Browsing by Subject "RNA interference"
Now showing items 1-8 of 8
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Brasiliensin: A novel intestinal thrombin inhibitor from Triatoma brasiliensis (Hemiptera : Reduviidae) with an important role in blood intake
(Elsevier B.V., 2007-10-01)Every hematophagous invertebrate studied to date produces at least one inhibitor of coagulation. Among these, thrombin inhibitors have most frequently been isolated. in order to study the thrombin inhibitor from Triatoma ...
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Influence of the intestinal anticoagulant in the feeding performance of triatomine bugs (Hemiptera; Reduviidae)
(Elsevier B.V., 2011-06-01)Triatomines are haematophagous insects in all post-embryonic life stages. They are vectors of Ttypanosoma cruzi, the causative agent of Chagas disease. Their vectorial ability is influenced by their feeding performance, ...
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Oxidative stress protection of Trypanosomes requires selenophosphate synthase
(Elsevier B.V., 2011-11-01)Selenoproteins are characterized by the incorporation of at least one amino acid selenocysteine (Sec-U) encoded by in-frame UGA stop codons. These proteins, as well as the components of the Sec synthesis pathway, are present ...
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Regulation of neurogenesis and gliogenesis of retinoic acid-induced P19 embryonal carcinoma cells by P2X2 and P2X7 receptors studied by RNA interference
(Elsevier B.V., 2012-04-01)Embryonic carcinoma cells are widely used models for studying the mechanisms of proliferation and differentiation occurring during early embryogenesis. We have now investigated how down-regulation of P2X2 and P2X7 receptor ...
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RNA Interference: a Promising Therapy for Gastric Cancer
(Asian Pacific Organization Cancer Prevention, 2014-01-01)Gastric cancer (GC) remains a virtually incurable disease when metastatic and requires early screening tools for detection of early tumor stages. Therefore, finding effective strategies for prevention or recurrence of GC ...
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The Shwachman-Bodian-Diamond syndrome associated protein interacts with HsNip7 and its down-regulation affects gene expression at the transcriptional and translational levels
(Elsevier B.V., 2007-12-10)The Shwachman-Bodian-Diamond syndrome (SDS) is an autosomal disorder with pleiotropic phenotypes including pancreatic, skeletal and bone marrow deficiencies and predisposition to hematological dysfunctions. SDS has been ...
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Silencing of P2X7R by RNA interference in the hippocampus can attenuate morphological and behavioral impact of pilocarpine-induced epilepsy
(Springer, 2017)Cell signaling mediated by P2X7 receptors (P2X7R) has been suggested to be involved in epileptogenesis, via modulation of intracellular calcium levels, excitotoxicity, activation of inflammatory cascades, and cell death, ...
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O uso de interferência por RNA para a análise da função do gene E2F1 na progressão do ciclo celular em células tumorais
(Universidade Federal de São Paulo (UNIFESP), 2010-10-27)E2F1 belongs to a family of transcription factors and plays a central role in controlling the expression of genes related to regulation of the cell-cycle progression, since it activates genes involved in DNA synthesis. The ...
