Browsing by Subject "gene therapy"

Now showing items 1-10 of 19

    • alpha-L-iduronidase gene-based therapy using the phiC31 system to treat mucopolysaccharidose type I mice 

      Stilhano, Roberta Sessa [UNIFESP]; Martin, Priscila Keiko Matsumoto [UNIFESP]; Melo, Suely Maymone de [UNIFESP]; Samoto, Vivian Yochiko [UNIFESP]; Peres, Giovani Bravin [UNIFESP]; Michelacci, Yara Maria [UNIFESP]; Silva, Flavia Helena da [UNIFESP]; Pereira, Vanessa Gonçalves [UNIFESP]; D'Almeida, Vania [UNIFESP]; Cruz, Adriana Taveira da [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Han, Sang Won [UNIFESP] (Wiley-Blackwell, 2015-01-01)
      BackgroundMucopolysaccharidose type I (MPSI) is a lysosomal monogenic disease caused by mutations in the gene for - l-iduronidase (IDUA). MPSI patients need a constant supply of IDUA to alleviate progression of the disease. ...

    • Anti-tumor effect of endostatin mediated by retroviral gene transfer in mice bearing renal cell carcinoma 

      Coutinho, Enia Lucia [UNIFESP]; Andrade, Luciana Nogueira de Sousa; Chammas, Roger; Morganti, Ligia; Schor, Nestor [UNIFESP]; Bellini, Maria Helena [UNIFESP] (Federation Amer Soc Exp Biol, 2007-10-01)
      We investigated whether transfer of the gene encoding the angiogenesis inhibitor endostatin into the NIH/3T3 fibroblast cell line could inhibit renal tumor growth in vivo. NIH/3T3 cells were transduced with retroviral ...

    • Comparison of treatments of peripheral arterial disease with mesenchymal stromal cells and mesenchymal stromal cells modified with granulocyte and macrophage colony-stimulating factor 

      Cunha, Flavia Franco da [UNIFESP]; Martins, Leonardo [UNIFESP]; Matsumoto Martin, Priscila Keiko [UNIFESP]; Stilhano, Roberta Sessa [UNIFESP]; Paredes-Gamero, Edgar Julian [UNIFESP]; Han, Sang Won [UNIFESP] (Informa Healthcare, 2013-07-01)
      Background aims. Granulocyte macrophage-colony stimulating factor (GM-CSF) promotes vessel formation through several molecular signaling pathways. Mesenchymal stromal cells (MSCs) have an important role in neovasculogenesis ...

    • Correction of Monogenic and Common Retinal Disorders with Gene Therapy 

      Sengillo, Jesse D.; Justus, Sally; Cabral, Thiago [UNIFESP]; Tsang, Stephen H. (Mdpi, 2017)
      The past decade has seen major advances in gene-based therapies, many of which show promise for translation to human disease. At the forefront of research in this field is ocular disease, as the eye lends itself to gene-based ...

    • CRISPR-Cas Genome Surgery in Ophthalmology 

      DiCarlo, James E.; Sengillo, Jesse D.; Justus, Sally; Cabral, Thiago [UNIFESP]; Tsang, Stephen H.; Mahajan, Vinit B. (Assoc Research Vision Ophthalmology Inc, 2017)
      Genetic disease affecting vision can significantly impact patient quality of life. Gene therapy seeks to slow the progression of these diseases by treating the underlying etiology at the level of the genome. Clustered ...

    • Cytotoxic T cells and mycobacteria 

      Silva, Celio L.; Bonato, Vania LD; Lima, Karla M.; Coelho-Castelo, Arlete AM; Faccioli, Lucia H.; Sartori, Alexandrina; De Souza, Ana O.; Leao, Sylvia Cardoso [UNIFESP] (Elsevier B.V., 2001-04-01)
      How the immune system kills Mycobacterium tuberculosis is still a puzzle. the classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here ...

    • DOUBLE GENE THERAPY WITH GRANULOCYTE COLONY-STIMULATING FACTOR and VASCULAR ENDOTHELIAL GROWTH FACTOR ACTS SYNERGISTICALLY TO IMPROVE NERVE REGENERATION and FUNCTIONAL OUTCOME AFTER SCIATIC NERVE INJURY in MICE 

      Lopes, F. R. Pereira; Martin, P. K. M. [UNIFESP]; Frattini, F.; Biancalana, A.; Almeida, F. M.; Tomaz, M. A.; Melo, P. A.; Borojevic, R.; Hans, S. W.; Martinez, A. M. B. (Elsevier B.V., 2013-01-29)
      Peripheral-nerve injuries are a common clinical problem and often result in long-term functional deficits. Reconstruction of peripheral-nerve defects is currently undertaken with nerve autografts. However, there is a limited ...

    • Electroporation of Vascular Endothelial Growth Factor Gene in a Unipedicle Transverse Rectus Abdominis Myocutaneous Flap Reduces Necrosis 

      Rezende, Fernando C. [UNIFESP]; Gomes, Heitor C.; Lisboa, Bianca; Lucca, Aldrein F. [UNIFESP]; Han, Sang W.; Ferreira, Lydia M. (Lippincott Williams & Wilkins, 2010-02-01)
      Necrosis in TRAM (transverse rectus abdominis myocutaneous) still occurs in flap breast reconstruction. Blood flow may be improved by vascular endothelial growth factor (VEGF), an endogenous protein that stimulates ...

    • Endostatin- and interleukin-2-expressing retroviral bicistronic vector for gene therapy of metastatic renal cell carcinoma 

      Goes Rocha, Flavia Gomes de [UNIFESP]; Calvo, Fernanda B.; Chaves, Karen C. [UNIFESP]; Peron, Jean P. S.; Marques, Rodolfo F.; Borba, Tania R. de; Braga, Marina S.; Pereira, Cleide B.; Vicente, Elisabete J.; Chammas, Roger; Schor, Nestor [UNIFESP]; Bellini, Maria H. [UNIFESP] (Wiley-Blackwell, 2011-03-01)
      Background Metastatic renal cell carcinoma (mRCC) is one of the most treatment-resistant malignancies. Despite all new therapeutic advances, almost all patients develop resistance to treatment and cure is rarely seen. in ...

    • Enhancement of sciatic nerve regeneration after vascular endothelial growth factor (VEGF) gene therapy 

      Pereira Lopes, F. R.; Lisboa, B. C. G. [UNIFESP]; Frattini, F.; Almeida, F. M.; Tomaz, M. A.; Matsumoto, P. K. [UNIFESP]; Langone, F.; Lora, S.; Melo, P. A.; Borojevic, R.; Han, S. W. [UNIFESP]; Martinez, A. M. B. (Wiley-Blackwell, 2011-10-01)
      Aims: Recent studies have emphasized the beneficial effects of the vascular endothelial growth factor (VEGF) on neurone survival and Schwann cell proliferation. VEGF is a potent angiogenic factor, and angiogenesis has long ...