Browsing by Subject "haplotype"

Now showing items 1-3 of 3

    • Association Between Interleukin 6 Gene Haplotype and Alzheimer's Disease: A Brazilian Case-Control Study 

      Rasmussen, Lucas [UNIFESP]; Delabio, Roger; Horiguchi, Lie; Mizumoto, Igor; Terazaki, Carlos-Renato; Mazzotti, Diego [UNIFESP]; Bertolucci, Paulo-Henrique [UNIFESP]; Pinhel, Marcela-Augusta; Souza, Doroteia; Krieger, Henrique; Kawamata, Carlos; Minett, Thais; Smith, Marilia Cardoso [UNIFESP]; Payao, Spencer-Luiz (Ios Press, 2013-01-01)
      Alzheimer's disease (AD) is a progressive neurodegenerative disease that takes the form of a local overexpression of cytokines and other inflammatory molecules. We investigated three single-nucleotide polymorphisms (SNP) ...

    • Independent mutational events are rare in the ATM gene: Haplotype prescreening enhances mutation detection rate 

      Mitui, M.; Campbell, C.; Coutinho, G.; Sun, X; Lai, C. H.; Thorstenson, Y.; Castellvi-Bel, S.; Fernandez, L.; Monros, E.; Carvalho, BTC; Porras, O.; Fontan, G.; Gatti, R. A. (Wiley-Blackwell, 2003-07-01)
      Mutations in the ATM gene are responsible for the autosomal recessive disorder ataxia,telangiectasia (A-T). Many different mutations have been identified using various techniques, with detection efficiencies ranging from ...

    • A novel strategy for defining haplotypes by selective depletion using restriction enzymes 

      Smirnova, Anna S.; Ferreira-Silva, Katia C.; Mine, Karina L.; Andrade-Oliveira, Vinicius; Shulzhenko, Natalia; Gerbase-DeLima, Maria; Morgun, Andrey (Springer, 2007-01-01)
      Various single nucleotide polymorphisms (SNPs) have been investigated regarding association with gene expression levels or human diseases. Although different SNPs within one gene are frequently analyzed individually, it ...