Browsing by Subject "Single cell gel (comet) assay"

Now showing items 1-10 of 11

    • Are endogenous sex hormones related to DNA damage in paradoxically sleep-deprived female rats? 

      Andersen, Monica Levy [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP]; Alvarenga, Tathiana Aparecida [UNIFESP]; Silva, Andressa [UNIFESP]; Araujo, Paula [UNIFESP]; Zager, Adriano [UNIFESP]; Tenório, Neuli Maria [UNIFESP]; Tufik, Sergio [UNIFESP] (Elsevier B.V., 2010-02-01)
      The aim of this investigation was to evaluate overall DNA damage induced by experimental paradoxical sleep deprivation (PSD) in estrous-cycling and ovariectomized female rats to examine possible hormonal involvement during ...

    • Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous extract and its main purified anthocyanin (delphinidin) in vivo 

      Azevedo, Luciana; Lima, Patricia Lepage Alves de; Gomes, Jose Carlos; Stringheta, Paulo Cesar; Ribeiro, Daniel Araki [UNIFESP]; Salvadori, Daisy Maria Favero (Elsevier B.V., 2007-05-01)
      Anthocyanins are the largest group of water-soluble pigments in the plant kingdom. A number of studies have demonstrated that anthocyanins present antioxidant capacity and show inhibitory effects on the growth of some ...

    • Differential response related to genotoxicity in multiple organs of cirrhotic rats 

      Nagaoka, Márcia Regina [UNIFESP]; Le Sueur-Maluf, Luciana [UNIFESP]; Aguiar, Odair [UNIFESP]; Castro, Glaucia Monteiro de [UNIFESP]; Spadari-Bratfisch, Regina Celia [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP] (Springer, 2011-06-01)
      The aim of this study was to use the single cell gel (comet) assay to investigate whether blood, liver, heart, kidney, and brain are particularly sensitive organs for DNA damage in cirrhotic rats to predict genetic instability ...

    • Distinct effects of acute and chronic sleep loss on DNA damage in rats 

      Andersen, Monica Levy [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP]; Bergamaschi, Cassia Toledo [UNIFESP]; Alvarenga, Tathiana Aparecida [UNIFESP]; Silva, Andressa [UNIFESP]; Zager, Adriano [UNIFESP]; Campos, Ruy Ribeiro [UNIFESP]; Tufik, Sergio [UNIFESP] (Elsevier B.V., 2009-04-30)
      The aim of this investigation was to evaluate genetic damage induced in male rats by experimental sleep loss for short-term (24 and 96 h) and long-term (21 days) intervals, as well as their respective recovery periods in ...

    • DNA damage and nitric oxide synthesis in experimentally infected balb/c mice with Trypanosoma cruzi 

      Ribeiro, Daniel Araki [UNIFESP]; Calvi, Sueli A.; Picka, Mariele M.; Persi, Eliana; Carvalho, Thais B. de; Caetano, Priscila K.; Nagoshi, Lidiana R.; Lima, Carlos R. G.; Machado, Jussara Marcondes; Salvadori, Daisy Maria Favero (Elsevier B.V., 2007-07-01)
      This study aimed to evaluate whether experimental Chagas disease in acute phase under benznidazole therapy can cause DNA damage in peripheral blood, liver, heart, and spleen cells or induce nitric oxide synthesis in spleen ...

    • DNA damage in multiple organs after exposure to chlorhexidine in Wistar rats 

      Grassi, Tony Fernando; Camargo, Elaine Aparecida de; Salvadori, Daisy Maria Favero; Marques, Mariangela Esther Alencar; Ribeiro, Daniel Araki [UNIFESP] (Elsevier B.V., 2007-03-01)
      Since chlorhexidine is effective against microorganisms, it is widely recommended in dentistry. However, studies have provided evidence that chlorhexidine is toxic for a variety of cell types. in order to identify potential ...

    • Instabilidade genética induzida pelo exercício físico em múltiplos órgãos de ratos Wistar 

      Pozzi, Renan [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2010-12-01)
      O objetivo do presente estudo foi investigar danos genéticos induzidos pelo exercício agudo até a exaustão em modelo animal por meio do teste de células individualizadas em gel de agarose (teste do cometa). Ratos ...

    • Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin? 

      Kahan, Vanessa [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP]; Egydio, Flavia [UNIFESP]; Barros, L. A. [UNIFESP]; Tomimori, Jane [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica Levy [UNIFESP] (Karger, 2014-01-01)
      Skin naturally changes with age, becoming more fragile. Various stimuli can alter skin integrity. the aim of this study was to evaluate whether sleep deprivation affects the integrity of DNA in skin and exacerbates the ...

    • Lack of effect of prior treatment with fluoride on genotoxicity of two chemical agents in vitro 

      Ribeiro, Daniel Araki [UNIFESP]; Marques, Mariangela Esther Alencar; Salvadori, Daisy Maria Favero (Karger, 2007-01-01)
      The goal of this study was to investigate the ability of fluoride to modulate the genotoxic effects induced by the oxidative agent hydrogen peroxide (H2O2) and the alkylating agent methyl methanesulfonate (MMS) in vitro ...

    • Radiopacifiers do not induce genetic damage in murine fibroblasts: an in vitro study 

      Ribeiro, Daniel Araki [UNIFESP]; Carlin, Viviane [UNIFESP]; Fracalossi, Ana Carolina Cuzzuol [UNIFESP]; Oyama, Lila Missae [UNIFESP] (Wiley-Blackwell, 2009-11-01)
      P>AimTo evaluate whether several radiopacifiers are able to induce genetic damage in a laboratory cell culture study.MethodologyMurine fibroblasts were exposed to barium sulphate, bismuth oxide or zirconium oxide, at final ...