Now showing items 1-10 of 10

    • Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, Southern Brazil 

      Zannin, Marlene; Lourenco, Dayse Maria [UNIFESP]; Motta, Guacyara [UNIFESP]; Dalla Costa, Luís R.; Grando, Maargareth; Gamborgi, Geni P.; Noguti, Maria A. [UNIFESP]; Chudzinski-Tavassi, Ana M. (Schattauer Gmbh-verlag Medizin Naturwissenschaften, 2003-02-01)
      Haemostatic disorders caused by Lonomia obliqua caterpillars has reached epidemic proportions in southern Brazil. Here we evaluated coagulation and fibrinolysis in 105 patients after accidental contact with Lonomia obliqua ...

    • Cytokine gene variants and venous thrombotic risk in the BRATROS (BRAZILIAN THROMBOSIS STUDY) 

      Pieroni, Fabiano; Lourenco, Dayse M.; Morelli, Vania M.; Maffei, Francisco H.; Zago, Marco A.; Franco, Rendrik F. (Elsevier B.V., 2007-01-01)
      Introduction: Venous thrombosis (VT) and inflammation are two closely related entities. in the present investigation we assessed whether there is a relation between genetic modifiers of the inflammatory response and the ...

    • Evaluation of the changes on hemostatic parameters induced by valdecoxib in male Wistar rats 

      Fronza, Marcio; Wrasse, Micheli; Brum Junior, Liberato; Sangoi, Maximiliano S.; Dalmora, Sérgio L. [UNIFESP] (Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2006-03-01)
      The effects of the cyclooxygenase (COX)-2 selective inhibitor, valdecoxib, on blood coagulation parameters were evaluated, along with aspirin in male Wistar rats. Groups of animals were administered a daily oral dose of ...

    • Insularinase A, a prothrombin activator from Bothrops insularis venom, is a metalloprotease derived from a gene encoding protease and disintegrin domains 

      Modesto, JCD; Junqueira-de-Azevedo, ILM; Neves-Ferreira, AGC; Fritzen, M.; Oliva, MLV; Ho, P. L.; Perales, J.; Chudzinski-Tavassi, A. M. (Walter de Gruyter Gmbh, 2005-06-01)
      The first low-molecular-mass metalloprotease presenting prothrombin activating activity was purified from Bothrops insularis venom and named insularinase A. It is a single-chain protease with a molecular mass of 22 639 Da. ...

    • Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies 

      Martinez, José Antônio Baddini [UNIFESP]; Guerra, Celso Carlos de Campos [UNIFESP]; Nery, Luiz Eduardo [UNIFESP]; Jardim, José Roberto [UNIFESP] (Associação Paulista de Medicina - APM, 1997-04-01)
      This study was designed to determine the effects of phlebotomy on iron body contents and coagulation tests of COPD patients with polycythemia secondary to hypoxemia. Seventeen patients with COPD and hematocrits higher than ...

    • Nitridergic platelet pathway activation by hementerin, a metalloprotease from the leech Haementeria depressa 

      Chudzinski-Tavassi, A. M.; Bermejo, E.; Rosenstein, R. E.; Faria, F.; Sarmiento, MIK; Alberto, F.; Sampaio, M. U.; Lazzari, M. A. (Walter de Gruyter & Co, 2003-09-01)
      Hementerin (HT) is an 80 kDa fibrino(geno)lytic metalloprotease, purified from saliva of the leech Haementeria depressa. in the present report, the effect of HT on several functional parameters of human platelets was ...

    • Plasma proteins of hemostasis in the hepatointestinal form of schistosomiasis mansoni 

      CamachoLobato, L.; Borges, D. R. (Lippincott-raven Publ, 1996-09-01)
      The hepatosplenic form of schistosomiasis mansoni is associated with impairment of blood coagulation, a result of reduced synthesis of clotting factors and inhibitors, enhanced fibrinolytic activity, or ''consumption'' of ...

    • Proteinase inhibitors in Brazilian leguminosae 

      Sampaio, Claudio Augusto Machado [UNIFESP]; Oliva, Maria Luiza Vilela [UNIFESP]; Tanaka, Aparecida Sadae [UNIFESP]; Sampaio, Misako Uemura [UNIFESP] (Instituto Oswaldo Cruz, Ministério da Saúde, 1991-01-01)
      Serine proteinase inhitors, in the seeds of several Leguminosae from the Pantanal region (West Brazil), were studied using bovine trypsin, a digestive enzyme, Factor XIIa and human plasma Kallikrein, two blood clotting ...

    • A prothrombin activator from Bothrops erythromelas (jararaca-da-seca) snake venom: characterization and molecular cloning 

      Silva, Márcia B.; Schattner, Mirta; Ramos, Celso RR; Junqueira-de-Azevedo, Inácio LM; Guarnieri, Míriam C.; Lazzari, Maria A.; Sampaio, Claudio Augusto Machado [UNIFESP]; Pozner, Roberto G.; Ventura, Janaína S.; Ho, Paulo L.; Chudzinski-Tavassi, Ana M. (Portland Press, 2003-01-01)
      A novel prothrombin activator enzyme, which we have named 'berythractivase', was isolated from Bothrops erythromelas (jararaca-da-seca) snake venom. Berythractivase was purified by a single cation-exchange-chromatography ...

    • The role of hemocytes in the immunity of the spider Acanthoscurria gomesiana 

      Fukuzawa, Aline H.; Vellutini, Bruno C.; Lorenzini, Daniel M.; Silva, Pedro I.; Mortara, Renato A. [UNIFESP]; Silva, Jose M. C. da; Daffre, Sirlei (Elsevier B.V., 2008-01-01)
      Invertebrates protect themselves against microbial infection through cellular and humoral immune defenses. Since the available information on the immune system of spiders is scarce, the main goat of the present study was ...