Browsing by Subject "Pharmacoresistance"

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Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment

Pontes, Josy Carolina Covan [UNIFESP]; Lima, Thiago Z.; Queiroz, Claudio M.; Cinini, Simone Maria [UNIFESP]; Blanco, Miriam Marcela [UNIFESP]; Mello, Luiz Eugenio Araujo de Moraes [UNIFESP] (Elsevier Science Bv, 2016)

The efficiency of most of the new antiepileptic drugs (AEDs) on clinical trials still falls short the success reported in pre-clinical studies, possibly because the validity of the animal models is insufficient to fully ...