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    • Increase of SARS-CoV 3CL peptidase activity due to macromolecular crowding effects in the milieu composition 

      Okamoto, Debora N. [UNIFESP]; Oliveira, Lilian C. G. [UNIFESP]; Kondo, Marcia Y. [UNIFESP]; Cezari, Maria H. S. [UNIFESP]; Szeltner, Zoltan; Juhasz, Nde; Juliano, Maria A. [UNIFESP]; Polgar, Laszlo; Juliano, Luiz [UNIFESP]; Gouvea, Iuri E. [UNIFESP] (Walter de Gruyter & Co, 2010-12-01)
      The 3C-like peptidase of the severe acute respiratory syndrome virus (SARS-CoV) is strictly required for viral replication, thus being a potential target for the development of antiviral agents. in contrast to monomeric ...