Browsing by Subject "Pancreatic islets"

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L-Arginine supplementation improves insulin sensitivity and beta cell function in the offspring of diabetic rats through AKT and PDX-1 activation

Carvalho, Diego Soares [UNIFESP]; Diniz, Marilia Melo [UNIFESP]; Haidar, Andre Abour [UNIFESP]; Cavanal, Maria de Fatima [UNIFESP]; Alves, Eduardo da Silva [UNIFESP]; Carpinelli, Angelo Rafael; Gil, Frida Zaladek [UNIFESP]; Hirata, Aparecida Emiko [UNIFESP] (Elsevier Science Bv, 2016)

Maternal hyperglycemia can result in defects in glucose metabolism and pancreatic beta-cell function in offspring. The purpose of this study was to evaluate the impact of maternal diabetes mellitus on pancreatic islets, ...
Secreção de insulina, sinalização de Ca2+ e função mitocondrial em ilhotas de ratas senescentes

Coelho, Fernanda Monteiro [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2010-08-25)

Aging is associated with changes in pancreatic β cells sensitivity to nutrients resulting in glucose intolerance and diabetes mellitus (DM) type 2 (DM 2) development. Here the study cells function Ca2+ signaling, mitochondrial ...