Browsing by Subject "Rho GTPases"
Now showing items 1-4 of 4
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Caracterização dos efeitos celulares e moleculares de EHT- 1864, um inibidor de RAC, em células de leucemia mieloide aguda
(Universidade Federal de São Paulo (UNIFESP), 2021)Acute myeloid leukemia (AML) is a hematological neoplasm caused by molecular changes in the hematopoietic stem- and progenitor cells, leading to the accumulation of undifferentiated myeloid cells with higher proliferation ...
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Invasion of MDCK epithelial cells with altered expression of Rho GTPases by Trypanosoma cruzi amastigotes and metacyclic trypomastigotes of strains from the two major phylogenetic lineages
(Elsevier B.V., 2004-04-01)In order to invade mammalian cells, Trypanosoma cruzi infective forms cause distinct rearrangements of membrane and host cell cytoskeletal components. Rho GTPases have been shown to regulate three separate signal transduction ...
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Investigação dos efeitos do silenciamento das proteínas RhoA e RhoC na proliferação clonal de linhagens mieloides
(Universidade Federal de São Paulo, 2023-11-24)A leucemia mieloide aguda (LMA) é um câncer de medula óssea altamente heterogêneo, caracterizado por desregulação bioquímica resultante de alterações moleculares em células-tronco e progenitoras do sistema hematopoiético. ...
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Rac1/WAVE2 and Cdc42/N-WASP Participation in Actin-Dependent Host Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi
(Frontiers Media Sa, 2018)This study evaluated the participation of host cell Rho-family GTPases and their effector proteins in the actin-dependent invasion by Trypanosoma cruzi extracellular amastigotes (EAs). We observed that all proteins were ...
