Browsing by Subject "cell invasion"
Now showing items 1-10 of 19
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Acidification modulates the traffic of Trypanosoma cruzi trypomastigotes in Vero cells harbouring Coxiella burnetii vacuoles
(Elsevier B.V., 2003-02-01)We studied the fate of different Trypanosoma cruzi trypomastigote forms after they invade Vero cells persistently colonised with Coxiella burnetii. When the invasion step was examined we found that persistent C. burnetii ...
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Actin-rich structures formed during the invasion of cultured cells by infective forms of Trypanosoma cruzi
(Urban & Fischer Verlag, 1999-12-01)Previous work has shown that Trypanosoma cruzi extracellular amastigotes as well as metacyclic trypomastigotes infect cultured cells in a highly specific parasite form-cell type interaction. In this work we have investigated ...
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Activation of distinct signal transduction pathways in Trypanosoma cruzi isolates with differential capacity to invade host cells
(Elsevier B.V., 2002-04-01)Mammalian cell invasion by Trypanosoma cruzi requires the activation of signal transduction pathways that result in a Ca2+ response both in the parasite and the host cell. By using drugs that interfere with the signalling ...
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Ação do inibidor de proteinase de enterolobium contortisiliquum, ecti, em células de endométrio de pacientes com endometriose
(Universidade Federal de São Paulo (UNIFESP), 2013-03-27)Endometriose é uma afecção ginecológica hormônio dependente caracterizada pela presença de tecido endometrial fora da cavidade uterina. Os eventos descritos na endometriose têm sido correlacionados com os descritos no ...
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Calcineurin B of the human protozoan parasite Trypanosoma cruzi is involved in cell invasion
(Elsevier B.V., 2008-07-01)During Trypanosoma cruzi cell invasion, signal transduction pathways are triggered in parasite and host cells, leading to a rise in intracellular Ca(2+) concentration. We posed the question whether calcineurin (CaN), in ...
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Features of host cell invasion by different infective forms of Trypanosoma cruzi
(Instituto Oswaldo Cruz, Ministério da Saúde, 1999-09-01)Through its life cycle from the insect vector to mammalian hosts Trypanosoma cruzi has developed clever strategies to reach the intracellular milieu where it grows sheltered from the hosts' immune system. We have been ...
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Interaction with host factors exacerbates Trypanosoma cruzi cell invasion capacity upon oral infection
(Elsevier B.V., 2007-12-01)Outbreaks of severe acute Chagas' disease acquired by oral infection, leading to death in some cases, have occurred in recent years. Using the mouse model, we investigated the basis of such virulence by analyzing a Trypanosoma ...
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Invasion of MDCK epithelial cells with altered expression of Rho GTPases by Trypanosoma cruzi amastigotes and metacyclic trypomastigotes of strains from the two major phylogenetic lineages
(Elsevier B.V., 2004-04-01)In order to invade mammalian cells, Trypanosoma cruzi infective forms cause distinct rearrangements of membrane and host cell cytoskeletal components. Rho GTPases have been shown to regulate three separate signal transduction ...
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Involvement of Ssp-4-related carbohydrate epitopes in mammalian cell invasion by Trypanosoma cruzi amastigotes
(Elsevier B.V., 2006-07-01)We examined whether the expression of Ssp-4-related carbohydrate epitopes defined by monoclonal antibodies ID9 and 2B7 was related to cell invasion by Trypanosonia cruzi amastigotes from different isolates and whether the ...
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Molecular basis of mammalian cell invasion by Trypanosoma cruzi
(Academia Brasileira de Ciências, 2006-03-01)Establishment of infection by Trypanosoma cruzi, the agent of Chagas' disease, depends on a series of events involving interactions of diverse parasite molecules with host components. Here we focus on the mechanisms of ...
