Browsing by Subject "diabetic nephropathy"

ACE-Dependent and chymase-dependent angiotensin II generation in normal and glucose-stimulated human mesangial cells

Cristovam, Priscila C. [UNIFESP]; Arnoni, Carine P. [UNIFESP]; De Andrade, Maria Claudina C. [UNIFESP]; Casarini, Dulce E. [UNIFESP]; Pereira, Luciana G. [UNIFESP]; Schor, Nestor [UNIFESP]; Boim, Mirian A. [UNIFESP] (Soc Experimental Biology Medicine, 2008-08-01)

High glucose (HG) increases angiotensin II (AngII) generation in mesangial cells (MC). Chymase, an alternative AngII-generating enzyme, is upregulated in the glomeruli of diabetic kidneys. in this study, we examined AngII ...

Different urinary albumin responses to submaximal exercise by normoalbuminuric diabetic children and controls

Cesarini, Paulo Roberto [UNIFESP]; Ferreira, Sandra Roberta Gouvea [UNIFESP]; Vivolo, Marco Antonio [UNIFESP]; Zanella, Maria Teresa [UNIFESP] (Assoc Bras Divulg Cientifica, 1996-12-01)

It is not clear if exercise could be useful to identify diabetic patients at risk for the development of nephropathy. We evaluated the responses of blood pressure (BP) and urinary albumin (Alb) and retinol-binding protein ...

Effect of long-term type 1 diabetes on renal sodium and water transporters in rats

Vidotti, Daniela B. [UNIFESP]; Arnoni, Carine P. [UNIFESP]; Maquigussa, Edgar [UNIFESP]; Boim, Mirian A. [UNIFESP] (Karger, 2008-01-01)

The effects of long-term diabetes in the presence of established nephropathy on tubular function remains poorly understood. We evaluated the levels of the main sodium and water transport proteins expressed in the kidney ...

Effects of training and nitric oxide on diabetic nephropathy progression in type I diabetic rats

Rodrigues, Adelson M. [UNIFESP]; Bergamaschi, Cassia T. [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Mouro, Margaret G. [UNIFESP]; Rosa, Thiago S. [UNIFESP]; Higa, Elisa M. S. [UNIFESP] (Royal Soc Medicine Press Ltd, 2011-10-01)

The aim of the paper is to assess nitric oxide (NO) production during aerobic training and its role on the progression of diabetic nephropathy in rats. Induction of diabetes mellitus (DM) was achieved in adult male Wistar ...

Estudo da modulação das células mielóides supressoras no adenocarcinoma metastático após terapia influência do treinamento físico combinado nas vias de sinalização da mtor e da pgc-1alfa

Jorge, Luciana [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2016-06-30)

Diabetes Mellitus (DM) is a multifactorial disease resulting from either failure in the secretion of insulin, and in the commitment of its action, leading to hyperglycemia and producing changes in the metabolism of ...

Factors associated with the development of renal complications of diabetes mellitus in Sao Paulo city

Ferreira, Sandra Roberta Gouvea [UNIFESP]; Pinto, Flavio Mendonca [UNIFESP] (Assoc Bras Divulg Cientifica, 1997-06-01)

The incidence of diabetic end-stage renal failure (ESRF) varies worldwide and risk factors have been demonstrated in several populations. The objective of the present study was to identify possible factors associated with ...

Functional, biochemical, and molecular investigations of renal kallikrein-kinin system in diabetic rats

Tschope, C.; Reinecke, A.; Seidl, U.; Yu, M.; Gavriluk, V; Riester, U.; Gohlke, P.; Graf, K.; Bader, M.; Hilgenfeldt, U.; Pesquero, João Bosco [UNIFESP]; Ritz, E.; Unger, T. (Amer Physiological Soc, 1999-12-01)

A reduction of renal kallikrein has been found in non-insulin-treated diabetic individuals, suggesting that an impaired renal kallikreinkinin system (KKS) contributes to the development of diabetic nephropathy. We analyzed ...

High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells

Vidotti, D. B.; Casarini, D. E.; Cristovam, P. C.; Leite, C. A.; Schor, N.[UNIFESP]; Boim, M. A. (Amer Physiological Soc, 2004-06-01)

Increased intrarenal renin-angiotensin system activity contributes to diabetic nephropathy. ANG II generation in mesangial cells (MC) is increased by high-glucose (HG) exposure. This study assessed the mechanisms involved ...

ID1 inhibits USF2 and blocks TGF-beta-induced apoptosis in mesangial cells

Simoes Sato, Alex Yuri; Antonioli, Eliane; Tambellini, Rodrigo [UNIFESP]; Campos, Alexandre Holthausen (Amer Physiological Soc, 2011-12-01)

Sato AY, Antonioli E, Tambellini R, Campos AH. ID1 inhibits USF2 and blocks TGF-beta-induced apoptosis in mesangial cells. Am J Physiol Renal Physiol 301: F1260-F1269, 2011. First published September 14, 2011; doi: ...

Regulation of Glucose Uptake in Mesangial Cells Stimulated by High Glucose: Role of Angiotensin II and Insulin

Arnoni, Carine P. [UNIFESP]; Lima, Carla [UNIFESP]; Cristovam, Priscila C. [UNIFESP]; Maquigussa, Edgar [UNIFESP]; Vidotti, Daniela B. [UNIFESP]; Boim, Mirian A. [UNIFESP] (Soc Experimental Biology Medicine, 2009-09-01)

Mesangial cells (MCs) play a central role in the pathogenesis of diabetic nephropathy (DN). MC dysfunction arises from excessive glucose uptake through insulin-independent glucose transporter (GLUT1). the role of the ...