Now showing items 1-10 of 122

    • Ability of vitamin D to reduce inflammation in adults without acute illness 

      Zanetti, Mayra [UNIFESP]; Harris, Susan S.; Dawson-Hughes, Bess (Wiley-Blackwell, 2014-02-01)
      In vitro studies and some clinical studies suggest that vitamin D plays an important role in reducing inflammation. the objective of this review was to examine recent evidence that vitamin D status influences the level of ...

    • Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis 

      Yoon, Hyesook; Blaber, Sachiko I.; Evans, D. Michael; Trim, Julie; Juliano, Maria Aparecida [UNIFESP]; Scarisbrick, Isobel A.; Blaber, Michael (Cold Spring Harbor Lab Press, Publications Dept, 2008-11-01)
      The human kallikrein-related peptidases (KLKs) comprise 15 members (KLK1-15) and are the single largest family of serine proteases. the KLKs are utilized, or proposed, as clinically important biomarkers and therapeutic ...

    • Ação modulatória da proteína anexina a1 sobre os efeitos do tratamento com anti-tnf em modelo murino de colite experimental 

      Silva, Marina de Paula [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2016-07-26)
      The tumor necrosis factor-alpha (TNF-?) is a key cytokine in the triggering of the inflammatory bowel diseases (IBDs), constituting an interesting target to therapeutic strategies. However, anti-TNF-? drugs, such as the ...

    • Alterations in blood-aqueous barrier after corneal refractive surgery 

      Vita, RCA; Campos, M.; Belfort, R.; Paiva, E. R. (Lippincott Williams & Wilkins, 1998-03-01)
      Purpose. To assess alterations in the blood-aqueous barrier after radial keratotomy (RK), photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK), and phototherapeutic keratectomy (PTK). Methods. Aqueous ...

    • Altered neutrophil homeostasis in kinin B1 receptor-deficient mice 

      Araujo, R. C.; Kettritz, R.; Fichtner, I; Paiva, ACM; Pesquero, J. B.; Bader, M. (Walter de Gruyter & Co, 2001-01-01)
      The kallikrein-kinin system is activated during inflammation and plays a major role in the inflammatory process. One of the main mechanisms of kinin action includes the modulation of neutrophil function employing both ...

    • Amitriptyline attenuates interstitial inflammation and ameliorates the progression of renal fibrosis 

      Achar, Eduardo [UNIFESP]; Maciel, Thiago T. [UNIFESP]; Collares, Carlos F.; Teixeira, Vicente de Paulo Castro [UNIFESP]; Schor, Nestor [UNIFESP] (Nature Publishing Group, 2009-03-01)
      Amitriptyline is a pleiotropic tricyclic antidepressant, which has anti-oxidant and anti-inflammatory properties. We tested whether amitriptyline might be useful in the treatment of chronic renal disease using the mouse ...

    • Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition 

      Dale, Camila Squarzoni; Altier, Christophe; Cenac, Nicolas; Giorgi, Renata; Juliano, Maria Aparecida [UNIFESP]; Juliano, Luiz [UNIFESP]; Zamponi, Gerald W.; Vergnolle, Nathalie (Wiley-Blackwell, 2009-08-01)
      Calcium-binding protein S100A9 and its C-terminus peptide (mS100A9p) are anti-inflammatory and induce antinociception in rodents. We investigated the mechanisms involved in this effect, and whether they depend or not on ...

    • Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia 

      Damazo, Amilcar Sabino [UNIFESP]; Flower, R. J.; Solito, E.; Oliani, S. M. [UNIFESP] (Birkhauser Verlag Ag, 2008-03-01)
      Objective and design: We have previously reported a role for annexin-A1 in liver proliferation and tumorogenicity as well as its action as an acute phase protein in a model of endotoxemia in interleukin-6 null mice.Material ...

    • Anti-inflammatory agents in the treatment of bipolar depression: a systematic review and meta-analysis 

      Rosenblat, Joshua D.; Kakar, Ron; Berk, Michael; Kessing, Lars V.; Vinberg, Maj; Baune, Bernhard T.; Mansur, Rodrigo B. [UNIFESP]; Brietzke, Elisa [UNIFESP]; Goldstein, Benjamin I.; McIntyre, Roger S. (Wiley-Blackwell, 2016)
      ObjectiveInflammation has been implicated in the risk, pathophysiology, and progression of mood disorders and, as such, has become a target of interest in the treatment of bipolar disorder (BD). Therefore, the objective ...

    • Aplicações da bioengenharia tecidual e do potencial antiinflamatório e pró-angiogênico da proteína anexina a1 em heteroenxertos de pele acelular 

      Mimura, Kallyne Kioko [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2016-03-30)
      The development of skin substitutes is essential to overcome the shortage at organs transplantation. Furthermore, the use of drugs to modulate the inflammation and angiogenesis processes is important to the successful ...