Browsing by Subject "PAR-2"

Now showing items 1-3 of 3

    • Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice 

      Costa, R.; Marotta, D. M.; Manjavachi, M. N.; Fernandes, E. S.; Lima-Garcia, J. F.; Paszcuk, A. F.; Quintao, N. L. M.; Juliano, Luiz [UNIFESP]; Brain, S. D.; Calixto, J. B. (Wiley-Blackwell, 2008-07-01)
      Background and purpose: We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of neurogenic inflammation components in this response.Experimental approach: ...

    • Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw 

      Paszcuk, Ana Flavia; Quintao, Nara L. M.; Fernandes, Elizabeth S.; Juliano, Luiz [UNIFESP]; Chapman, Kevin; Andrade-Gordon, Patricia; Campos, Maria Martha; Vergnolle, Nathalie; Calixto, Joao B. (Elsevier B.V., 2008-02-26)
      It has been demonstrated that trypsin is able to evoke the classical signals of inflammation, mainly via the activation of proteinase-activated receptor-2 (PAR-2). This study was designed to evaluate the inflammatory and ...

    • The role of kinin B-1 and B-2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice 

      Costa, Robson; Manjavachi, Marianne N.; Motta, Emerson M.; Marotta, Denise M.; Juliano, Luiz [UNIFESP]; Torres, Hugo Arruda de Moura [UNIFESP]; Pesquero, João Bosco [UNIFESP]; Calixto, Joao B. (Wiley-Blackwell, 2010-02-01)
      Background and purpose:Activation of the proteinase-activated receptor-2 (PAR-2) induces scratching behaviour in mice. Here, we have investigated the role of kinin B-1 and B-2 receptors in the pruritogenic response elicited ...