Now showing items 1-10 of 33

    • Acute effects of low doses of melatonin on the sleep of young healthy subjects 

      Pires, MLN; Benedito-Silva, A. A.; Pinto, L.; Souza, L.; Vismari, L.; Calil, H. M. (Munksgaard Int Publ Ltd, 2001-11-01)
      This study was undertaken to evaluate the acute effects of single low doses of melatonin given to healthy volunteers in the evening, Six healthy male volunteers (age range 22-24 years) participated in this study, after ...

    • Análise do polimorfismo do gene do receptor de melatonina mtnr1b em mulheres com síndrome dos ovários policisticos em uso de metformina e antinconcepcional 

      Iwata, Margareth Chiharu [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2014-02-12)
      INTRODUCTION.The polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive age in women. The exact pathophysiological mechanism of the syndrome remains unclear, but it is believed that insulin ...

    • Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions 

      Fighera, M. R.; Queiroz, C. M.; Stracke, M. P.; Brauer, MCN; Gonzalez-Rodriguez, L. L.; Frussa, R.; Wajner, M.; Mello, C. F. de (Lippincott Williams & Wilkins, 1999-07-13)
      THE effects of chronic administration of alpha-tocopherol or melatonin, or acute ascorbic acid administration on the convulsant action of methylmalonic acid (MMA) were investigated in adult male rats. Animals were chronically ...

    • Corticosterone modulates noradrenaline-induced melatonin synthesis through inhibition of nuclear factor kappa B 

      Ferreira, Z. S.; Fernandes, PACM; Duma, D.; Assreuy, J.; Avellar, MCW; Markus, R. P. (Blackwell Munksgaard, 2005-04-01)
      In chronically inflamed animals, adrenal hormones exert a positive control on the secretion of melatonin by the pineal gland. in this paper, the mechanism of corticosterone as a modulator of melatonin and N-acetylserotonin ...

    • Different criteria of sleep latency and the effect of melatonin on sleep consolidation 

      Pinto Júnior, Luciano Ribeiro [UNIFESP]; Seabra, Maria de Lourdes [UNIFESP]; Tufik, Sergio [UNIFESP] (Amer Academy Sleep Medicine, 2004-09-15)
      Objectives: Since there is no consensus definition of sleep onset, we studied different aspects of initial sleep periods in healthy volunteers taking melatonin. Two criteria for sleep latency were used: 10 minutes of ...

    • Distribuição e expressão dos receptores de melatonina no hipocampo de ratos submetidos ao modelo de epilepsia induzida por pilocarpina 

      Rocha, Anna Karynna Alves de Alencar [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2014-10-31)
      Studies from our laboratory have shown a neuroprotective effect of melatonin on pilocarpine-induced epilepsy. The pinealectomy is able to facilitate the epileptogenesis while the melatonin exerted a neuroprotection in the ...

    • Efeito neuroprotetor da melatonina e N-acetilserotonina na epileptogênese e no controle de crises em animais submetidos ao modelo da pilocarpina 

      Lima, Eliângela de [UNIFESP]; Cabral, Francisco Romero [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Naffah-Mazzacoratti, Maria da Graca [UNIFESP]; Amado, Débora [UNIFESP] (Liga Brasileira de Epilepsia (LBE), 2006-06-01)
      PURPOSE: The aim of this research was to study the effects of treatment with melatonin and N-acetilserotonin in the development of pilocarpina model of epilepsy in adult male rats. METHODS: Part I - The animals were divided ...

    • Efeitos da melatonina no sistema genital feminino: breve revisão 

      Maganhin, Carla Cristina [UNIFESP]; Carbonel, Adriana Aparecida Ferraz [UNIFESP]; Hatty, Juliana Halley [UNIFESP]; Fuchs, Luiz Fernando Portugal [UNIFESP]; De Oliveira-Junior, Itamar Souza [UNIFESP]; Simoes, Manuel de Jesus [UNIFESP]; Simoes, Ricardo S. [UNIFESP]; Baracat, Edmund Chada [UNIFESP]; Soares-Jr, Jose Maria [UNIFESP] (Assoc Medica Brasileira, 2008-05-01)
      Melatonin is secreted by the pineal gland and this is linked to the day/night cycle. It is an antioxidant and plays a fundamental role in the regulation of the jet-lag stage, in several physiological reactions and in control ...

    • Efeitos da melatonina, metformina e citrato de clomifeno em ovários de ratas em estro permanente 

      Lombardi, Leonardo Augusto [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2016-12-21)
      Analysing histomorphometric and immunohistochemical changes in the interstitial cells and ovarian follicles of rats treated with melatonin, metformin and clomiphene citrate before and after induction of permanent estrus. ...

    • Effect of aerobic physical exercise in pinealectomized animals submitted to the pilocarpine model of epilepsy 

      Siliano, Marcelo Reina [UNIFESP]; Lima, Eliângela de [UNIFESP]; Valente, Sandra Gomes [UNIFESP]; Naffah-Mazzacoratti, Maria da Graca [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Amado, Débora [UNIFESP] (Liga Brasileira de Epilepsia (LBE), 2006-06-01)
      OBJECTIVE: To better clarify the positive effects of physical exercise in the epilepsy, we analyzed the effect of the pinealectomy in animals with temporal lobe epilepsy (TLE) induced by pilocarpine submitted to an aerobic ...