Now showing items 1-9 of 9

    • Autonomic control in rats with overactivity of tissue renin-angiotensin or kallikrein-kinin system 

      Ribeiro, J. M.; Santos, RAS; Pesquero, J. B.; Bader, M.; Krieger, E. M. (Elsevier B.V., 2005-07-15)
      The renin-angiotensin system (RAS) plays an important role in the regulation of the cardiovascular system and the kallikrein-kinin system (KKS) appears to counteract most of the RAS effects. in this study the vagal and the ...

    • Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease 

      Iores-Marcal, Ligia M. [UNIFESP]; Viel, Tania A.; Buck, Hudson Sousa; Nunes, Viviane A. [UNIFESP]; Gozzo, Andrezza Justino [UNIFESP]; Cruz-Silva, Ilana [UNIFESP]; Miranda, Antonio [UNIFESP]; Shimamoto, Kazuaki; Ura, Nobuyuki; Araujo, Mariana S. [UNIFESP] (Elsevier B.V., 2006-12-01)
      The kallikrein-kinin system is involved in a variety of physiological and pathological processes. Components of this system, identified in rat and human brains, can be altered in neurodegenerative processes such as Alzheimer's ...

    • Endopeptidases (kininases) are able to hydrolyze kinins in tubular fluid along the rat nephron 

      Casarini, Dulce Elena [UNIFESP]; Boim, Mirian Aparecida [UNIFESP]; Stella, Regina Celes de Rosa [UNIFESP]; Schor, Nestor [UNIFESP] (Amer Physiological Soc, 1999-07-01)
      The activities of serine endopeptidase, prolyl endopeptidase and neutral endopeptidase were determined in tubular fluid collected from several portions of the rat nephron as well as in urine. The enzyme activities were ...

    • Genetically altered animals in the study of the metabolic functions of peptide hormone systems 

      Mori, Marcelo Alves da Silva [UNIFESP]; Bader, Michael [UNIFESP]; Pesquero, João Bosco [UNIFESP] (Lippincott Williams & Wilkins, 2008-01-01)
      Purpose of reviewHere we review the use of genetically altered animals to address the roles of peptide hormone systems in the modulation of energy homeostasis. Despite the disseminated use of transgenic techniques to ...

    • Kinin-B2 receptor expression and activity during differentiation of embryonic rat neurospheres 

      Martins, Antonio Henrique Baccin [UNIFESP]; Alves, Janaina Maria [UNIFESP]; Trujillo, Cleber A.; Schwindt, Telma Tiemi [UNIFESP]; Barnabe, Gabriela Filooso [UNIFESP]; Motta, Fabiana Louise Teixeira [UNIFESP]; Guimarães, Alessander de Oliveira [UNIFESP]; Casarini, Dulce Elena [UNIFESP]; Mello, Luiz Eugenio Araujo de Moraes [UNIFESP]; Pesquero, Joao Bosco [UNIFESP]; Ulrich, Henning (Wiley-Blackwell, 2008-04-01)
      Neural progenitor cells were isolated from rat fetal telencephalon and proliferate as neurospheres in the presence of EGF, FGF-2, and heparin. in the absence of these growth factors, neurospheres differentiate into neurons, ...

    • Kinins and microglial responses in bipolar disorder: a neuroinflammation hypothesis 

      Naaldijk, Yahaira M.; Bittencourt, Maria C. [UNIFESP]; Sack, Ulrich; Ulrich, Henning (Walter De Gruyter Gmbh, 2016)
      Bipolar disorder (BD) is a severe psychiatric disorder that affects up to 15% of the worldwide population. Characterized by switches in mood between mania and depression, its etiology is still unknown and efforts have been ...

    • Leptin deficiency leads to the regulation of kinin receptors expression in mice 

      Abe, Karina Camasmie; Silva Mori, Marcelo Alves da; Pesquero, Joao Bosco (Elsevier B.V., 2007-02-01)
      Kinins are vasoactive and pro-inflammatory peptides generated by the cleavage of the kininogen by kallikreins. Two kinin receptors have been described and denominated B1 and B2. Obesity frequently accompanies other ...

    • Role of the kallikrein-kinin system in Ang-(1-7)-induced vasodilation in mesenteric arterioles of Wistar rats studied in vivo-in situ 

      Marangoni, R. A.; Carmona, A. K.; Passaglia, RCAT; Nigro, D.; Fortes, Z. B.; Carvalho, MHC de (Elsevier B.V., 2006-07-01)
      Angiotensin-(1-7) [Ang-(1-7)], exerts a variety of actions in the cardiovascular system, with an important effect being vasodilation. in this work, we investigated the relationship between the vasodilatory activity of ...

    • Structure and expression of two kininogen genes in mice 

      Cardoso, C. C.; Garrett, T.; Cayla, C.; Meneton, P.; Pesquero, J. B.; Bader, M. (Walter de Gruyter & Co, 2004-03-01)
      Kininogens serve dual functions by forming a scaffold for the assembly of the protein complex initiating the surfaceactivated blood coagulation cascade and as precursors for the kinin hormones. While rats have three kininogen ...