Browsing by Subject "SHR"

Now showing items 1-10 of 23

    • Abnormal proliferative response of the carotid artery of spontaneously hypertensive rats after angioplasty may be related to the depolarized state of its smooth muscle cells 

      Dalle Lucca, Shaw Lyn Dodd [UNIFESP]; Dalle Lucca, Jurandir João [UNIFESP]; Borges, Antonio Carlos Romao [UNIFESP]; Ihara, Silvia Saiuli Miki [UNIFESP]; Paiva, Therezinha B [UNIFESP] (Associação Brasileira de Divulgação Científica, 2000-08-01)
      Hypertension is one of the major precursors of atherosclerotic vascular disease, and vascular smooth muscle abnormal cell replication is a key feature of plaque formation. The present study was conducted to examine the ...

    • Antipsychotic Profile of Cannabidiol and Rimonabant in an Animal Model of Emotional Context Processing in Schizophrenia 

      Levin, Raquel [UNIFESP]; Almeida, Valeria [UNIFESP]; Peres, Fernanda Fiel [UNIFESP]; Calzavara, Mariana Bendlin [UNIFESP]; Silva, Neide Derci da [UNIFESP]; Suiama, Mayra Akimi [UNIFESP]; Niigaki, Suzy Tamie [UNIFESP]; Zuardi, Antonio Waldo [UNIFESP]; Hallak, Jaime Eduardo Cecilio; Crippa, Jose Alexandre de Souza; Abilio, Vanessa Costhek [UNIFESP] (Bentham Science Publ Ltd, 2012-11-01)
      Objectives: Clinical and neurobiological findings suggest that cannabinoids and their receptors are implicated in schizophrenia. Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa plant, has been ...

    • Blood pressure reducing effects of Phalaris canariensis in normotensive and spontaneously hypertensive rats 

      Passos, Clevia Santos [UNIFESP]; Carvalho, Lucimeire Nova [UNIFESP]; Pontes, Roberto Braz [UNIFESP]; Campos, Ruy Ribeiro [UNIFESP]; Ikuta, Olinda [UNIFESP]; Boim, Mirian Aparecida [UNIFESP] (Canadian Science Publishing, Nrc Research Press, 2012-02-01)
      The birdseed Phalaris canariensis (Pc) is popularly used as an antihypertensive agent. the aqueous extract of Pc (AEPc) was administered in adult normotensive Wistar rats and spontaneously hypertensive rats (SHR) and in ...

    • Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test 

      Almeida, Valéria de [UNIFESP]; Levin, Raquel [UNIFESP]; Peres, Fernanda Fiel [UNIFESP]; Niigaki, Suzy Tamie [UNIFESP]; Calzavara, Mariana Bendlin [UNIFESP]; Zuardi, Antonio Waldo; Hallak, Jaime Eduardo Cecilio; Crippa, José Alexandre de Souza; Abílio, Vanessa Costhek [UNIFESP] (Elsevier B.V., 2013-03-05)
      Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We have recently reported that Spontaneously ...

    • Characterization of alpha(2)-adrenoceptors in smooth muscles of the spontaneously hypertensive rat aorta 

      Fauaz, G.; Feres, T.; Farias, N. C.; Paiva, ACM; Paiva, T. B. (Elsevier B.V., 2003-02-01)
      Previous works have shown that the alpha(2)-adrenoceptor agonist UK 14,304 induced the relaxation and hyperpolarization of the rat aorta, mediated by alpha(2)-adrenoceptors present in the smooth muscles, through ...

    • The chronic blockade of angiotensin I-converting enzyme eliminates the sex differences of serum cytokine levels of spontaneously hypertensive rats 

      Dalpiaz, Polyana Lima Meireles; Lamas, Aline Zandonadi; Caliman, Izabela Facco; Medeiros, Ana Raquel Santos de; Abreu, Glaucia Rodrigues de; Moyses, Margareth Ribeiro; Andrade, Tadeu Uggere; Alves, Márcio Fernando [UNIFESP]; Carmona, Adriana Karaoglanovic [UNIFESP]; Bissoli, Nazare Souza (Assoc Bras Divulg Cientifica, 2013-02-01)
      Sex hormones modulate the action of both cytokines and the renin-angiotensin system. However, the effects of angiotensin I-converting enzyme (ACE) on the proinflammatory and anti-inflammatory cytokine levels in male and ...

    • The contextual fear conditioning deficit presented by spontaneously hypertensive rats (SHR) is not improved by mood stabilizers 

      Calzavara, Mariana Bendlin [UNIFESP]; Medrano, Wladimir Agostini [UNIFESP]; Levin, Raquel [UNIFESP]; Libanio, Tania Cristina [UNIFESP]; Ribeiro, Rosana de Alencar [UNIFESP]; Abilio, Vanessa Costhek [UNIFESP] (Elsevier B.V., 2011-08-15)
      Objectives: We have recently reported that spontaneously hypertensive rats (SHR) present a contextual fear conditioning (CFC) deficit. This deficit is improved by antipsychotic drugs, potentiated by proschizophrenia ...

    • Deficient prolylcarboxypeptidase gene and protein expression in left ventricles of spontaneously hypertensive rats (SHR) 

      Marangoni, Rossana Anderson; Santos, Rosangela Aparecida; Piccolo, Camila [UNIFESP] (Elsevier B.V., 2014-11-01)
      Prolylcarboxypeptidase (PRCP), an endothelial cell membrane serine peptidase that inactivates angiotensin II and activates pre-kallikrein, is thought to have anti-hypertensive and anti-proliferative roles in cardiovascular ...

    • Differential regulation of atrial contraction by P1 and P2 purinoceptors in normotensive and spontaneously hypertensive rats 

      Dantas Rodrigues, Juliano Quintella [UNIFESP]; Silva, Edilson Dantas da [UNIFESP]; Galvao, Kleber de Magalhaes [UNIFESP]; Miranda-Ferreira, Regiane [UNIFESP]; Caricati-Neto, Afonso [UNIFESP]; Jurkiewicz, Neide Hyppolito [UNIFESP]; Garcia, Antonio G.; Jurkiewicz, Aron [UNIFESP] (Nature Publishing Group, 2014-03-01)
      In the normotensive rat atrium, adenosine-5'-triphosphate and uridine-5'-triphosphate exert a biphasic effect consisting of an initial negative inotropic effect (NIE) followed by a subsequent positive inotropic effect ...

    • Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats 

      Calzavara, Mariana Bendlin [UNIFESP]; Levin, Raquel [UNIFESP]; Medrano, Wladimir Agostini [UNIFESP]; Almeida, Valeria [UNIFESP]; Frois Sampaio, Antonio Pereira [UNIFESP]; Barone, Lucas Cerqueira [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]; Abilio, Vanessa Costhek [UNIFESP] (Elsevier B.V., 2011-11-20)
      We have recently reported that spontaneously hypertensive rats (SHRs) exhibit a deficit in contextual fear conditioning that is specifically reversed by antipsychotic and potentiated by psychostimulants and other manipulations ...