Browsing by Subject "Neuroprotection"
Now showing items 1-10 of 19
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The A(1) receptor agonist R-Pia reduces the imbalance between cerebral glucose metabolism and blood flow during status epilepticus: Could this mechanism be involved with neuroprotection?
(Elsevier B.V., 2011-01-01)It is well known that the uncoupling between local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF), i.e. decrease in LCBF rates with high LCGU, is frequently associated with seizure-induced neuronal ...
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Avaliação do efeito da administração de Alfacetoglutarato e Glutamina sobre a sobrevida neuronal após a isquemia encefálica global transitória em ratos
(Universidade Federal de São Paulo (UNIFESP), 2019-12-16)One of the neurochemical events leading to neuronal death after brain ischemia is the elevation of ammonia concentration, in which detoxification occurs through its incorporation into the alpha-ketoglutarate (Krebs Cycle ...
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Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions
(Elsevier B.V., 2014-05-01)Several lines of evidences have shown the inversion association between coffee consumption and Parkinson's disease (PD) development. Caffeine is a methylxanthine known as a non-selective inhibitor of A2A and A1 adenosine ...
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Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise
(Elsevier B.V., 2013-11-15)The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. in the exercised EAE mice, although there was no effect ...
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Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus
(Elsevier B.V., 2011-10-01)Aiming at a better understanding of the role of A(2A) in temporal lobe epilepsy (TLE), we characterized the effects of the A(2A) antagonist SCH58261 (7-(2-phenylethyl)-5-amino-2(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c] ...
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Efeito protetor do extrato da planta Lippia grata e seu constituinte limoneno complexados com β-ciclodextrina em um modelo animal progressivo da doença de Parkinson.
(Universidade Federal de São Paulo, 2022-01-31)A doença de Parkinson (DP) é o transtorno do movimento relacionado a idade mais comum e é caracterizada pela degeneração de neurônios dopaminérgicos na substância negra parte compacta (SNpc) e pelo acúmulo de agregados ...
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Efeitos da administração crônica do extrato de casca de uva em camundongos submetidos a um modelo progressivo da Doença de Parkinson
(Universidade Federal de São Paulo (UNIFESP), 2020-07-21)Parkinson's disease (PD) is a neurodegenerative disease affecting mainly the elderly population. PD etiology remains unknown, however, evidence shows that genetic predisposition and environmental factors, such as contamination ...
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Efeitos do óleo essencial da folha de Eplingiella fruticosa complexado com β-ciclodextrina em um modelo animal da doença de Alzheimer induzido por estreptozotocina
(Universidade Federal de São Paulo, 2023-01-11)A doença de Alzheimer (DA) é a causa mais comum de demência em idosos. Estudos prévios têm apontado uma deficiência precoce no metabolismo da glicose encefálica e na via de sinalização da insulina como possíveis ...
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Estudo da ação da lovastatina no desenvolvimento do modelo experimental de epilepsia induzido pela pilocarpina em ratos
(Universidade Federal de São Paulo (UNIFESP), 2011-06-29)Introduction: Inflammation has been associated with several neurodegenerative diseases and experimental and clinical data suggest a crucial role in inflammatory processes in the development of epilepsy, particularly in ...
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Favorable effects of physical activity for recovery in temporal lobe epilepsy
(Wiley-Blackwell, 2010-01-01)P>Strategies that are efficacious for preventing or treating of epilepsy have been extensively used. This review discusses the positive effects of physical exercise program in experimental models of epilepsy, and considerations ...
