Now showing items 1-5 of 5

    • Crystal structure of a novel cysteinless plant Kunitz-type protease inhibitor 

      Hansen, Daiane; Macedo-Ribeiro, Sandra; Verissimo, Paula; Im, Sonia Yoo; Sampaio, Misako Uemura; Oliva, Maria Luiza Vilela (Elsevier B.V., 2007-09-07)
      Bauhinia bauhinioides Cruzipain Inhibitor (BbCI) is a cysteine protease inhibitor highly homologous to plant Kunitz-type inhibitors. However, in contrast to classical Kunitz family inhibitors it lacks cysteine residues and ...

    • Efeito de inibidores de proteinases extraídos de plantas brasileiras em modelo de úlcera gástrica, em ratos e camundongos 

      Valois, Mayara Vioto [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2013-03-27)
      Proteinases desempenham papel importante em várias vias de sinalização. Inibidores, cujo alvo são proteinases com papel bem estabelecido, apresentam sucesso como estratégias terapêuticas. Neste estudo, foram utilizados ...

    • Effect of plant neutrophil elastase inhibitor on leucocyte migration, adhesion and cytokine release in inflammatory conditions 

      Oliveira, C. [UNIFESP]; Navarro-Xavier, R. A.; Anjos-Vallota, E. A.; Martins, J. O.; Silveira, Vera Lucia Flor [UNIFESP]; Goncalves, L. R. C.; Araujo, M. S. [UNIFESP]; Motta, G. [UNIFESP]; Sannomiya, P.; Oliva, Maria Luiza Vilela [UNIFESP] (Wiley-Blackwell, 2010-10-01)
      BACKGROUND and PURPOSEThe serine and cysteine peptidase inhibitor, BbCI, isolated from Bauhinia bauhinioides seeds, is similar to the classical plant Kunitz inhibitor, STI, but lacks disulphide bridges and methionine ...

    • Endovascular model of abdominal aortic aneurysm induction in swine 

      Lederman, Alex; Saliture Neto, Fernando Tavares; Ferreira, Rimarcs [UNIFESP]; Figueiredo, Luis Francisco Poli de; Otoch, Jose Pinhata; Aun, Ricardo; Silva, Erasmo Simao da (Sage Publications Ltd, 2014-06-01)
      Abdominal aortic aneurysms are among the main causes of death. the high morbidity and mortality associated with aneurysm rupture and repair represents a challenge for surgeons and high risk for patients. Although experimental ...

    • Kunitz-type Bauhinia bauhinioides inhibitors devoid of disulfide bridges: isolation of the cDNAs, heterologous expression and structural studies 

      Araujo, APU; Hansen, D.; Vieira, D. F.; Oliveira, C. de; Santana, L. A.; Beltramini, L. M.; Sampaio, CAM; Sampaio, M. U.; Oliva, MLV (Walter de Gruyter & Co, 2005-06-01)
      Bauhinia bauhinoides cruzipain inhibitor (BbCl) and Bauhinia bauhinioides kallikrein inhibitor (BbKl) are cysteine and serine proteinase inhibitors structurally homologous to plant Kunitz-type inhibitors, but are devoid ...