Browsing by Subject "mitochondria"
Now showing items 1-10 of 40
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Age-related mitochondrial DNA point mutations in patients with mitochondrial myopathy
(Elsevier B.V., 2007-12-15)Mutations in the control region (D-loop) of mitochondrial DNA (mtDNA) have been described in normal old individuals and it is suggested that they originated from oxidative damage. Respiratory chain defects may lead to ...
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Analysis of the functional aspects and seminal plasma proteomic profile of sperm from smokers
(Wiley, 2016)Objective To evaluate the effect of smoking on sperm functional quality and seminal plasma proteomic profile. Patients and Methods Sperm functional tests were performed in 20 non-smoking men with normal semen quality, ...
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Análise proteômica quantitativa de plasma seminal e sua associação com aspectos funcionais dos espermatozoides e com o nível de peroxidação lipídica no plasma seminal
(Universidade Federal de São Paulo (UNIFESP), 2014)funcionais nos espermatozoides e o nivel seminal de peroxidacao lipidica. Metodo: Um estudo transversal foi realizado incluindo 156 pacientes normozoospermicos. Apos a coleta do semen por masturbacao, uma aliquota foi ...
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Apoptotic effect of ethanol is potentiated by caffeine-induced calcium release in rat astrocytes
(Elsevier B.V., 2006-01-30)In this study, we investigated agents that increased intracellular calcium levels and their correlation with apoptotic cell death induction. We used rat astrocytes to investigate the increase in cytosolic Ca2+, (Ca-c(2+)) ...
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Association between the seminal plasma proteome and sperm functional traits
(Elsevier Science Inc, 2016)Objective: To analyze the seminal plasma proteome and biological functions associated with sperm functional alterations. Design: Cross-sectional study. Setting: University andrology and research laboratories. Patient(s): ...
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Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model
(Mdpi, 2018)Astaxanthin (ASTA) is a ketocarotenoid found in many marine organisms and that affords many benefits to human health. ASTA is particularly effective against radical-mediated lipid peroxidation, and recent findings hypothesize ...
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Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation
(Nature Publishing Group, 2004-12-01)In the present study, we evaluated proapoptotic protein Bax on mitochondria and Ca2+ homeostasis in primary cultured astrocytes. We found that recombinant Bax (rBax, 10 and 100 ng/ml) induces a loss in mitochondrial membrane ...
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Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential
(Nature Publishing Group, 2001-09-01)Bax, a pro-apoptotic member of the Bcl-2 family, is a cytosolic protein that inserts into mitochondrial membranes upon induction of cell death. Using the green fluorescent protein fused to Bax (GFP-Bax) to quantitate ...
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Bcl-X-L inhibits Bax-induced alterations in mitochondrial respiration and calcium release
(Elsevier B.V., 2008-09-12)Apoptosis is a natural cell elimination process involved in a number of physiological and pathological events. This process can be regulated by members of the Bcl-2 family. Bax, a pro-apoptotic member of this family, ...
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Calcium and cell death signaling in neurodegeneration and aging
(Academia Brasileira de Ciências, 2009-09-01)Transient increase in cytosolic (Cac2+) and mitochondrial Ca2+ (Ca m2+) are essential elements in the control of many physiological processes. However, sustained increases in Ca c2+ and Ca m2+ may contribute to oxidative ...