Browsing by Subject "PHEX"

Now showing items 1-4 of 4

    • Estudo da ação da osteopontina na inibição da expressão genica do cotransportador de sódio-fosfato NPT2A 

      Chiarantin, Gabrielly Maria Denadai [UNIFESP] (Universidade Federal de São Paulo, 2014-03-26)
      The X-linked hypophosphatemia (XLH) is the most prevalent form of inherited rickets in humans, occurring as a consequence of inactivating mutations in the PHEX gene (phosphate-regulating gene with homologies to endopeptidases ...

    • Estudo do envolvimento da metalo-peptidase PHEX em processos tumorais 

      Neves, Raquel Leão [UNIFESP] (Universidade Federal de São Paulo, 2013-03-28)
      A PHEX é uma metalo-peptidase codificada pelo gene PHEX (phosphate-regulating gene with homologies to endopeptidase on the X chromosome), identificado em 1995 como sendo o gene mutado em pacientes com uma forma prevalente ...

    • Expression and inactivation of osteopontin-degrading PHEX enzyme in squamous cell carcinoma 

      Neves, Raquel L. [UNIFESP]; Chiarantin, Gabrielly M. D. [UNIFESP]; Nascimento, Fabio D.; Pesquero, Joao B. [UNIFESP]; Nader, Helena B. [UNIFESP]; Tersariol, Ivarne L. S. [UNIFESP]; McKee, Marc D.; Carmona, Adriana K. [UNIFESP]; Barros, Nilana M. T. [UNIFESP] (Pergamon-Elsevier Science Ltd, 2016)
      Proteolytic enzymes mediate the activation or inactivation of many physiologic and pathologic processes. The PHEX gene (Phosphate-regulating gene with homologies to endopeptidase on the X chromosome) encodes a metallopeptidase, ...

    • Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia 

      Barros, Nilana Meza Tenório de [UNIFESP]; Hoac, Betty; Neves, Raquel Leão [UNIFESP]; Addison, William N.; Assis, Diego Magno [UNIFESP]; Murshed, Monzur; Carmona, Adriana Karaoglanovic [UNIFESP]; McKee, Marc D. (Wiley-Blackwell, 2013-03-01)
      X-linked hypophosphatemia (XLH/HYP)with renal phosphate wasting, hypophosphatemia, osteomalacia, and tooth abscessesis caused by mutations in the zinc-metallopeptidase PHEX gene (phosphate-regulating gene with homologies ...