Browsing by Subject "animal model"

Now showing items 1-10 of 17

    • Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice 

      Silva, R. H.; Kameda, SR; Carvalho, R. C.; Takatsu-Coleman, A. L.; Niigaki, S. T.; Abilio, V. C.; Tufik, S.; Frussa, R. (Springer, 2004-11-01)
      Rationale: Several clinical studies demonstrate that the absence of periods of sleep is closely related to occurrence of anxiety symptoms. However, the basis of these interactions is poorly understood. Studies performed ...

    • Avaliação dos mecanismos de virulência e do fitness bacteriano de isolados clínicos de Klebsiella pneumoniae produtores de KPC-2 

      Visconde, Marina Francisco [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2016-07-26)
      Objective: The aim of this study was to evaluate and compare the virulence and bacterial fitness of KPC-2-producing-K. pneumoniae isolates. Methods: A total of 30 K. pneumoniae clinical isolates distributed in three distinct ...

    • Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress 

      Girardi, Carlos Eduardo Neves [UNIFESP]; Tiba, Paula Ayako [UNIFESP]; Llobet, Gisela B. [UNIFESP]; Levin, Raquel [UNIFESP]; Abilio, Vanessa Costhek [UNIFESP]; Suchecki, Deborah [UNIFESP] (Frontiers Research Foundation, 2013-10-02)
      Traumatic stress can lead to long-term emotional alterations, which may result in Posttraumatic Stress Disorder (PTSD). Fear reactions triggered by conditioned cues and exacerbated emotional arousal in face of non-conditioned ...

    • Development of a rabbit's urethral sphincter deficiency animal model for anatomical-functional evaluation 

      Skaff, M. [UNIFESP]; Pinto, E.r.s. [UNIFESP]; Leite, Kátia Ramos Moreira [UNIFESP]; Almeida, F.g. [UNIFESP] (Sociedade Brasileira de Urologia, 2012-02-01)
      OBJECTIVE: The aim of the study was to develop a new durable animal model (using rabbits) for anatomical-functional evaluation of urethral sphincter deficiency. MATERIALS AND METHODS: A total of 40 New Zealand male rabbits, ...

    • The development of a rat model of erectile dysfunction after radical prostatectomy: preliminary findings 

      Kaufmann, Oskar [UNIFESP]; Claro, Joaquim [UNIFESP]; Cury, José [UNIFESP]; Andrade, Enrico [UNIFESP]; Longo, Beatriz [UNIFESP]; Aguiar, Wilson [UNIFESP]; Mello, Luiz [UNIFESP]; Srougi, Miguel [UNIFESP] (Wiley-Blackwell, 2008-10-01)
      To develop a rat model of erectile dysfunction (ED) after cavernous nerve injury.Given the great similarity between the anatomical structure of the cavernous nerve in rats and humans, 24 rats underwent dissections and the ...

    • Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain 

      Levin, Raquel [UNIFESP]; Peres, Fernanda Fiel [UNIFESP]; Almeida, Valeria [UNIFESP]; Calzavara, Mariana Bendlin [UNIFESP]; Zuardi, Antonio W.; Hallak, Jaime E. C.; Crippa, Jose Alexandre S.; Abilio, Vanessa Costhek [UNIFESP] (Frontiers Research Foundation, 2014-02-06)
      Clinical and neurobiological findings suggest that the cannabinoids and the endocannabinoid system may be implicated in the pathophysiology and treatment of schizophrenia. We described that the spontaneously hypertensive ...

    • Effects of reserpine on the plus-maze discriminative avoidance task: Dissociation between memory and motor impairments 

      Carvalho, Rita C.; Patti, Camilla C.; Takatsu-Coleman, Andre L.; Kameda, Sonia R.; Souza, Claudio F.; Garcez-do-Carmo, Lucia; Abilio, Vanessa C.; Fyussa-Filho, Roberto; Silva, Regina H. (Elsevier B.V., 2006-11-29)
      We investigated the effects of reserpine (0.1-0.5 mg/kg) on the performance of mice in the plus-maze discriminative avoidance task (DAVT), which simultaneously evaluates memory and motor activity. All doses induced memory ...

    • Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer 

      Resende, Wilson R.; Valvassori, Samira S.; Reus, Gislaine Z.; Varela, Roger B.; Arent, Camila O.; Ribeiro, Karine F.; Bavaresco, Daniela V.; Andersen, Monica L. [UNIFESP]; Zugno, Alexandra I.; Quevedo, Joao (Lippincott Williams & Wilkins, 2013-10-01)
      Bipolar disorder is a severe mood disorder with high morbidity and mortality. Despite adequate treatment, patients continue to have recurrent mood episodes, residual symptoms, and functional impairment. Some preclinical ...

    • A Interleucina 1-beta mostra uma ação protetora na fase aguda do modelo de epilepsia induzido pela pilocarpina 

      Pascoal, Vinícius d b; Marchesini, Rafael Breglio; Matos, Anabela hb; Conte, Fábio Frangiotti; Pereira, Tiago Campos; Gilioli, Rovilson; Malheiros, Jackeline Moraes [UNIFESP]; Polli, Roberson Saraiva [UNIFESP]; Buzzá, Hilde H; Tannús, Alberto; Covolan, Luciene [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Velloso, Lício Augusto; Cendes, Fernando; Lopes-Cendes, Íscia (Liga Brasileira de Epilepsia (LBE), 2010-09-01)
      INTRODUCTION: There is contradictory information regarding the of effects il1β and il1rn in epilepsy. We aimed to evaluate the effect of silencing both genes in the acute phase of the pilocarpine-induced epilepsy model. ...

    • Long-Term Impact of Early Life Events on Physiology and Behaviour 

      Boersma, G. J.; Bale, T. L.; Casanello, P.; Lara, H. E.; Lucion, A. B.; Suchecki, D. [UNIFESP]; Tamashiro, K. L. (Wiley-Blackwell, 2014-09-01)
      This review discusses the effects of stress and nutrition throughout development and summarises studies investigating how exposure to stress or alterations in nutrition during the pre-conception, prenatal and early postnatal ...