Now showing items 1-7 of 7

    • Analysis of somatic mutations in BRAF, CDKN2A/p16 and PI3KCA in patients with medullary thyroid carcinoma 

      Nascimento, Fabricio P. [UNIFESP]; Cardoso, Mirian G. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Kunii, Ilda S. [UNIFESP]; Valente, Flavia O. F. [UNIFESP]; Kizys, Marina M. L. [UNIFESP]; Delcelo, Rosana [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Dias-da-Silva, Magnus R. [UNIFESP] (Spandidos Publ Ltd, 2016)
      Medullary thyroid carcinoma (MTC), a neuroendocrine tumor originating from thyroid parafollicular cells, has been demonstrated to be associated with mutations in RET, HRAS, KRAS and NRAS. However, the role of other genes ...

    • Analysis of somatic mutations in BRAF, CDKN2A/p16 and PI3KCA in patients with medullary thyroid carcinoma 

      Nascimento, Fabricio P. [UNIFESP]; Cardoso, Mirian G. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Kunii, Ilda S. [UNIFESP]; Valente, Flavia O. F. [UNIFESP]; Kizys, Marina M. L. [UNIFESP]; Delcelo, Rosana [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Dias-da-Silva, Magnus R. [UNIFESP] (Spandidos Publ Ltd, 2016)
      Medullary thyroid carcinoma (MTC), a neuroendocrine tumor originating from thyroid parafollicular cells, has been demonstrated to be associated with mutations in RET, HRAS, KRAS and NRAS. However, the role of other genes ...

    • Avaliar o efeito do receptor P2X 7 no sistema renina- angiotensina durante a progressão da nefropatia diabética 

      Nascimento, Moises [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2020-01-30)
      Aim: To analyze the effect of P2X7 receptor on RAS in DN. Methods: Uninephectomized male Wistar rats received a single dose of streptozotocin (60 mg/kg, i.v) for diabetes mellitus (DM) induction; control animals (CTL) ...

    • Hemodynamic, morphometric and autonomic patterns in hypertensive rats - renin-angiotensin system modulation 

      Zamo, Fernanda de Souza [UNIFESP]; Lacchini, Silvia; Mostarda, Cristiano [UNIFESP]; Chiavegatto, Silvana; Moraes-Silva, Ivana Cinthya [UNIFESP]; Oliveira, Edilamar Menezes de; Irigoyen, Maria Claudia [UNIFESP] (Faculdade de Medicina / USP, 2010-01-01)
      BACKGROUND: Spontaneously hypertensive rats develop left ventricular hypertrophy, increased blood pressure and blood pressure variability, which are important determinants of heart damage, like the activation of renin-angiotensin ...

    • Identificação de eventos genéticos que cooperam com RAS ou PAX8/PPARG na gênese do carcinoma da tiroide 

      Carneiro, Thaise Nayane Ribeiro [UNIFESP] (Universidade Federal de São Paulo, 2021)
      O câncer de tiroide é a neoplasia maligna mais comum do sistema endócrino. Dentre as alterações genéticas identificadas nos tumores da tiroide, encontram-se as mutações pontuais no gene RAS e a fusão PAX8-PPARG. Tais ...

    • Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats 

      Santos, Edson Lucas; Souza, Kely de Picoli; Silva, Elton Dias da [UNIFESP]; Batista, Elice Carneiro [UNIFESP]; Forcina Martins, Paulo J. [UNIFESP]; D'Almeida, Vania [UNIFESP]; Pesquero, Joao Bosco [UNIFESP] (Elsevier B.V., 2009-10-15)
      Renin-angiotensin system is involved in homeostasis processes linked to renal and cardiovascular system and recently has been linked to metabolic syndrome. We analyzed the influence of long term angiotensin I converting ...

    • Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: Overlapping clinical manifestations with Costello syndrome 

      Narumi, Yoko; Aoki, Yoko; Niihori, Tetsuya; Neri, Giovanni; Cave, Helene; Verloes, Alain; Nava, Caroline; Kavamura, Maria Ines; Okamoto, Nobuhiko; Kurosawa, Kenji; Hennekam, Raoul C. M.; Wilson, Louise C.; Gillessen-Kaesbach, Gabriele; Wieczorek, Dagmar; Lapunzina, Pablo; Ohashi, Hirofumi; Makita, Yoshio; Kondo, Ikuko; Tsuchiya, Shigeru; Ito, Etsuro; Sameshima, Kiyoko; Kato, Kumi; Kure, Shigeo; Matsubara, Yokhi (Wiley-Blackwell, 2007-04-15)
      Cardio-facio-cutaneous (CFC) syndrome is a multiple congenital anomaly/mental retardation syndrome characterized by heart defects, a distinctive facial appearance, ectodermal abnormalities and mental retardation. Clinically, ...