Now showing items 1-10 of 21

    • Adiposity in childhood cancer survivors: insights into obesity physiopathology 

      Siviero-Miachon, Adriana Aparecida [UNIFESP]; Spinola-Castro, Angela Maria [UNIFESP]; Guerra-Junior, Gil (Sociedade Brasileira de Endocrinologia e Metabologia, 2009-03-01)
      As childhood cancer treatment has become more effective, survival rates have improved, and a number of complications have been described while many of these patients reach adulthood. Obesity is a well-recognized late effect, ...

    • Assessment of aerobic capacity during swimming exercise in ob/ob mice 

      Almeida, W. S.; Lima, L. C. J.; Cunha, V. N. C.; Cunha, R. R.; Araujo, R. C.; Barros, C. C. [UNIFESP]; Simoes, H. G.; Campbell, C. S. G. (Wiley-Blackwell, 2011-12-01)
      Obesity is a highly prevalent condition associated with several diseases. Physical exercise has been considered as a non-pharmacological tool in the treatment of obesity. However, several aspects underlying exercise ...

    • Bradykinin inhibits hepatic gluconeogenesis in obese mice 

      Barros, Carlos Castilho [UNIFESP]; Haro, Anderson [UNIFESP]; Russo, Fernanda Jaqueline [UNIFESP]; Schadock, Ines; Almeida, Sandro Soares [UNIFESP]; Reis, Felipe Castellani [UNIFESP]; Moraes, Milton Rocha [UNIFESP]; Haidar, Andre [UNIFESP]; Hirata, Aparecida Emiko [UNIFESP]; Mori, Marcelo [UNIFESP]; Pereira Bacurau, Reury Frank; Wurtele, Martin [UNIFESP]; Bader, Michael; Pesquero, Joao Bosco [UNIFESP]; Araujo, Ronaldo Carvalho [UNIFESP] (Nature Publishing Group, 2012-10-01)
      The kallikrein-kinin system (KKS) has been previously linked to glucose homeostasis. in isolated muscle or fat cells, acute bradykinin (BK) stimulation was shown to improve insulin action and increase glucose uptake by ...

    • Efeitos do exercício crônico sobre a concentração circulante da leptina e grelina em ratos com obesidade induzida por dieta 

      Eguchi, Ricardo [UNIFESP]; Cheik, Nadia Carla; Oyama, Lila Missae [UNIFESP]; Nascimento, Claudia Maria da Penha Oller do [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Tufik, Sergio [UNIFESP]; Dâmaso, Ana Raimunda [UNIFESP] (Sociedade Brasileira de Medicina do Exercício e do Esporte, 2008-06-01)
      Obesity is becoming one of the biggest worldwide epidemics. Therefore, knowing its etiology and mechanisms that regulate its development is of great relevance for its treatment. Thus, the aim of the present study was to ...

    • Effect of angiotensin converting enzyme inhibitor enalapril on body weight and composition in young rats 

      Santos, Edson L. [UNIFESP]; Souza, Kely de Picoli [UNIFESP]; Guimarães, Paola Bianchi [UNIFESP]; Reis, Felipe Castellani Gomes [UNIFESP]; Silva, Sylvia Maria Affonso [UNIFESP]; Costa-Neto, Claudio M.; Luz, Jacqueline [UNIFESP]; Pesquero, João Bosco [UNIFESP] (Elsevier B.V., 2008-02-01)
      Obesity is considered a worldwide public health problem showing an increased prevalence in developing countries, with urgent need for new and more efficient drugs and therapies. Enalapril, an angiotensin-I converting enzyme ...

    • Efficient method for obtaining Lep(ob)/Lep(ob)-derived animal models using adipose tissue transplantations 

      Barros, C. C. [UNIFESP]; Almeida, S. S. [UNIFESP]; Mori, M. A. [UNIFESP]; Valero, V. B. [UNIFESP]; Haro, A. S. [UNIFESP]; Batista, E. C. [UNIFESP]; Rosa, T. S.; Bacurau, Reury Frank Pereira; Wuertele, M. [UNIFESP]; Araujo, R. C. [UNIFESP] (Nature Publishing Group, 2009-08-01)
      Background: Leptin-deficient mice (Lep(ob)/Lep(ob), also known as ob/ob) are of great importance for studies of obesity, diabetes and other correlated pathologies. Thus, generation of animals carrying the Lep(ob) gene ...

    • In vitro evaluation of leptin fragments activity on the ob receptor 

      Oliveira, Vani Xavier de; Fazio, Marcos Antonio [UNIFESP]; Santos, Edson Lucas [UNIFESP]; Pesquero, Joao Bosco [UNIFESP]; Miranda, Antonio [UNIFESP] (Wiley-Blackwell, 2008-05-01)
      In an attempt to identify regions in the leptin molecule responsible for its bioactivity, we tested six related-leptin peptide fragments denoted: Ae-hLEP(23-47)-NH(2) (I), Ac-hLEP(48-71)-NH(2) (II), Ac-hLEP(72-88)-NH(2) ...

    • Influence of dexamethasone and weight loss on the regulation of serum leptin levels in obese individuals 

      Lerario, D.d.g. [UNIFESP]; Ferreira, Sandra Roberta Gouvea [UNIFESP]; Miranda, Walkiria Lopes [UNIFESP]; Chacra, Antonio Roberto [UNIFESP] (Associação Brasileira de Divulgação Científica, 2001-04-01)
      The adipocyte hormone leptin is thought to serve as a signal to the central nervous system reflecting the status of fat stores. Serum leptin levels and adipocyte leptin messenger RNA levels are clearly increased in obesity. ...

    • Kinin B-1 receptor stimulation modulates leptin homeostasis. Evidence for an insulin-dependent mechanism 

      Mori, Marcelo A. [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Pesquero, Joao B. [UNIFESP] (Elsevier B.V., 2008-02-01)
      Kinins are potent vasoactive and inflammatory peptides generated by kallikreins in blood and tissues that bind to specific receptors named B-1 and B-2. On the other hand, leptin is an adipocytokine that displays broad ...

    • Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant? 

      Moraes-Vieira, P. M. M.; Bassi, E. J.; Araujo, R. C. [UNIFESP]; Camara, N. O. S. (Wiley-Blackwell, 2012-08-01)
      Food intake and nutritional status modify the physiological responses of the immune system to illness and infection and regulate the development of chronic inflammatory processes, such as kidney disease. Adipose tissue ...