Browsing by Subject "convulsion"
Now showing items 1-5 of 5
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Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions
(Lippincott Williams & Wilkins, 1999-07-13)THE effects of chronic administration of alpha-tocopherol or melatonin, or acute ascorbic acid administration on the convulsant action of methylmalonic acid (MMA) were investigated in adult male rats. Animals were chronically ...
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GM1 ganglioside attenuates convulsions and thiobarbituric acid reactive substances production induced by the intrastriatal injection of methylmalonic acid
(Elsevier B.V., 2003-04-01)The effects of the administration of monosialoganglioside (GM1) on methylmalonic acid (MMA)-induced convulsions, production of thiobarbituric acid reactive substances (TBARS) and on the striatal content of ascorbic acid ...
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Intrastriatal methylmalonic acid administration induces convulsions and TBARS production, and alters Na+,K+-ATPase activity in the rat striatum and cerebral cortex
(Blackwell Publishing Inc, 2003-06-01)Purpose: Methylmalonic acid (MMA) inhibits succinate dehydrogenase (SDH) and beta-hydroxybutyrate dehydrogenase activity in vitro. Acute intrastriatal administration of MMA induces convulsions through glutamatergic mechanisms ...
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Involvement of NO in the convulsive behavior and oxidative damage induced by the intrastriatal injection of methylmalonate
(Elsevier B.V., 2005-03-11)Acute intrastriatal administration of methylmalonic acid (MMA) induces convulsions through NMDA receptor-mediated mechanisms and increases production of end products of oxidative damage. Although it has been demonstrated ...
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Succinate increases neuronal post-synaptic excitatory potentials in vitro and induces convulsive behavior through N-methyl-D-aspartate-mediated mechanisms
(Elsevier B.V., 2004-01-01)Succinate is a dicarboxylic acid that accumulates due to succinate dehydrogenase inhibition by malonate and methylmalonate exposure. These neurotoxins cause increased excitability and excitotoxic damage, which can be ...
