Now showing items 1-7 of 7

    • Activation of P2Y(1) receptor triggers two calcium signaling pathways in bone marrow erythroblasts 

      Paredes-Gamero, E. J.; Craveiro, R. B.; Pesquero, J. B.; Franca, J. P.; Oshiro, MEM; Ferreira, A. T. (Elsevier B.V., 2006-03-18)
      In this study, we describe the presence of P2 receptor subtypes and Ca2+ signaling in erythroblasts. ATP and ADP produced a biphasic increase of intracellular Ca2+ concentration ([Ca2+],), with an initial transient phase ...

    • Cyclosporin A tubular effects contribute to nephrotoxicity: role for Ca2+ and Mg2+ ions 

      Costa, Maristela Carvalho da; Castro, Isac de; Cuvello Neto, Américo L; Ferreira, Alice T. [UNIFESP]; Burdmann, Emmanuel A.; Yu, Luis (Oxford Univ Press, 2003-11-01)
      Background. Cyclosporin A (CsA) nephrotoxicity has been attributed primarily to renal haemodynamic alterations caused by afferent arteriolar vasoconstriction. However, CsA nephropathy is also characterized by CsA-induced ...

    • Effect of cyclosporin A on nitric oxide production in cultured LLC-PK1 cells 

      Lima, R.; Serone, A. P.; Schor, N.; Higa, EMS (Marcel Dekker Inc, 2001-01-01)
      The effect of Cyclosporin A on nitric oxide production was studied in cultured LLC- PK1 cells. for this purpose the cells were incubated with vehicle (olive oil, 10 mug/ml in DMSO), Cyclosporin A (CsA, 10 mug/ml), tumor ...

    • Effects of arachnotoxin on intracellular pH and calcium in human spermatozoa 

      Romero, Fernando; Cunha, Maria Adelaide [UNIFESP]; Sanchez, Raul; Ferreira, Alice Teixeira [UNIFESP]; Schor, Nestor [UNIFESP]; Oshiro, Maria Etsuko Miyamoto [UNIFESP] (Elsevier B.V., 2007-06-01)
      Objective: To determine the effect of arachnotoxin (ATx), a venom extracted from the Chilean spider Latrodectus mactans, on intracellular calcium ([Ca2+](i)) and pH (pH(i)) in capacitated human spermatozoa.Design: Spermatozoa ...

    • Escherichia coli lipopolysaccharide impairs the calcium signaling pathway in mesangial cells: role of angiotensin II receptors 

      Maquigussa, Edgar [UNIFESP]; Arnoni, Carine P. [UNIFESP]; Cristovam, Priscila C. [UNIFESP]; Oliveira, Andrea S. de [UNIFESP]; Higa, Elisa M. S. [UNIFESP]; Boim, Mirian A. [UNIFESP] (Soc Experimental Biology Medicine, 2010-06-01)
      Sepsis causes impaired vascular reactivity, hypotension and acute renal failure. the ability of the Escherichia coli endotoxin (lipopolysaccharide [LPS]) to impair agonist-induced contractility in mesangial cells, which ...

    • The Natural Cell-Penetrating Peptide Crotamine Targets Tumor Tissue in Vivo and Triggers a Lethal Calcium-Dependent Pathway in Cultured Cells 

      Nascimento, Fabio D.; Sancey, Lucie; Pereira, Alexandre; Rome, Claire; Oliveira, Vitor [UNIFESP]; Oliveira, Eduardo B.; Nader, Helena B. [UNIFESP]; Yamane, Tetsuo; Kerkis, Irina; Tersariol, Ivarne L. S.; Coll, Jean-Luc; Hayashi, Mirian A. F. [UNIFESP] (Amer Chemical Soc, 2012-02-01)
      Our goal was to demonstrate the in vivo tumor specific accumulation of crotamine, a natural peptide from the venom of the South American rattlesnake Crotalus durissus terrificus, which has been characterized by our group ...

    • Soluble uric acid increases intracellular calcium through an angiotensin II-dependent mechanism in immortalized human mesangial cells 

      Albertoni, Guilherme [UNIFESP]; Maquigussa, Edgar [UNIFESP]; Pessoa, Edson [UNIFESP]; Barreto, Jose Augusto; Borges, Fernanda [UNIFESP]; Schor, Nestor [UNIFESP] (Soc Experimental Biology Medicine, 2010-07-01)
      Hyperuricemia is associated with increases in cardiovascular risk and renal disease. Mesangial cells regulate glomerular filtration rates through the release of hormones and vasoactive substances. This study evaluates the ...