Browsing by Subject "kinins"

Now showing items 1-10 of 15

    • Absence of diabetic hyperalgesia in bradykinin B-1 receptor-knockout mice 

      Gabra, B. H.; Merino, V. F.; Bader, M.; Pesquero, J. B.; Sirois, P. (Elsevier B.V., 2005-04-15)
      Experimental evidence has shown that the inducible bradykinin (BK) B-1 receptor (BKB1-R) subtype is involved in the development of hyperalgesia associated with type 1 diabetes. Selective BKB1-R antagonists inhibited, whereas ...

    • Altered renal response to acute volume expansion in transgenic rats harboring the human tissue kallikrein gene 

      Passaglio, K. T.; Baltatu, O.; Machado, R. P.; Reis, A. M. dos; Pesquero, J. B.; Bader, M.; Santos, RAS (Elsevier B.V., 2005-01-15)
      The renal response to acute volume expansion was investigated in transgenic (TGR) rats harboring the human tissue kallikrein gene. After a printer injection of 0.9% NaCl (3 ml/100 g, i.v), Sprague-Dawley (SD) or TGR rats ...

    • Angiotensin I-converting enzyme activity in tubular fluid along the rat nephron 

      Casarini, Dulce Elena [UNIFESP]; Boim, Mirian Aparecida [UNIFESP]; Stella, Regina Celes de Rosa [UNIFESP]; Krieger-Azzolini, M. H. [UNIFESP]; Krieger, Jose Eduardo [UNIFESP]; Schor, Nestor [UNIFESP] (Amer Physiological Soc, 1997-03-01)
      The activity of angiotensin I-converting enzyme (ACE) was determined in tubular fluid collected from several portions of the rat nephron and urine and in total and efferent arteriolar blood using hippuryl-L-His-leu as ...

    • Evidence for activation of the tissue kallikrein-kinin system in nociceptive transmission and inflammatory responses of mice using a specific enzyme inhibitor 

      Emim, José AD; Souccar, Caden [UNIFESP]; Castro, Maria SD; Godinho, Rosely Oliveira [UNIFESP]; Cezari, Maria HS; Juliano, Luiz [UNIFESP]; Lapa, Antonio José [UNIFESP] (Nature Publishing Group, 2000-07-01)
      1 the pharmacological activity of phenylacetyl-Phe-Ser-Arg-N-(2,4-dinitrophenyl)-ethylenediamine (TKI), a tissue kallikrein specific inhibitor, was assessed using models of nociception and inflammation in mice.2 Injection ...

    • High expression of human carboxypeptidase M in Pichia pastoris. Purification and partial characterization 

      Craveiro, Rogerio Bastos [UNIFESP]; Ramalho, João Daivison Silva [UNIFESP]; Chagas, Jair Ribeiro [UNIFESP]; Wang, Pamella Huey Mei [UNIFESP]; Casarini, Dulce Elena [UNIFESP]; Pesquero, Jorge Luiz [UNIFESP]; Araujo, Ronaldo Carvalho [UNIFESP]; Pesquero, João Bosco [UNIFESP] (Assoc Bras Divulg Cientifica, 2006-02-01)
      Carboxypeptidase M (CPM) is an extracellular glycosylphosphatidylinositol-anchored membrane glycoprotein, which removes the C-terminal basic residues, lysine and arginine, from peptides and proteins at neutral pH. CPM plays ...

    • Increase in kinins on post-exercise hypotension in normotensive and hypertensive volunteers 

      Moraes, Milton R.; Bacurau, Reury Frank Pereira; Ramalho, Joao D. S.; Reis, Felipe C. G.; Casarini, Dulce E.; Chagas, Jair R.; Oliveira, Vitor; Higa, Elisa Mieko S.; Abdalla, Dulcineia S. R.; Pesquero, Jorge L.; Pesquero, Joao B.; Araujo, Ronaldo C. (Walter de Gruyter & Co, 2007-05-01)
      Post-exercise hypotension is an important event for blood pressure regulation, especially in hypertensive individuals. Although post-exercise hypotension is a well-known phenomenon, the mechanism responsible is still ...

    • Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex 

      Svensjo, E.; Batista, P. R.; Brodskyn, C. I.; Silva, R.; Lima, APCA; Schmitz, V; Saraiva, E.; Pesquero, J. B.; Mori, MAS; Muller-Esterl, W.; Scharfstein, J. (Elsevier B.V., 2006-01-01)
      Kinins, the vasoactive peptides proteolytically liberated from kininogens, were recently recognized as signals alerting the innate immune system. Here we demonstrate that Leishmania donovani and Leishmania chagasi, two ...

    • Kinin B-1 receptor participates in the control of cardiac function in mice 

      Lauton-Santos, Sandra; Guatimosim, Silvia; Castro, Carlos H.; Oliveira, Fernando A.; Almeida, Alvair P.; Dias-Peixoto, Marco Fabricio; Gomes, Maria Aparecida; Pessoa, Phillipe; Pesquero, Jorge L.; Pesquero, Joao B.; Bader, Michael; Cruz, Jader S. (Elsevier B.V., 2007-08-16)
      The kinins have an important role in control of the cardiovascular system. They have been associated with protective effects in the heart tissue. Kinins act through stimulation of two 7-transmembrane G protein-coupled ...

    • Kinin B1 receptors facilitate the development of temporal lobe epilepsy in mice 

      Silva, J. A.; Goto, E. M. [UNIFESP]; Perosa, S. R. [UNIFESP]; Arganaraz, G. A. [UNIFESP]; Cavalheiro, E. A. [UNIFESP]; Naffah-Mazzacoratti, M. G. [UNIFESP]; Pesquero, J. B. [UNIFESP] (Elsevier B.V., 2008-02-01)
      Kinins may play a relevant role in epilepsy. in the present study, we evaluated the hippocampal expression of the remaining kinin receptor in 131 (B1KO) and B2 (B2KO) knockout mice strains during the development of pilocarpine ...

    • Molecular biology of the kallikrein-kinin system: from structure to function 

      Pesquero, João Bosco [UNIFESP]; Bader, Michael [UNIFESP] (Associação Brasileira de Divulgação Científica, 1998-09-01)
      The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and ...