Browsing by Subject "Trypanosoma cruzi"
Now showing items 1-10 of 317
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1,4-Diamino-2-butanone, a putrescine analogue, promotes redox imbalance in Trypanosoma cruzi and mammalian cells
(Elsevier B.V., 2012-12-15)The putrescine analogue 1,4-diamino-2-butanone (DAB) is highly toxic to various microorganisms, including Trypanosoma cruzi. Similar to other a-aminocarbonyl metabolites. DAB exhibits pro-oxidant properties. DAB undergoes ...
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Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection
(Instituto Oswaldo Cruz, Ministério da Saúde, 2009-12-01)Trypanosoma cruzi infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the physiological network of disturbances imposed by the infection has not ...
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Acidification modulates the traffic of Trypanosoma cruzi trypomastigotes in Vero cells harbouring Coxiella burnetii vacuoles
(Elsevier B.V., 2003-02-01)We studied the fate of different Trypanosoma cruzi trypomastigote forms after they invade Vero cells persistently colonised with Coxiella burnetii. When the invasion step was examined we found that persistent C. burnetii ...
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Actin-rich structures formed during the invasion of cultured cells by infective forms of Trypanosoma cruzi
(Urban & Fischer Verlag, 1999-12-01)Previous work has shown that Trypanosoma cruzi extracellular amastigotes as well as metacyclic trypomastigotes infect cultured cells in a highly specific parasite form-cell type interaction. In this work we have investigated ...
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Activation of distinct signal transduction pathways in Trypanosoma cruzi isolates with differential capacity to invade host cells
(Elsevier B.V., 2002-04-01)Mammalian cell invasion by Trypanosoma cruzi requires the activation of signal transduction pathways that result in a Ca2+ response both in the parasite and the host cell. By using drugs that interfere with the signalling ...
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Active transcription and ultrastructural changes during Trypanosoma cruzi metacyclogenesis
(Academia Brasileira de Ciências, 2008-03-01)The differentiation of proliferating epimastigote forms of Trypanosoma cruzi , the protozoan parasite that causes Chagas disease, into the infective and non-proliferating metacyclic forms can be reproduced in the laboratory ...
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Acute Trypanosoma cruzi infection is associated with anemia, thrombocytopenia, leukopenia, and bone marrow hypoplasia: reversal by nifurtimox treatment
(Elsevier B.V., 2000-04-01)In the present work we show that acute infect-ion of C3H mice with the CL strain of Trypanosoma cruzi is characterized by an exponential growth of parasites and high mortality accompanied by anemia, thrombocytopenia, ...
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Adjuvant effect of the propionibacterium acnes and its purified soluble polysaccharide on the immunization with plasmidial DNA containing a Trypanosoma cruzi gene
(Center Academic Publ Japan, 2006-01-01)In the present work we investigated the role of killed Propionibacterium acnes or a soluble polysaccharide extracted from bacterium cell wall in modulated experimental immunization with plasmidial DNA. We used a plasmid, ...
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Alchornedine, a New Anti-Trypanosomal Guanidine Alkaloid from Alchornea glandulosa
(Georg Thieme Verlag Kg, 2014-10-01)Bioactivity-guided fractionation of the MeOH extract from the leaves of Alchornea glandulosa afforded a newguanidine alkaloid named alchornedine, as well as two other inactive derivatives (pteroginine and pteroginidine). ...
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Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases
(Elsevier B.V., 2000-06-01)The therapeutic potential of synthetic inhibitors to the major cysteine-proteinase from Trypanosoma cruzi (cruzain or cruzipain) was recently demonstrated in animal models of Chagas' disease. A possible limitation of this ...
