Browsing by Subject "cyclosporine"

Now showing items 1-10 of 20

    • Chronopharmacokinetics of Mycophenolic Acid and Its Glucuronide and Acyl Glucuronide Metabolites in Kidney Transplant Recipients Converted From Cyclosporine to Everolimus 

      Tedesco-Silva, Helio [UNIFESP]; Felipe, Claudia Rosso [UNIFESP]; Slade, Alan; Schmouder, Robert L.; Medina Pestana, Jose Osmar [UNIFESP] (Lippincott Williams & Wilkins, 2012-12-01)
      Background: the influence of the conversion from cyclosporine (CsA) to everolimus (EVR) on the chronopharmacokinetics of mycophenolic acid (MPA) and its glucuronide (MPAG) and acyl glucuronide (acyl-MPAG) metabolites in ...

    • Concentration-controlled use of sirolimus associated with reduced exposure of cyclosporine in black recipients of primarily living renal allograft donors: 12-month results 

      Ferreira, A. N.; Machado, P. G.; Felipe, C. R.; Motegi, S. A.; Hosaka, B. H.; Tanaka, M. K.; Kamura, L. A.; Park, S. I.; Garcia, R.; Franco, M.; Alfieri, F.; Casarini, D. E.; Tedesco-Silva, H.; Medina-Pestana, J. O. (Blackwell Publishing, 2005-10-01)
      Aim: This study was designed to identify optimal therapeutic sirolimus (SRL) concentrations in black kidney transplant recipients on reduced cyclosporine (CsA) exposure and prednisone.Methods: Seventy patients (64 living/six ...

    • Cyclosporine A in juvenile idiopathic arthritis. Results of the PRCSG/PRINTO phase IV post marketing surveillance study 

      Ruperto, N.; Ravelli, A.; Castell, E.; Gerloni, V.; Haefner, R.; Malattia, C.; Kanakoudi-Tsakalidou, F.; Nielsen, S.; Bohnsack, J.; Gibbas, D.; Rennebohm, R.; Voygioyka, O.; Balogh, Z.; Lepore, L.; Macejkova, E.; Wulffraat, N.; Oliveira, S.; Russo, R.; Buoncompagni, A.; Hilário, Maria Odete Esteves [UNIFESP]; Alpigiani, M. G.; Passo, M.; Lovell, D. J.; Merino, R.; Martini, A.; Giannini, E. H.; PRCSG; PRINTO (Clinical & Exper Rheumatology, 2006-09-01)
      ObjectiveTo investigate the clinical use patterns, clinical effect and safety of cyclosporine A (CSA) in juvenile idiopathic arthritis (JIA) in the setting of routine clinical care.MethodsAn open-ended, phase IV post ...

    • Cyclosporine and sirolimus pharmacokinetics and drug-to-drug interactions in kidney transplant recipients 

      Felipe, Claudia R. [UNIFESP]; Park, Sung-In [UNIFESP]; Pinheiro-Machado, Paula G. [UNIFESP]; Garcia, Riberto [UNIFESP]; Casarini, Dulce E. [UNIFESP]; Moreira, Silvia [UNIFESP]; Tedesco-Silva, Helio [UNIFESP]; Medina-Pestana, Jose O. [UNIFESP] (Wiley-Blackwell, 2009-10-01)
      This study was conducted to evaluate the pharmacokinetics (pk) and drug interactions between cyclosporine (CsA) and sirolimus (SRL) in kidney transplant recipients. the morning (a.m.) and evening (p.m.) pk of CsA (4-5 ...

    • Effects of topical 2% cyclosporine A on the corneas of dogs subjected to lamellar keratoplasty with a graft of equine pericardium preserved in glycerin: clinical and morphological evaluation 

      Teixeira, Roseli Borges; Barros, Paulo Sergio De Moraes; Martins, Maria Cristina [UNIFESP] (Universidade Federal de Santa Maria, 2004-02-01)
      The effects of topical 2% cyclosporine A on the cornea of dogs subjected to experimental lamellar keratoplasty with an equine pericardial graft were evaluated. Ten dogs were grouped to be evaluated 3, 7, 15, 30 and 60 days ...

    • Fructose-1,6-diphosphate: Potential protection in cyclosporine-induced renal impairment 

      Cardoso, Lucio Ronaldo; Santos, Oscar Fernando Pavão dos [UNIFESP]; Boim, Mirian Aparecida [UNIFESP]; Barros, Elvino José Guardião; Ajzen, Horacio [UNIFESP]; Schor, Nestor [UNIFESP] (Karger, 1996-01-01)
      There is evidence that fructose-1,6-diphosphate (FDP) provides protection from hepatic and cardiac toxic-induced damage and ischemic renal insult. To determine ifFDP also protects against cyclosporine (CsA)-induced ...

    • FTY720 versus mycophenolate mofetil in de novo renal transplantation: Six-month results of a double-blind study 

      Tedesco-Silva, Helio; Szakaly, Peter; Shoker, Ahmed; Sommerer, Claudia; Yoshimura, Norio; Schena, Francesco Paolo; Cremer, Malika; Hmissi, Abdel; Mayer, Hartmut; Lang, Philippe; FTY720 2218 Clinical Study Grp (Lippincott Williams & Wilkins, 2007-10-15)
      Background. FTY720 is a novel immunomodulator that was developed to produce optimal graft protection with improved safety and tolerability. Phase II studies have demonstrated the efficacy of FTY720 up to the doses of 2.5 ...

    • Heme oxygenase 1 and renal ischemia and reperfusion injury: the impact of immunosuppressive drug 

      Goncalves, Giselle Martins; Cenedeze, Marcos Antonio; Feitoza, Carla Quarim; Paula, Carolina Batista de; Macusso, Georgia Daniela; Pinheiro, Helady Sanders; Antunes Teixeira, Vicente de Paula; Reis, Marlene Antonia dos; Pacheco-Silva, Alvaro; Camara, Niels Olsen Saraiva (Elsevier B.V., 2006-12-20)
      Background: Ischemia and reperfusion injury (IRI) is the main etiology of acute renal failure in native and transplanted kidneys. in the transplantation field, immunosuppressive drugs may play an additional role in acute ...

    • HSP70 induced by hyperosmotic stress partially protects LLC-PK1 cells against nephrotoxic drugs 

      Leitao, A. A.; Leite, C. A.; Santos, B. C.; Boim, M. A. (Karger, 2003-07-01)
      Accumulation of HSP70 is related to the cytoprotection. It was evaluated whether hyperosmotic stress induces HSP70 accumulation in LLC-PK1 cells, and protects cells against toxicity provoked by cisplatin (Cis) and cyclosporine ...

    • Influence of cyclosporine A on mucociliary system after lung transplantation in rats 

      Xavier, Alexandre Martins [UNIFESP]; Pego-Fernandes, Paulo Manuel; Correia, Aristides Tadeu; Pazetti, Rogerio; Monteiro, Rosangela; Canzian, Mauro [UNIFESP]; Jatene, Fabio Biscegli (Acta Cirurgica Brasileira, 2007-11-01)
      Purpose: To investigate the function of the bronchial mucociliary system in transplanted rat lungs with and without the influence of immunosuppression. Methods: Thirty-six rats underwent single-lung transplantation and ...