Browsing by Subject "multiple myeloma"

Now showing items 1-10 of 11

    • Advances in the treatment of multiple myeloma: the role of thalidomide 

      Ribas, Christian [UNIFESP]; Colleoni, Gisele Wally Braga [UNIFESP] (Taylor & Francis Ltd, 2003-01-01)
      Multiple myeloma (MM) accounts for 1% of all malignancies and 10% of malignant hematological neoplasms. in spite of high-dose therapy with stem cell rescue, relapse and disease resistance are common events in the course ...

    • Bilateral central retinal vein occlusion associated with multiple myeloma 

      Aggio, F. B.; Cariello, A. J.; Almeida, MSS; Rodrigues, C. A.; Moraes, NSB de; Colleoni, GWB; Farah, M. E. (Karger, 2004-01-01)
      Purpose: To report a case of simultaneous bilateral central retinal vein occlusion (CRVO) associated with multiple myeloma. Methods: A 65-year-old woman had sudden, painless loss of vision in both eyes for 20 days. ...

    • Diagnosis of chronic lymphoproliferative disorders by flow cytometry using four-color combinations for immunophenotyping: A proposal of the brazilian group of flow cytometry (GBCFLUX) 

      Sales, M. M.; Ferreira, S. I. A. C. P.; Ikoma, M. R. V.; Sandes, A. F.; Beltrame, M. P.; Bacal, N. S.; Silva, M. C. A.; Malvezzi, M.; Lorand-Metze, I. G. H.; Orfao, A.; Yamamoto, M. [UNIFESP] (Wiley, 2017)
      BackgroundMultiparametric flow cytometry (MFC) is a powerful tool for the diagnosis of hematological malignancies and has been useful for the classification of chronic lymphoproliferative disorders (CLPD) according to the ...

    • Endocarditis due to glycopeptide-intermediate Staphylococcus aureus: case report and strain characterization 

      Andrade-Baiocchi, S.; Tognim, MCB; Baiocchi, Otavio Carvalho Guimarães [UNIFESP]; Sader, H. S. (Elsevier B.V., 2003-02-01)
      We report a case of infective endocarditis due to vancomycin-intermediate Staphylococcus aureus (VISA) that did not respond to high doses of vancomycin. Initial vancomycin MIC of the last isolate recovered from blood was ...

    • Estudos funcionais da expressão dos genes triap1 e hsp70 em linhagens celulares de mieloma múltiplo 

      Alves, Veruska Lia Fook [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2014-08-28)
      Introduction: Some evidences suggest that heat shock protein 70 (HSP70) is overexpressed in many types of cancer, and that high expression of this chaperone is linked with increasing tumor grade and/or poor prognosis. The ...

    • Is there any relationship between gene expression of tumor antigens and CD4(+) T cells in multiple myeloma? 

      Braga, Walter M. T.; Silva, Bruna R. da [UNIFESP]; Alves, Veruska L. F. [UNIFESP]; Bortoluzo, Adriana B.; Atanackovic, Djordje; Colleoni, Gisele W. B. [UNIFESP] (Future Medicine Ltd, 2014-05-01)
      Aim: the present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells. Materials & methods: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 ...

    • N-RAS and K-RAS gene mutations in Brazilian patients with multiple myeloma 

      Ortega, Manoela M.; Faria, Rosa MD [UNIFESP]; Shitara, Edson S.; Assis, Angela M.; Albuquerque, Dulcinéia M.; Oliveira, José SR; Noguti, Maria Aparecida Eiko [UNIFESP]; Faria, Jose Roberto de [UNIFESP]; Costa, Fernando Ferreira [UNIFESP]; Lima, Carmen Silvia Passos (Taylor & Francis Ltd, 2006-02-01)
      Point mutations affecting codons 12, 13 (exon 1) and 61 (exon 2) of the N-RAS gene and codons 12 and 13 (exon 1) of the K-RAS gene are identified in approximately 30.0% and 10.0%, respectively, of multiple myeloma (MM) ...

    • p16 gene methylation lacks correlation with angiogenesis and prognosis in multiple myeloma 

      Ribas, C.; Colleoni, GWB; Felix, R. S.; Silva, MRR; Caballero, O. L.; Brait, M.; Bordin, J. O. (Elsevier B.V., 2005-05-26)
      Methylation of p16 gene is a relatively frequent molecular finding in multiple myeloma (MM), but its clinical implication is disputable. Cell cycle regulators are now recognized as active in the control of angiogenesis, ...

    • Prognostic significance of vascular endothelial growth factor immunoexpression in the context of adverse standard prognostic factors in multiple myeloma 

      Ribas, C.; Colleoni, GWB; Silva, MRR; Carregoza, M. J.; Bordin, J. O. (Blackwell Munksgaard, 2004-11-01)
      Objectives: Vascular endothelial growth factor (VEGF) acts in several steps of multiple myeloma (MM) pathogenesis and it is an important mediator of tumor angiogenesis. the aim of this study was to examine the prognostic ...

    • Proteasome and heat shock protein 70 (HSP70) inhibitors as therapeutic alternative in multiple myeloma 

      Pereira Eugenio, Angela Isabel [UNIFESP]; Fook-Alves, Veruska Lia [UNIFESP]; de Oliveira, Mariana Bleker [UNIFESP]; Fernando, Rodrigo Carlini [UNIFESP]; Zanatta, Daniela B.; Strauss, Bryan Eric; Regis Silva, Maria Regina [UNIFESP]; Porcionatto, Marimelia Aparecida [UNIFESP]; Braga Colleoni, Gisele Wally [UNIFESP] (Impact Journals Llc, 2017)
      HSP70 connects multiple signaling pathways that work synergistically to protect tumor cells from death by proteotoxic stress and represents a possible target to establish a new approach for multiple myeloma treatment. ...