; Oellerich, Michael (Lippincott Williams & Wilkins, 2011-04-01)
      Introduction: Mycophenolic acid (MPA) plasma concentrations are highly variable on standard-dose mycophenolate mofetil therapy. At creatinine clearances below 25 mL/min, MPA clearance increases as a result of a higher ...

    • Mycophenolate mofetil substitution for cyclosporine A in renal transplant recipients with chronic progressive allograft dysfunction: the creeping creatinine study 

      Dudley, C.; Pohanka, E.; Riad, H.; Dedochova, J.; Wijngaard, P.; Sutter, C.; Silva, H. T.; Mycophenolate Mofetil Creep (Lippincott Williams & Wilkins, 2005-02-27)
      Background. This study determined whether cyclosporine A (CsA)-treated renal allograft recipients with deteriorating renal function (creeping creatinine) secondary to chronic allograft nephropathy (CAN) benefit from the ...

    • Mycophenolate mofetil vs. sirolimus in kidney transplant recipients receiving tacrolimus-based immunosuppressive regimen 

      Sampaio, Edison L. [UNIFESP]; Pinheiro-Machado, Paula G. [UNIFESP]; Garcia, Riberto [UNIFESP]; Felipe, Claudia R. [UNIFESP]; Park, Sung I. [UNIFESP]; Casarini, Dulce E. [UNIFESP]; Moreira, Silvia [UNIFESP]; Franco, Marcello F. [UNIFESP]; Tedesco-Silva, Helio [UNIFESP]; Medina-Pestana, Jose O. [UNIFESP] (Blackwell Publishing, 2008-03-01)
      Mycophenolate mofetil (MMF) and sirolimus (SRL) are effective immunosuppressive drugs with distinct safety profile.Methods: Kidney transplant recipients receiving tacrolimus (TAC)-based immunosuppressive regimen were ...

    • Randomized controlled trial of FTY720 versus MMF in de novo renal transplantation 

      Tedesco-Silva, Helio; Pescovitz, Mark D.; Cibrik, Diane; Rees, Michael A.; Mulgaonkar, Shamkant; Kahan, Barry D.; Gugliuzza, Kristene K.; Rajagopalan, P. R.; Esmeraldo, Ronaldo de M.; Lord, Helene; Salvadori, Maurizio; Slade, Jennifer M.; FTY720 Study Grp (Lippincott Williams & Wilkins, 2006-12-27)
      Background. Phase 11 trials of FTY720, a novel immunomodulator, have shown promise in preventing rejection with both standard and reduced cyclosporine exposure. This study was designed to confirm those findings.Methods. ...

    • Randomized crossover study to assess the inter- and intrasubject variability of morning mycophenolic acid concentrations from enteric-coated mycophenolate sodium and mycophenolate mofetil in stable renal transplant recipients 

      Tedesco-Silva, Helio [UNIFESP]; Felipe, Claudia R. [UNIFESP]; Park, Sung I. [UNIFESP]; Pinheiro-Machado, Paula G. [UNIFESP]; Garcia, Riberto [UNIFESP]; Slade, Alan; Schmouder, Robert; Medina-Pestana, Jose O. [UNIFESP] (Wiley-Blackwell, 2010-07-01)
      The delayed release of mycophenolic acid (MPA) from enteric-coated mycophenolate sodium (EC-MPS, myfortic (R)) may have an impact on the variability of MPA trough (C(0 h)) levels. A randomized, two-period crossover study ...

    • Tacrolimus pharmacokinetic drug interactions: effect of prednisone, mycophenolic acid or sirolimus 

      Park, Sung-In [UNIFESP]; Felipe, Claudia R. [UNIFESP]; Pinheiro-Machado, Paula G. [UNIFESP]; Garcia, Riberto [UNIFESP]; Fernandes, Fernanda B. [UNIFESP]; Casarini, Dulce E. [UNIFESP]; Tedesco-Silva, Helio [UNIFESP]; Medina-Pestana, Jose O. [UNIFESP] (Wiley-Blackwell, 2009-02-01)
      This study was conducted to evaluate time-dependent pharmacokinetic changes and drug interactions over the first 6 months after transplantation in kidney transplant recipients receiving tacrolimus (TAC), prednisone (PRED) ...