Now showing items 1-10 of 13

    • Aspectos Moleculares Envolvidos Na Nefrotoxicidade Induzida Pela Cisplatina 

      Estrela, Gabriel Rufino [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2017-05-31)
      Cisplatin is one of the antitumor agents most commonly used in chemotherapy, but nephrotoxicity is frequent and one of the limitations of its use. There are several mechanisms that contribute to renal dysfunction following ...

    • Bothropoides insularis venom cytotoxicity in renal tubular epithelia cells 

      Mello, Clarissa P.; Morais, Isabel C. O.; Menezes, Ramon R. P. P. B.; Pereira, Gustavo J. S. [UNIFESP]; Torres, Alba F. C.; Lima, Danya B.; Pereira, Ticiana P.; Toyama, Marcos H.; Monteiro, Helena S. A.; Smaili, Soraya Soubhi [UNIFESP]; Martins, Alice M. C. (Elsevier B.V., 2014-09-15)
      Bothropoides insularis (jararaca-ilhoa) is a native endemic snake limited to the specific region of Queimada Island, on São Paulo coast. Several local and systemic effects have been described due to envenomation caused by ...

    • Bothrops leucurus venom induces nephrotoxicity in the isolated perfused kidney and cultured renal tubular epithelia 

      Oliveira de Morais, Isabel Cristina; Costa Torres, Alba Fabiola; Silva Pereira, Gustavo Jose da [UNIFESP]; Pereira, Ticiana Praciano; Pessoa Bezerra de Menezes, Ramon Roseo de Paula; Mello, Clarissa Perdigao; Coelho Jorge, Antonio Rafael; Binda, Alexandre Havt; Toyama, Marcos Hikari; Azul Monteiro, Helena Serra; Smaili, Soraya Soubhi [UNIFESP]; Costa Martins, Alice Maria (Elsevier B.V., 2013-01-01)
      Bites from snake (Bothrops genus) cause local tissue damage and systemic complications, which include alterations such as hemostatic system and acute renal failure (ARF). Recent studies suggest that ARF pathogenesis in ...

    • Efeito da lectina de Dioclea violacea na lesão renal aguda induzida pela gentamicina 

      Leme, Ala Moana [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2019-10-31)
      Acute kidney injury (AKI) is characterized by the abrupt decline in glomerular filtration rate (GFR) that can be caused by sepsis, burn, hemorrhage or nephrotoxic substances such as the aminoglycoside gentamicin (Genta) ...

    • Estudo de associação entre polimorfismos dos genes ERCC1 e ABCB1 e nefro-hepatotoxicidade à quimioterapia com Paclitaxel/Carboplatina em pacientes com câncer ginecológico 

      Costa Junior, Luiz Carlos Da [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2020-03-05)
      Background: Paclitaxel/carboplatin combination is the standard chemotherapeutic protocol for gynecological cancers, but severe toxicities such as nephro and hepatotoxicity may compromise treatment. There is great interindividual ...

    • Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice 

      Damiao, Marcio Jose [UNIFESP]; Giannocco, Gisele [UNIFESP]; Grespan, Renata; Silva, Expedito Leite; Duarte, Janaina S. [UNIFESP]; Maciel, Rui Monteiro de Barros [UNIFESP]; Yamada, Alcileia Nunes; Bersani-Amado, Ciomar Aparecida; Cuman, Roberto Kenji Nakamura (Pharmacotherapy Group, 2013-12-01)
      Purpose: To investigate the effect of ginger essential oil (GEO) in an experimental model of cisplatin-induced nephrotoxicity.Methods: Male mice were divided into treatment six groups (n = 7), namely: Groups I (saline), ...

    • Kinin B1 receptor deficiency attenuates cisplatin-induced acute kidney injury by modulating immune cell migration 

      Estrela, Gabriel R. [UNIFESP]; Wasinski, Frederick [UNIFESP]; Almeida, Danilo C. [UNIFESP]; Amano, Mariane T.; Castoldi, Angela; Dias, Carolina C. [UNIFESP]; Malheiros, Denise M. A. C.; Almeida, Sandro S. [UNIFESP]; Paredes-Gamero, Edgar J. [UNIFESP]; Pesquero, Joao B. [UNIFESP]; Barros, Carlos C. [UNIFESP]; Camara, Niels O. S.; Araujo, Ronaldo C. [UNIFESP] (Springer, 2014-04-01)
      Cisplatin is a chemotherapeutic agent that causes severe renal dysfunction. the kinin B1 receptor has been associated with the migration of immune cells to injured tissue as well as with renal inflammation. To examine the ...

    • Mycophenolate Mofetil Initiation in Renal Transplant Patients at Different Times Posttransplantation: the TranCept Switch Study 

      Meier-Kriesche, Herwig-Ulf; Merville, Pierre; Tedesco-Silva, Helio [UNIFESP]; Heemann, Uwe; Kes, Petar; Haller, Hermann; Rostaing, Lionel; Gafner, Nesrin; Bernasconi, Corrado (Lippincott Williams & Wilkins, 2011-05-15)
      Background. Despite evidence of favorable long-term effects of mycophenolate mofetil (MMF) in renal transplantation, its introduction at different times posttransplant has not been studied in large cohorts.Methods. ...

    • Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity 

      Kusma, J.; Chaim, O. M. [UNIFESP]; Wille, A. C. M.; Ferrer, V. P.; Sade, Y. B.; Donatti, L.; Gremski, W.; Mangili, O. C.; Veiga, S. S. (Elsevier B.V., 2008-11-01)
      Bites from brown spiders (Loxosceles genus) have clinical manifestations including skin necrosis with gravitational spreading, and systemic involvement that may include renal failure, hemolysis, and thrombocytopenia. Mice ...

    • Nitric oxide (NO) is associated with gentamicin (GENTA) nephrotoxicity and the renal function recovery after suspension of GENTA treatment in rats 

      Christo, Joelma Santina [UNIFESP]; Rodrigues, Adelson Marçal [UNIFESP]; Mouro, Margaret Gori [UNIFESP]; Cenedeze, Marcos Antonio [UNIFESP]; Simoes, Manuel de Jesus [UNIFESP]; Schor, Nestor [UNIFESP]; Suemitsu Higa, Elisa Mieko [UNIFESP] (Elsevier B.V., 2011-03-15)
      GENTA nephrotoxicity is likely to be caused, among other factors, by an increase of vasoconstrictors or a decrease of vasodilators such as NO. Few days after discontinuing GENTA treatment, the renal function is recovered, ...