Browsing by Subject "indinavir"

Now showing items 1-3 of 3

    • Chronic use of indinavir in albino rat pregnancy (Rattus norvegicus albinus, Rodentia, Mammalia): Biological assay 

      Quintino, Marisa Pascale [UNIFESP]; Nakamura, Mary Uchiyama [UNIFESP]; Simoes, Manuel de Jesus [UNIFESP]; Araujo Junior, Edward [UNIFESP]; Oliveira Filho, Ricardo Martins de [UNIFESP]; Torloni, Maria Regina [UNIFESP]; Espiridião, Silvia [UNIFESP]; Kulay Júnior, Luiz [UNIFESP] (Wiley-Blackwell, 2011-09-01)
      Aim: Assess possible adverse effects of the chronic use of indinavir during pregnancy in a rat model.Methods: 40 pregnant EOM-1 albino rats were randomly allocated into four groups of 10 animals each: a control (Ctr) group ...

    • Comparative studies of two-times-daily versus three-times-daily indinavir in combination with zidovudine and lamivudine 

      Haas, D. W.; Arathoon, E.; Thompson, M. A.; Pedro, R. D.; Gallant, J. E.; Uip, D. E.; Currier, J.; Noriega, L. M.; Lewi, David S. [UNIFESP]; Uribe, P.; Benetucci, J.; Cahn, P.; Paar, D.; White, C. A.; Collier, A. C.; Ramirez-Ronda, C. H.; Harvey, C.; Chung, M.; Mehrotra, D.; Chodakewitz, J.; Nguyen, B. Y.; Protocol 054 069 Study Teams (Lippincott Williams & Wilkins, 2000-09-08)
      Objectives: To compare the efficacy and safety of two-times-daily versus three-times-daily indinavir in combination with zidovudine and lamivudine. Design: Two multicenter, open-label, randomized 24-week studies.Methods: ...

    • Morphological and biochemical appraisal of the liver and renal effects of indinavir on rat pregnancy 

      Quintino, Marisa Pascale [UNIFESP]; Simoes, Ricardo Santos [UNIFESP]; Oliveira, F. H. M.; Oliveira-Filho, Ricardo Martins [UNIFESP]; Simoes, Manuel de Jesus [UNIFESP]; Nakamura, Mary Uchiyama [UNIFESP]; Kulay Júnior, Luiz [UNIFESP] (I R O G Canada, Inc, 2007-01-01)
      Since indinavir is currently used in combination with other antiretroviral agents, there is a scarcity of studies in the literature on its single-drug perinatal safety. Thus, we decided to examine the gross maternal and ...