Browsing by Subject "cytotoxicity"

Now showing items 1-10 of 12

    • Brown spider dermonecrotic toxin directly induces nephrotoxicity 

      Chaim, O. M.; Sade, Y. B.; Silveira, R. B. da; Toma, L.; Kalapothakis, E.; Chavez-Olortegui, C.; Mangili, O. C.; Gremski, W.; von Dietrich, C. P.; Nader, H. B.; Veiga, S. S. (Elsevier B.V., 2006-02-15)
      Brown spider (Loxosceles genus) venom can induce dermonecrotic lesions at the bite site and systemic manifestations including fever, vomiting, convulsions, disseminated intravascular coagulation, hemolytic anemia and acute ...

    • Chromomycin A2 Induces Autophagy in Melanoma Cells 

      Guimaraes, Larissa Alves; Jimenez, Paula Christine [UNIFESP]; Silva Sousa, Thiciana da; Freitas, Hozana Patricia S.; Rocha, Danilo Damasceno; Wilke, Diego Veras; Martin, Jesus; Reyes, Fernando; Loiola Pessoa, Otilia Deusdenia; Costa-Lotufo, Leticia Veras (Mdpi Ag, 2014-12-01)
      The present study highlights the biological effects of chromomycin A2 toward metastatic melanoma cells in culture. Besides chromomycin A2, chromomycin A3 and demethylchromomycin A2 were also identified from the extract ...

    • Cyclopalladated compounds containing 2,6-dimethylpyridine: Synthesis and cytotoxicity against human melanoma cell lines 

      Netto, Adelino V. G.; Cunha, Gislaine A.; Mauro, Antonio E.; Garcia, Daniel M. [UNIFESP]; Spindola, Daniel G. [UNIFESP]; Michelin, Luis F.G. [UNIFESP]; Bincoletto, Claudia [UNIFESP]; Deflon, Victor (Springer, 2017)

    • Cytokine profile in response to Cytomegalovirus associated with immune recovery syndrome after highly active antiretroviral therapy 

      Rios, L. S.; Vallochi, A. L.; Muccioli, Cristina [UNIFESP]; Campos-Machado, M. A.; Belfort, Rubens Junior [UNIFESP]; Rizzo, L. V. (Canadian Ophthal Soc, 2005-12-01)
      Background: Several changes have occurred in the presentation and course of cytomegalovirus (CMV) retinitis in patients with AIDS since the introduction of HAART (highly active antiretroviral therapy). In some individuals ...

    • Development of a Sustained-release System for Nitric Oxide Delivery using Alginate/Chitosan Nanoparticles 

      Marcato, Priscyla D.; Adami, Leonardo F.; Barbosa, Raquel de Melo; Melo, Patricia S.; Ferreira, Iasmin R.; Paula, Larissa de; Duran, Nelson; Seabra, Amedea Barozzi [UNIFESP] (Bentham Science Publ Ltd, 2013-02-01)
      Free radical nitric oxide (NO) has been known to interact with various physiological processes, such as wound repair processes and control of vascular tone. However, NO is an unstable molecule and the development of NO ...

    • Implementation of the Three Rs in the Human Hazard Assessment of Brazilian Medicinal Plants: An Evaluation of the Cytotoxic and Genotoxic Potentials of Dipteryx alata Vogel 

      Esteves-Pedro, Natalia M.; Rodas, Andrea C. D.; Dal Belo, Chariston A.; Oshima-Franco, Yoko; Santos, Marcio G. dos; Lopes, Patricia Santos [UNIFESP] (Frame, 2011-05-01)
      In Brazil, medicinal plants are widely used by the indigenous people, which leads to a constant requirement for toxicity tests to be performed on the plant extracts. Although the current Brazilian Directive 90/2004 on the ...

    • Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth 

      Jasiulionis, Miriam G.; Luchessi, Augusto D.; Moreira, Andreia G.; Souza, Pedro P. C.; Suenaga, Ana P. M.; Correa, Mariangeta; Costa, Carlos A. S.; Curi, Rui; Costa-Neto, Claudio M. (Wiley-Blackwell, 2007-01-01)
      The eukaryotic translation initiation factor 5A (eIF5A) undergoes a specific post-translational modification called hypusination. This modification is required for the functionality of this protein. the compound ...

    • Porous stainless steel for biomedical applications 

      Mariotto, Sabrina de Fátima Ferreira; Guido, Vanessa; Yao Cho, Liu; Soares, Cristina Pacheco; Cardoso, Kátia Regina [UNIFESP] (ABM, ABC, ABPol, 2011-01-01)
      Porous 316L austenitic stainless steel was synthesized by powder metallurgy with relative density of 0.50 and 0.30 using 15 and 30 wt. (%) respectively of ammonium carbonate and ammonium bicarbonate as foaming agents. The ...

    • Prospects of Nanostructure Materials and Their Composites as Antimicrobial Agents 

      Baranwal, Anupriya; Srivastava, Ananya; Kumar, Pradeep; Bajpai, Vivek K.; Maurya, Pawan K. [UNIFESP]; Chandra, Pranjal (Frontiers Media Sa, 2018)
      Nanostructured materials (NSMs) have increasingly been used as a substitute for antibiotics and additives in various products to impart microbicidal effect. In particular, use of silver nanoparticles (AgNPs) has garnered ...

    • Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo 

      Figueiredo, Carlos Rogerio [UNIFESP]; Matsuo, Alisson Leonardo [UNIFESP]; Pereira, Felipe Valença [UNIFESP]; Rabaca, Aline Nogueira [UNIFESP]; Farias, Camyla Fernandez de [UNIFESP]; Girola, Natalia [UNIFESP]; Massaoka, Mariana Hiromi [UNIFESP]; Azevedo, Ricardo Alexandre de [UNIFESP]; Scutti, Jorge Augusto Borin [UNIFESP]; Arruda, Denise Costa [UNIFESP]; Silva, Luciana Pereira; Rodrigues, Elaine Guadelupe [UNIFESP]; Lago, Joao Henrique Ghilardi [UNIFESP]; Travassos, Luiz Rodolpho [UNIFESP]; Silva, Regildo Márico Gonçalves da (Medknow Publications & Media Pvt Ltd, 2014-05-01)
      Background: Pyrostegia venusta (Ker. Gawl.) Miers (Bignoniacea) is a medicinal plant from the Brazilian Cerrado used to treat leucoderma and common diseases of the respiratory system. Objective: To investigate the antitumor ...