Now showing items 1-3 of 3

    • Activation of P2Y(1) receptor triggers two calcium signaling pathways in bone marrow erythroblasts 

      Paredes-Gamero, E. J.; Craveiro, R. B.; Pesquero, J. B.; Franca, J. P.; Oshiro, MEM; Ferreira, A. T. (Elsevier B.V., 2006-03-18)
      In this study, we describe the presence of P2 receptor subtypes and Ca2+ signaling in erythroblasts. ATP and ADP produced a biphasic increase of intracellular Ca2+ concentration ([Ca2+],), with an initial transient phase ...

    • Phosphoproteome Reveals an Atlas of Protein Signaling Networks During Osteoblast Adhesion 

      Milani, Renato; Ferreira, Carmen V.; Granjeiro, Jose M.; Paredes-Gamero, Edgar J. [UNIFESP]; Silva, Rodrigo A.; Justo, Giselle Z. [UNIFESP]; Nader, Helena B. [UNIFESP]; Galembeck, Eduardo; Peppelenbosch, Maikel P.; Aoyama, Hiroshi; Zambuzzi, Willian F. (Wiley-Blackwell, 2010-04-01)
      Cell adhesion on surfaces is a fundamental process in the emerging biomaterials field and developmental events as well. However, the mechanisms regulating this biological process in osteoblasts are not fully understood. ...

    • Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma 

      Toricelli, Mariana [UNIFESP]; Melo, Fabiana H. M. [UNIFESP]; Hunger, Aline; Zanatta, Daniela; Strauss, Bryan E.; Jasiulionis, Miriam G. [UNIFESP] (Mdpi Ag, 2017)
      High TIMP1 expression is associated with poor prognosis in melanoma, where it can bind to CD63 and beta 1 integrin, inducing PI3-kinase pathway and cell survival. Phosphatidylinositol (3,4,5)-trisphosphate (PIP3), generated ...