Browsing by Subject "Structure-activity relationships"

Now showing items 1-2 of 2

Síntese e avaliação de derivados do LINS01003 potencialmente ligantes de receptores histaminérgicos H4

Barbosa, Alefe Jhonatas Ramos [UNIFESP] (Universidade Federal de São Paulo, 2017-03-27)

Histamine is an important chemical mediator of the organism and is related to several physiological and pathological conditions, its effects produced through interactions with histaminergic G protein coupled receptors ...
A tellurium-based cathepsin B inhibitor: Molecular structure, modelling, molecular docking and biological evaluation

Caracelli, Ignez; Vega-Teijido, Mauricio; Zukerman-Schpector, Julio; Cezari, Maria H. S. [UNIFESP]; Lopes, Jose G. S.; Juliano, Luiz [UNIFESP]; Santos, Paulo S.; Comasseto, Joao V.; Cunha, Rodrigo L. O. R. [UNIFESP]; Tiekink, Edward R. T. (Elsevier B.V., 2012-04-11)

The crystallographically determined structure of biologically active 4,4-dichloro-1,3-diphenyl-4-telluraoct-2-en-1-one, 3, shows the coordination geometry for Te to be distorted psi-pentagonal bipyramidal based on a ...