Browsing by Subject "apoptosis"

Now showing items 1-10 of 91

    • Abnormal expression of MDM2 in prostate carcinoma 

      Leite, Katia Ramos Moreira [UNIFESP]; Franco, Marcello Fabiano de [UNIFESP]; Srougi, Miguel [UNIFESP]; Nesrallah, Luciano J.; Nesrallah, Adriano; Bevilacqua, Ruy G.; Darini, Elaine; Carvalho, Claudia M.; Meirelles, Maria Ines; Santana, Isaque; Camara-Lopes, L. H. (Lippincott Williams & Wilkins, 2001-05-01)
      Mutation of p53 is rare in localized prostate carcinoma the oncoprotein MDM2, whose gene has a response element for p53, promotes the degradation of p53 protein and inhibits its transcriptional activation of genes related ...

    • AC-1001 H3 CDR peptide induces apoptosis and signs of autophagy in vitro and exhibits antimetastatic activity in a syngeneic melanoma model 

      Rabaca, Aline N. [UNIFESP]; Arruda, Denise C. [UNIFESP]; Figueiredo, Carlos R. [UNIFESP]; Massaoka, Mariana H. [UNIFESP]; Farias, Camyla F. [UNIFESP]; Tada, Dayane B. [UNIFESP]; Maia, Vera C.; Silva Junior, Pedro I.; Girola, Natalia [UNIFESP]; Real, Fernando [UNIFESP]; Mortara, Renato A. [UNIFESP]; Polonelli, Luciano; Travassos, Luiz R. [UNIFESP] (Wiley, 2016)
      Antibody-derived peptides modulate functions of the immune system and are a source of anti-infective and antitumor substances. Recent studies have shown that they comprise amino acid sequences of immunoglobulin ...

    • Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease 

      Kohanim, Sahar; Palioura, Sotiria; Saeed, Hajirah N.; Akpek, Esen K.; Amescua, Guillermo; Basu, Sayan; Blomquist, Preston H.; Bouchard, Charles S.; Dart, John K.; Gai, Xiaowu; Gomes, Jose Alvaro Pereira [UNIFESP]; Gregory, Darren G.; Iyer, Geetha; Jacobs, Deborah S.; Johnson, Anthony J.; Kinoshita, Shigeru; Mantagos, Iason S.; Mehta, Jodhbir S.; Perez, Victor L.; Pflugfelder, Stephen C.; Sangwan, Virender S.; Sippel, Kimberly C.; Sotozono, Chie; Srinivasan, Bhaskar; Tan, Donald T. H.; Tandon, Radhika; Tseng, Scheffer C. G.; Ueta, Mayumi; Chodosh, James (Elsevier Science Bv, 2016)
      Our purpose is to comprehensively review the state of the art with regard to Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to improving the management of associated ocular ...

    • alpha-Tocopherol supplementation avoids apoptosis in the anal sphincter 

      Silva, Romualdo Correa da [UNIFESP]; Reis, Leonardo Oliveira; Lorenzetti, Fabio [UNIFESP]; Palma, Paulo; Ortiz, Valdemar [UNIFESP]; Dambros, Miriam [UNIFESP] (Informa Healthcare, 2012-03-01)
      Purpose: To analyze the influence of alpha-tocopherol supplementation on the levels of oxidative stress and apoptosis rates in the anal sphincter induced by orchiectomy in rats. Methods: Forty male Wistar rats weighing ...

    • Alterations in Calcium Signaling and a Decrease in Bcl-2 Expression: Possible Correlation With Apoptosis in Aged Striatum 

      Ureshino, R. P. [UNIFESP]; Bertoncini, C. R. [UNIFESP]; Fernandes, M. J. S.; Abdalla, F. M. F.; Porto, C. S. [UNIFESP]; Hsu, Y-T.; Lopes, G. S. [UNIFESP]; Smaili, Soraya Soubhi [UNIFESP] (Wiley-Blackwell, 2010-02-01)
      Aging is a multifaceted process associated with various functional and structural deficits that might be evolved in degenerative diseases. It has been shown that neurodegenerative disorders are associated with alterations ...

    • Amifostine Increases FAS and Caspase-3 Expression in Colonic Tissue of Irradiated Mice 

      Oshima, Celina Tizuko Fujiyama [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP]; Gomes, Thiago Simao [UNIFESP]; Adios, Priscila C. [UNIFESP]; Egami, Mizue Imoto [UNIFESP]; Segreto, Helena Regina Comodo [UNIFESP] (Int Inst Anticancer Research, 2015-05-01)
      Background/Aim: The aim of this study was to evaluate the expression of FASL, FAS and FADD and caspase-3 in oesophagus, stomach and colonic tissues of mice irradiated in vivo by immunohistochemistry. Materials and Methods: ...

    • Amifostine protective effect on cisplatin-treated rat testis 

      Lirdi, Leandra Campos [UNIFESP]; Stumpp, Taiza [UNIFESP]; Sasso-Cerri, Estela; Miraglia, Sandra Maria [UNIFESP] (Wiley-Blackwell, 2008-07-01)
      Cisplatin is a potent drug used in clinical oncology but causes spermatogenesis damage. Amifostine is a drug used against toxicity caused by ionizing irradiation and chemotherapeutic drugs. Since cisplatin provokes fertility ...

    • Antifungal and antitumor models of bioactive protective peptides 

      Rodrigues, Elaine Guadelupe [UNIFESP]; Dobroff, Andrey Sergee [UNIFESP]; Taborda, Carlos Pelleschi [UNIFESP]; Travassos, Luiz Rodolpho [UNIFESP] (Academia Brasileira de Ciências, 2009-09-01)
      Peptides are remarkably reactive molecules produced by a great variety of species and able to display a number of functions in uni-and multicellular organisms as mediators, agonists and regulating substances. Some of them ...

    • Apoptosis and testicular alterations in albino rats treated with etoposide during the prepubertal phase 

      Stumpp, Taiza [UNIFESP]; Sasso-Cerri, Estela [UNIFESP]; Freymüller-Haapalainen, Edna [UNIFESP]; Miraglia, Sandra Maria [UNIFESP] (Wiley-Blackwell, 2004-07-01)
      Etoposide is a podophyllotoxin semiderivative that is used in a variety of chemotherapy treatments, including therapy for children tumors. This drug promotes the formation of a ternary DNA-topoisomerase II-etoposide complex ...

    • Apoptosis in the early developing periodontium of rat molars 

      Cerri, Paulo Sergio [UNIFESP]; Freymüller-Haapalainen, Edna [UNIFESP]; Katchburian, Eduardo [UNIFESP] (Wiley-Blackwell, 2000-02-01)
      Development of the periodontium involves a series of complex steps that result in the formation of root dentine, cementum, bone and fibres of the ligament. These precisely controlled and timed events require the participation ...