Browsing by Subject "Pilocarpine"

The A(1) receptor agonist R-Pia reduces the imbalance between cerebral glucose metabolism and blood flow during status epilepticus: Could this mechanism be involved with neuroprotection?

Silva, Lara Ribeiro [UNIFESP]; Nehlig, Astrid; Rosim, Fernanda Elisa [UNIFESP]; Vignoli, Thiago [UNIFESP]; Persike, Daniele Suzete [UNIFESP]; Ferrandon, Arielle; Sinigaglia-Coimbra, Rita [UNIFESP]; Silva Fernandes, Maria Jose da [UNIFESP] (Elsevier B.V., 2011-01-01)

It is well known that the uncoupling between local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF), i.e. decrease in LCBF rates with high LCGU, is frequently associated with seizure-induced neuronal ...

Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life

Ferreira, B.l.c. [UNIFESP]; Valle, A.c.; Cavalheiro, Esper Abrão [UNIFESP]; Timo-iaria, C. (Associação Brasileira de Divulgação Científica, 2003-12-01)

Administration of pilocarpine causes epilepsy in rats if status epilepticus (SE) is induced at an early age. To determine in detail the electrophysiological patterns of the epileptogenic activity in these animals, 46 Wistar ...

Activation and involvement of the lateral-posterior nucleus of the thalamus after a single generalized tonic-clonic seizure

Sonoda, Eliza Yumi de Freitas [UNIFESP]; Cysneiros, Roberta Monterazzo; Arida, Ricardo Mario [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP] (Elsevier B.V., 2013-07-01)

The lateral-posterior thalamic nuclei (LP) have been shown to play an important role in controlling epileptic activity. in addition, thalamic atrophy and neuronal loss have been observed in epilepsy. the objective of this ...

Adenosina e neuroproteção na epilepsia do lobo temporal: da ativação do receptor A1 ao bloqueio do receptor A2A

Rosim, Fernanda Elisa [UNIFESP]; Silva, Iara Ribeiro [UNIFESP]; Persike, Daniele Suzete [UNIFESP]; Vignoli, Thiago [UNIFESP]; Fernandes, Maria Jose da Silva [UNIFESP] (Liga Brasileira de Epilepsia (LBE), 2010-01-01)

OBJECTIVE: To characterize the effect of the A2A receptor blockage by the SCH58261 in the seizure modulation and neuroprotection of the brain areas vulnerable to injury by pilocarpine. The effect of SCH58261 was also ...

Alterações neuroquímicas associadas a epilepsia do lobo temporal

Naffah-Mazzacoratti, Maria da Graca [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2003)

O modelo de epilepsia induzido pela injecao sistemica de pilocarpina, um agonista colinergico muscarinico, reproduz em roedores as principais caracteristicas da epilepsia do lobo temporal, que acomete os seres humanos e, ...

Alterações plásticas da epileptogênese com ênfase na reorganização colinérgica

Pereira, Heloisa Aparecida Alves [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2006-01-01)

Purpose: We investigated whether the administration of scopolamine, has the ability to interfere in the epileptogenic process and whether this effect could be explained by plastic changes in the cholinergic system. Methods: ...

Alteration of purinergic P2X(4) and P2X(7) receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine

Doná, Flávia [UNIFESP]; Ulrich, Henning; Persike, Daniele Suzete [UNIFESP]; Conceição, Isaltino Marcelo da [UNIFESP]; Blini, João Paulo [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Silva Fernandes, Maria Jose [UNIFESP] (Elsevier B.V., 2009-02-01)

Although ATP and P2X receptor activity have been lately associated with epilepsy, little is known regarding their exact roles in epileptogenesis. Temporal-lobe epilepsy (TLE) in rat was induced by pilocarpine in order to ...