Now showing items 1-10 of 12

    • Angiogenesis and growth factor modulation induced by altelnagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound model 

      Correia St Ana, Estela Maria; Cacao Paiva Gouvea, Cibele Marli; Nakaie, Clovis Ryuichi [UNIFESP]; Selistre-de-Araujo, Heloisa Sobreiro (Elsevier B.V., 2008-11-01)
      In this work, we show that alternagin-C (ALT-C) and ALT-C PEP, a peptide derived from its sequence, were able to induce angiogenesis ill Wounded rat skin. A spherical Cutaneous excision was made in the back of each animal ...

    • Anti-tumor activities of peptides corresponding to conserved complementary determining regions from different immunoglobulins 

      Figueiredo, Carlos R. [UNIFESP]; Matsuo, Alisson L. [UNIFESP]; Massaoka, Mariana H. [UNIFESP]; Polonelli, Luciano; Travassos, Luiz R. [UNIFESP] (Elsevier B.V., 2014-09-01)
      Short synthetic peptides corresponding to sequences of complementarity-determining regions (CDRs) from different immunoglobulin families have been shown to induce antimicrobial, antiviral and antitumor activities regardless ...

    • Comparative fibril formation of analogs corresponding to the (12-24) segment of the beta-amyloid peptide 

      Malavolta, Luciana; Nakaie, Clovis R. [UNIFESP] (Springer, 2011-12-01)
      The (1-42) beta-amyloid peptide is a main component of the plaques found in the brain of patients suffering from the Alzheimer's disease. As the single substitution of Glu for Gln at position 22 of this peptide seems to ...

    • Efeito Do Peptídeo Ligante De Heparam Sulfato Na Progressão Tumoral 

      Melo, Carina Mucciolo [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2018-02-22)
      Effect Of Heparan Sulfate-Binding Peptide In Tumor Progression Heparan Sulfate (Hs) Is Widely Distributed And Evolutionarily Conserved, A Fact That Dates Back To The Vital Importance Of This Molecule In Cell Development ...

    • Effect of gamma radiation on the structural and biological properties of Angiotensin II 

      Nardi, Daniela Teves [UNIFESP]; Casare, Murilo S.; Teixeira, Luis G. D. [UNIFESP]; Nascimento, Nanci; Nakaie, Clovis Ryuichi [UNIFESP] (Taylor & Francis Ltd, 2008-01-01)
      Purpose: the vasoactive octapeptide hormone angiotensin II (DRVYIHPF, AngII) was selected as the target of this2investigation, which was aimed at determining the effect of gamma radiation on peptide structure and biological ...

    • Gamma Ray Irradiation of the Vasoactive Peptide Bradykinin Reveals a Residue- and Position-Dependent Structural Modification 

      Nardi, Daniela T. [UNIFESP]; Rosa, Jose C.; Jubilut, Guita N. [UNIFESP]; Miranda, Antonio [UNIFESP]; Nascimento, Nanci; Nakaie, Clovis R. [UNIFESP] (Springer, 2010-06-01)
      In this work the effect of radical species generated by gamma ray irradiation of aqueous solution upon structure of vasoactive peptide bradykinin (BK, RPPGFSPFR) was investigated. Increasing doses of 1-15 kGy Co-60 gamma ...

    • The interaction of an antiparasitic peptide active against African Sleeping Sickness with cell membrane models 

      Pascholati, Caue P.; Lopera, Esteban Parra; Pavinatto, Felippe J.; Caseli, Luciano [UNIFESP]; Nobre, Thatyane M.; Zaniquelli, Maria E. D.; Viitala, Tapani; D'Silva, Claudius; Oliveira, Osvaldo N. (Elsevier B.V., 2009-12-01)
      Zwitterionic peptides with trypanocidal activity are promising lead compounds for the treatment of African Sleeping Sickness, and have motivated research into the design of compounds capable of disrupting the protozoan ...

    • Leishmania (Viannia) braziliensis nucleoside triphosphate diphosphohydrolase (NTPDase 1): Localization and in vitro inhibition of promastigotes growth by polyclonal antibodies 

      Porcino, Gabriane Nascimento; Carvalho-Campos, Cristiane; Ribeiro Gomes Maia, Ana Carolina; Detoni, Michelle Lima; Faria-Pinto, Priscila; Coimbra, Elaine Soares; Marques, Marcos Jose; Juliano, Maria Aparecida [UNIFESP]; Juliano, Luiz [UNIFESP]; Diniz, Vanessa Alvaro; Corte-Real, Suzana; Vasconcelos, Eveline Gomes (Elsevier B.V., 2012-10-01)
      Nucleoside triphosphate diphosphohydrolase (NTPDase) activity was recently characterized in Leishmania (Viannia) braziliensis promastigotes (Lb), and an antigenic conserved domain (r82-121) from the specific NTPDase 1 ...

    • Physicochemical and chromatographic evaluation of benzhydrylamine-resin as an anion exchanger solid support 

      Carvalho, Regina Siqueira Haddad [UNIFESP]; Nakaie, Clovis Ryuichi [UNIFESP]; Silva, Elias Horacio da [UNIFESP]; Santos, Isabel Anunciacao Neves dos [UNIFESP]; Dietrich, Carl Peter von [UNIFESP]; Nader, Helena Bonciani [UNIFESP]; Tersariol, Ivarne Luis dos Santos [UNIFESP] (Elsevier B.V., 2003-07-31)
      Benzhydrylamine-resin (BHAR), a copolymer of styrene-divinylbenzene containing phenylmethylamine groups, used as solid support for peptide synthesis, was examined regarding physicochemical and anion exchanger chromatographic ...

    • Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors 

      Qvit, Nir; Schechtman, Deborah; Pena, Darlene Aparecida; Berti, Denise Aparecida; Soares, Chrislaine Oliveira; Miao, Qianqian; Liang, Liying (Annie); Baron, Lauren A.; Teh-Poot, Christian; Martinez-Vega, Pedro; Ramirez-Sierra, Maria Jesus; Churchill, Eric; Cunningham, Anna D.; Malkovskiy, Andrey V.; Federspiel, Nancy A.; Gozzo, Fabio Cesar; Torrecilhas, Ana Claudia [UNIFESP]; Manso Alves, Maria Julia; Jardim, Armando; Momar, Ndao; Dumonteil, Eric; Mochly-Rosen, Daria (Elsevier Sci Ltd, 2016)
      Parasitic diseases cause similar to 500,000 deaths annually and remain a major challenge for therapeutic development. Using a rational design based approach, we developed peptide inhibitors with anti-parasitic activity ...