Now showing items 1-8 of 8

    • Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice 

      Becari, Christiane; Durand, Marina T.; Guimaraes, Alessander O. [UNIFESP]; Lataro, Renata M.; Prado, Cibele M.; de Oliveira, Mauro; Candido, Sarai C. O.; Pais, Paloma; Ribeiro, Mauricio S.; Bader, Michael; Pesquero, Joao B. [UNIFESP]; Salgado, Maria C. O.; Salgado, Helio C. (Frontiers Media Sa, 2017)
      In vitro and ex vivo experiments indicate that elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, is an alternative pathway for angiotensin II (Ang II) generation. However, the role played by ...

    • Evidence for the participation of kinins in Freund's adjuvant-induced inflammatory and nociceptive responses in kinin B-1 and B-2 receptor knockout mice 

      Ferreira, J.; Campos, M. M.; Pesquero, J. B.; Araujo, R. C.; Bader, M.; Calixto, J. B. (Elsevier B.V., 2001-12-01)
      Experiments were designed to investigate the rule of kinin B-1 and B-2 receptors in Freund's adjuvant (CFA)-induced inflammation and nociception responses by the use of B-1 and B-2 null mutant mice. Intradermal (i.d.) ...

    • Genetic deletion or antagonism of kinin B-1 and B-2 receptors improves cognitive deficits in mouse a model of Alzheimer's disease 

      Prediger, R. D. S.; Medeiros, R.; Pandolfo, P.; Duarte, F. S.; Passos, G. F.; Pesquero, J. B. [UNIFESP]; Campos, M. M.; Calixto, J. B.; Takahashi, R. N. (Elsevier B.V., 2008-02-06)
      Increased brain deposition of amyloid beta protein (A beta) and cognitive deficits are classical signs of Alzheimer's disease (AD) that have been widely associated to inflammatory response. We have recently shown that a ...

    • Genetically altered animals in the study of the metabolic functions of peptide hormone systems 

      Mori, Marcelo Alves da Silva [UNIFESP]; Bader, Michael [UNIFESP]; Pesquero, João Bosco [UNIFESP] (Lippincott Williams & Wilkins, 2008-01-01)
      Purpose of reviewHere we review the use of genetically altered animals to address the roles of peptide hormone systems in the modulation of energy homeostasis. Despite the disseminated use of transgenic techniques to ...

    • Kinin B1 receptor gene ablation affects hypothalamic CART production 

      Torres, Hugo A. M. [UNIFESP]; Motta, Fabiana Louise [UNIFESP]; Sales, Vicencia Micheline [UNIFESP]; Batista, Carolina [UNIFESP]; Silva, Joelcimar M. da; Vignoli, Thiago [UNIFESP]; Barnabe, Gabriela F. [UNIFESP]; Goeldner, Francine O. [UNIFESP]; D'Almeida, Vania [UNIFESP]; Bittencourt, Jackson C.; Sinigaglia-Coimbra, Rita [UNIFESP]; Bader, Michael; Mello, Luiz Eugenio A. M. [UNIFESP]; Pesquero, Joao Bosco [UNIFESP] (Walter de Gruyter Gmbh, 2013-07-01)
      A role for the kinin B1 receptor in energy-homeostatic processes was implicated in previous studies; notably, the studies where kinin B1 receptor knockout mice (B1(-/-)) were shown to have impaired adiposity, impaired ...

    • Kinin B1 receptors facilitate the development of temporal lobe epilepsy in mice 

      Silva, J. A.; Goto, E. M. [UNIFESP]; Perosa, S. R. [UNIFESP]; Arganaraz, G. A. [UNIFESP]; Cavalheiro, E. A. [UNIFESP]; Naffah-Mazzacoratti, M. G. [UNIFESP]; Pesquero, J. B. [UNIFESP] (Elsevier B.V., 2008-02-01)
      Kinins may play a relevant role in epilepsy. in the present study, we evaluated the hippocampal expression of the remaining kinin receptor in 131 (B1KO) and B2 (B2KO) knockout mice strains during the development of pilocarpine ...

    • Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes 

      Bachvarov, D.; Bachvarova, M.; Koumangaye, R.; Klein, J.; Pesquero, J. B.; Neau, E.; Bader, M.; Schanstra, J. P.; Bascands, J. L. (Walter de Gruyter & Co, 2006-01-01)
      The kinin B2 receptor, which is constitutively expressed in a large number of tissues, mediates most of the known effects of bradykinin (BK). Normally undetectable in healthy tissues, the B1 receptor is strongly over-expressed ...

    • The use of kinin B-1 and B-2 receptor knockout mice and selective antagonists to characterize the nociceptive responses caused by kinins at the spinal level 

      Ferreira, J.; Campos, M. M.; Araujo, R.; Bader, M.; Pesquero, J. B.; Calixto, J. B. (Elsevier B.V., 2002-12-01)
      The mechanisms by which kinins induce hyperalgesia in the spinal cord were investigated by using B-1 or B-2 knockout mice in conjunction with kinin selective agonists and antagonists. the i.t. administration of the kinin ...