Browsing by Subject "excitotoxicity"

Now showing items 1-2 of 2

    • Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions 

      Fighera, M. R.; Queiroz, C. M.; Stracke, M. P.; Brauer, MCN; Gonzalez-Rodriguez, L. L.; Frussa, R.; Wajner, M.; Mello, C. F. de (Lippincott Williams & Wilkins, 1999-07-13)
      THE effects of chronic administration of alpha-tocopherol or melatonin, or acute ascorbic acid administration on the convulsant action of methylmalonic acid (MMA) were investigated in adult male rats. Animals were chronically ...

    • Glutamate-induced alterations in Ca2+ signaling are modulated by mitochondrial Ca2+ handling capacity in brain slices of R6/1 transgenic mice 

      Rosenstock, T. R. [UNIFESP]; Bertoncini, C. R. A. [UNIFESP]; Teles, A. V. [UNIFESP]; Hirata, H. [UNIFESP]; Fernandes, M. J. S. [UNIFESP]; Smaili, Soraya Soubhi [UNIFESP] (Wiley-Blackwell, 2010-07-01)
      Huntington's disease is a neurodegenerative disorder caused by an expansion of CAGs repeats and characterized by alterations in mitochondrial functions. Although changes in Ca2+ handling have been suggested, the mechanisms ...