Now showing items 1-10 of 18

    • Analysis of the ki-67 index in the vaginal epithelium of castrated rats treated with tamoxifen 

      Nery-Aguiar, Afif Rieth; Aguiar, Yousef Qathaf; Conde Junior, Airton Mendes; Alencar, Airlane Pereira; Tavares, Cleciton Braga; Lopes-Costa, Pedro Vitor; Nazario, Afonso Celso [UNIFESP]; da Silva, Benedito Borges (Hospital clinicas, univ sao paulo, 2016)
      OBJECTIVES: Vaginal atrophy and breast cancer are common conditions in postmenopausal women and tamoxifen is the standard endocrine treatment for hormone-sensitive tumors. The present study aimed to assess the effect of ...

    • ANKHD1 regulates cell cycle progression and proliferation in multiple myeloma cells 

      Dhyani, Anamika; Duarte, Adriana S. S.; Machado-Neto, Joao A.; Favaro, Patricia [UNIFESP]; Ortega, Manoela Marques; Saad, Sara T. Olalla (Elsevier B.V., 2012-12-14)
      ANKHD1 is a multiple ankyrin repeat containing protein, highly expressed in cancers, such as acute leukemia. the present study was undertaken to determine the expression and functional significance of ANKHD1 in human ...

    • Bauhinia bauhinioides cruzipain inhibitor reduces endothelial proliferation and induces an increase of the intracellular Ca2+ concentration 

      Bilgin, Mehmet; Neuhof, Christiane; Doerr, Oliver; Benscheid, Utz; Andrade, Sheila S. [UNIFESP]; Most, Astrid; Abdallah, Yaser; Parahuleva, Mariana; Guenduez, Dursun; Oliva, Maria L. [UNIFESP]; Erdogan, Ali (Servicio Publicaciones Universidad Navarra, 2010-12-01)
      Proteinase inhibitors, isolated from different types of Bauhinia, have an effect on apoptosis, angiogenesis and inflammation. the Bauhinia bauhinioides cruzipain inhibitor (BbCI) is a Kunitz-type inhibitor and inactivates ...

    • Blockage of Wnt/beta-catenin signaling by quercetin reduces survival and proliferation of B-1 cells in vitro 

      Tavares Novo, Marilia Campos [UNIFESP]; Osugui, Lika [UNIFESP]; Reis, Vanessa Oliveira dos [UNIFESP]; Longo-Maugeri, Ieda Maria [UNIFESP]; Mariano, Mario [UNIFESP]; Popi, Ana Flavia [UNIFESP] (Elsevier B.V., 2015-01-01)
      The Wnt/beta-catenin signaling pathway has been shown to play an important role in controlling the proliferation, survival and differentiation of hematopoietic cells. Several Wnt/beta-catenin signaling components influence ...

    • Effect of bauhinia bauhinioides kallikrein inhibitor on endothelial proliferation and intracellular calcium concentration 

      Bilgin, M.; Burgazli, K. M.; Rafiq, A.; Mericliler, M.; Neuhof, C.; Oliva, M. L. [UNIFESP]; Parahuleva, M.; Soydan, N.; Doerr, O.; Abdallah, Y.; Erdogan, A. (Verduci Publisher, 2014-01-01)
      OBJECTIVES: Proteinase inhibitors act as a defensive system against predators e.g. insects, in plants. Bauhinia bauhinioides kallikrein inhibitor (BbKI) is a serine proteinase inhibitor, isolated from seeds of Bauhinia ...

    • Immunohistochemical analysis of pdgfr-alpha, pdgfr-beta and c-abl in retinoblastoma: potential therapeutic targets 

      Sanft, Debra-Meghan; Worme, Mali Dawn; de Moura, Leticia Rielo [UNIFESP]; Zoroquiain, Pablo; Fernandes, Bruno F.; Antecka, Emilia; Burnier, Miguel N., Jr. (Karger, 2016)
      Background: Our laboratory previously reported that imatinib mesylate (IM) has an inhibitory effect on two retinoblastoma (Rb) cell lines in vitro. Aims: The purpose of this project was to determine the immunoexpression ...

    • Impact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavior 

      Takada, Silvia Honda; Motta-Teixeira, Livia Clemente; Machado-Nils, Aline Vilar; Lee, Vitor Yonamine; Sampaio, Carlos Alberto; Polli, Roberson Saraiva [UNIFESP]; Malheiros, Jackeline Moraes [UNIFESP]; Takase, Luiz Fernando; Kihara, Alexandre Hiroaki; Covolan, Luciene [UNIFESP]; Xavier, Gilberto Fernando; Nogueira, Maria Ines (Elsevier Science Bv, 2016)
      Neonates that suffer oxygen deprivation during birth can have long lasting cognitive deficits, such as memory and learning impairments. Hippocampus, one of the main structures that participate in memory and learning ...

    • Impact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavior 

      Takada, Silvia Honda; Motta-Teixeira, Livia Clemente; Machado-Nils, Aline Vilar; Lee, Vitor Yonamine; Sampaio, Carlos Alberto; Polli, Roberson Saraiva [UNIFESP]; Malheiros, Jackeline Moraes [UNIFESP]; Takase, Luiz Fernando; Kihara, Alexandre Hiroaki; Covolan, Luciene [UNIFESP]; Xavier, Gilberto Fernando; Nogueira, Maria Ines (Elsevier Science Bv, 2016)
      Neonates that suffer oxygen deprivation during birth can have long lasting cognitive deficits, such as memory and learning impairments. Hippocampus, one of the main structures that participate in memory and learning ...

    • Intracellular signaling pathways involved in the relaxin-induced proliferation of rat Sertoli cells 

      Nascimento, Aline Rosa [UNIFESP]; Pimenta, Maristela Taliari [UNIFESP]; Lucas, Thais Fabiana Gameiro [UNIFESP]; Royer, Carine [UNIFESP]; Porto, Catarina Segreti [UNIFESP]; Lazari, Maria de Fatima Magalhaes [UNIFESP] (Elsevier B.V., 2012-09-15)
      Regulation of Sertoli cell number is a key event to determine normal spermatogenesis. We have previously shown that relaxin and its G-protein coupled receptor RXFP1 are expressed in rat Sertoli cells, and that relaxin ...

    • Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells 

      Machado-Neto, Joao Agostinho; Favaro, Patricia [UNIFESP]; Lazarini, Mariana; Costa, Fernando Ferreira; Saad, Sara Teresinha Olalla; Traina, Fabiola (Elsevier B.V., 2011-08-01)
      BCR-ABL kinase activates downstream signaling pathways, including the PI3K-Akt/mTOR and the MAPK pathway. IRS1 has been previously described as constitutively phosphorylated and associated with BCR-ABL in K562 cells, ...