Now showing items 1-8 of 8

    • Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts 

      Staudt, Nicole D.; Aicher, Wilhelm K.; Kalbacher, Hubert; Stevanovic, Stefan; Carmona, Adriana Karaoglanovic [UNIFESP]; Bogyo, Matthew; Klein, Gerd (Ferrata Storti Foundation, 2010-09-01)
      Background Hematopoietic stem cells are retained within discrete bone marrow niches through the effects of cell adhesion molecules and chemokine gradients. However, a small proportion of hematopoietic stem cells can also ...

    • The disintegrin-like domain of the snake venom metalloprotease alternagin inhibits alpha 2 beta 1 integrin-mediated cell adhesion 

      Souza, DHF; Iemma, MRC; Ferreira, L. L.; Faria, J. P.; Oliva, MLV; Zingali, R. B.; Niewiarowski, S.; Selistre-de-Araujo, H. S. (Academic Press Inc, 2000-12-15)
      The alpha (2)beta (1) integrin is a major collagen receptor that plays an essential role in the adhesion of normal and tumor cells to the extracellular matrix. Here we describe the isolation of a novel metalloproteinase/ ...

    • The effect of brown spider venom on endothelial cell morphology and adhesive structures 

      Paludo, Katia Sabrina; Gremski, Luiza Helena; Veiga, Silvio Sanches; Chaim, Olga Meiri; Gremski, Waldemiro; Freitas Buchi, Dorly de; Nader, Helena Bonciani; Dietrich, Carl Peter; Franco, Celia Regina Cavichiolo [UNIFESP] (Elsevier B.V., 2006-06-15)
      Spiders of the Loxosceles genus have been responsible for severe clinical cases of envenomation worldwide. Accidents involving brown spiders can cause dermonecrotic injury, hemorrhage, hemolysis, platelet aggregation and ...

    • Extracellular enolase of Candida albicans is involved in colonization of mammalian intestinal epithelium 

      Silva, Richard C. [UNIFESP]; Padovan, Ana Carolina Barbosa [UNIFESP]; Pimenta, Daniel C.; Ferreira, Renata Carmona [UNIFESP]; Silva, Claudio Vieira da [UNIFESP]; Briones, Marcelo Ribeiro da Silva [UNIFESP] (Frontiers Research Foundation, 2014-06-01)
      Enolase is secreted by Candida albicans and is present in its biofilms although its extracellular function is unknown. Here we show that extracellular enolase mediates the colonization of small intestine mucosa by C. ...

    • A fucan from the brown seaweed Spatoglossum schröederi inhibits Chinese hamster ovary cell adhesion to several extracellular matrix proteins 

      Rocha, Hugo Alexandre Oliveira [UNIFESP]; Franco, Celia Regina Cavichlolo [UNIFESP]; Trindade, Edvaldo da Silva [UNIFESP]; Carvalho, L.c.m.; Veiga, Silvio Sanches [UNIFESP]; Leite, Edda Lisboa [UNIFESP]; Dietrich, Carl Peter [UNIFESP]; Nader, Helena Bonciani [UNIFESP] (Associação Brasileira de Divulgação Científica, 2001-05-01)
      Fucans, a family of sulfated polysaccharides present in brown seaweed, have several biological activities. Their use as drugs would offer the advantage of no potential risk of contamination with viruses or particles such ...

    • Heparan sulfate and control of cell division: adhesion and proliferation of mutant CHO-745 cells lacking xylosyl transferase 

      Franco, Celia Regina Cavichlolo [UNIFESP]; Rocha, Hugo Alexandre Oliveira [UNIFESP]; Trindade, Edvaldo da Silva [UNIFESP]; Santos, Isabel Anunciacao Neves dos [UNIFESP]; Leite, Edda Lisboa [UNIFESP]; Veiga, Silvio Sanches [UNIFESP]; Nader, Helena Bonciani [UNIFESP]; Dietrich, Carl Peter [UNIFESP] (Associação Brasileira de Divulgação Científica, 2001-08-01)
      We have examined the role of cell surface glycosaminoglycans in cell division: adhesion and proliferation of Chinese hamster ovary (CHO) cells. We used both wild-type (CHO-K1) cells and a mutant (CHO-745) which is deficient ...

    • Nitric oxide: a potential inducer of adhesion-related apoptosis-anoikis 

      Monteiro, H. P. [UNIFESP]; Silva, E. F.; Stern, A. (Elsevier B.V., 2004-02-01)
      Among the many initiating events that lead to apoptosis or programmed cell death, loss of contact between the cell and the extracellular matrix has been extensively studied. Adhesion-related apoptosis referred to as anoikis ...

    • Presence of a laminin-binding chondroitin sulfate proteoglycan at the cell surface of a human melanoma cell Mel-85 

      Elias, MCQB; Veiga, S. S.; Gremski, W.; Porcionatto, M. A.; Nader, H. B.; Brentani, R. R. (Kluwer Academic Publ, 1999-07-01)
      Working with Mel-85 (a human melanoma cell line), we have been able to detect a laminin-binding molecule with an apparent molecular mass of 100/110 kDa (Mel-85-LBM). Reduction with beta-mercaptoethanol decreases its molecular ...