Browsing by Subject "Protease inhibitors"
Now showing items 1-8 of 8
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Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7
(Elsevier B.V., 2011-10-15)Human kallikrein 5 and 7 (KLK5 and KLK7) are trypsin-like and chymotrypsin-like serine proteases, respectively, and promising targets for the treatment of skin desquamation, inflammation and cancer. in an effort to develop ...
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Caracterização, clonagem e expressão de um inibidor de elástase de neutrófilo humano, purificado de sementes de Caesalpinia echinata (pau-brasil)
(Universidade Federal de São Paulo (UNIFESP), 2006-12-31)As proteases são enzimas que participam de diversos processos biológicos, como a liberação de peptídeos biologicamente ativos, a coagulação sangüínea, a fibrinólise e a cascata do complemento, mas também de processos ...
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Differential transcript profile of inhibitors with potential anti-venom role in the liver of juvenile and adult Bothrops jararaca snake
(Peerj Inc, 2017)Background. Snakes belonging to the Bothrops genus are vastly distributed in Central and South America and are responsible for most cases of reported snake bites in Latin America. The clinical manifestations of the ...
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Effectiveness and safety of first-generation protease inhibitors in real-world patients with hepatitis C virus genotype 1 infection in Brazil: a multicenter study
(Hospital Clinicas, Univ Sao Paulo, 2017)OBJECTIVE: To evaluate the effectiveness and safety of first-generation protease inhibitors for the treatment of genotype 1 hepatitis C virus-infected patients at Brazilian reference centers. METHODS: This multicenter ...
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Foot and mouth disease leader protease (Lb(pro)): Investigation of prime side specificity allows the synthesis of a potent inhibitor
(Elsevier B.V., 2012-03-01)Foot and mouth disease virus expresses its genetic information as a single polyprotein that is translated from the single-stranded RNA genome. Proteinases contained within the polyprotein then generate the mature viral ...
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Isolamento e caracterização preliminar de inibidores de proteinases de enterolobium contortisiliquum, torresea cearnsis, bauhinia petandra e bauhinia bauhinioides
(Universidade Federal de São Paulo (UNIFESP), 1988) -
Prevalência de variantes associadas à resistência aos inibidores de protease em hemodialisados e transplantados renais com infecção pelo virus da hepatite C
(Universidade Federal de São Paulo (UNIFESP), 2016-08-30)NS3 protease inhibitors (PIs) were the first direct antiviral agents (DAAs) for the treatment of hepatitis C virus. The combination of second-wave PIs with other DAAs permitted the use of interferon-free regimens for chronic ...
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Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema
(Elsevier B.V., 2013-12-01)Acute lung injury (ALI) is characterized by neutrophil infiltration and the release of proteases, mainly elastase (NE), cathepsin G (Cat G) and proteinase 3 (PR3), which can be controlled by specific endogenous inhibitors. ...
