Now showing items 1-10 of 18

    • Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma 

      Duch, Cibele Repele [UNIFESP]; Figueiredo, Maria Stella [UNIFESP]; Ribas, Christian [UNIFESP]; Almeida, Manuella de Souza Sampaio [UNIFESP]; Colleoni, Gisele Wally Braga [UNIFESP]; Bordin, Jose Orlando [UNIFESP] (Associação Brasileira de Divulgação Científica, 2007-02-01)
      It is well established that interleukin-6 (IL-6) is an essential growth factor for multiple myeloma (MM) and patients with increased IL-6 levels have a poor prognosis. In healthy subjects, the presence of the C allele at ...

    • ANKHD1 regulates cell cycle progression and proliferation in multiple myeloma cells 

      Dhyani, Anamika; Duarte, Adriana S. S.; Machado-Neto, Joao A.; Favaro, Patricia [UNIFESP]; Ortega, Manoela Marques; Saad, Sara T. Olalla (Elsevier B.V., 2012-12-14)
      ANKHD1 is a multiple ankyrin repeat containing protein, highly expressed in cancers, such as acute leukemia. the present study was undertaken to determine the expression and functional significance of ANKHD1 in human ...

    • ANKHD1 represses p21 (WAF1/CIP1) promoter and promotes multiple myeloma cell growth 

      Dhyani, Anamika; Machado-Neto, Joao A.; Favaro, Patricia [UNIFESP]; Olalla Saad, Sara T. (Elsevier B.V., 2015-01-01)
      ANKHD1 (Ankyrin repeat and KH domain-containing protein 1) is highly expressed and plays an important role in the proliferation and cell cycle progression of multiple myeloma (MM) cells. ANKHD1 downregulation modulates ...

    • Anti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients 

      de Oliveira, Mariana B. [UNIFESP]; Fook-Alves, Veruska L. [UNIFESP]; Eugenio, Angela I. P. [UNIFESP]; Fernando, Rodrigo C. [UNIFESP]; Sanson, Luiz Felipe G. [UNIFESP]; de Carvalho, Mariana F. [UNIFESP]; Braga, Walter M. T. [UNIFESP]; Davies, Faith E.; Colleoni, Gisele W. B. [UNIFESP] (Elsevier Ireland Ltd, 2017)
      JAK proteins have been linked with survival and proliferation of multiple myeloma (MM) cells

    • Caracterização imunofenotípica das células plasmáticas em pacientes portadores de mieloma múltiplo 

      Leite, Luiz Arthur Calheiros [UNIFESP]; Almeida, Manuela S.; Kimura, Elisa S. [UNIFESP]; Bigonha, Jandey G. [UNIFESP]; Colleoni, Gisele Wally Braga [UNIFESP]; Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]; Yamamoto, Mihoko [UNIFESP] (Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia, 2010-08-01)
      INTRODUCTION AND OBJECTIVE: Multiple myeloma is an incurable malignancy characterized by the proliferation of a single clone of plasma cells in bone marrow. The aim of this study was to evaluate the frequency and prognostic ...

    • Efficacy and safety of bortezomib, thalidomide, and lenalidomide in multiple myeloma: An overview of systematic reviews with meta-analyses 

      Aguiar, Patricia Melo; Lima, Tacio de Mendonca; Braga Colleoni, Gisele Wally [UNIFESP]; Storpirtis, Silvia (Elsevier Science Inc, 2017)
      This overview summarizes evidence for the efficacy and safety of bortezomib, thalidomide, and lenalidomide in patients with multiple myeloma. We searched the Medline, Scopus, and LILACS databases through August 2016, ...

    • Elevada incidência de anormalidades cromossômicas numéricas detectadas por FISH multicentromérico em pacientes com mieloma múltiplo 

      Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]; Ribeiro Jr., Aníbal [UNIFESP]; Yamamoto, Mihoko [UNIFESP]; Rodrigues, Maria Madalena; Almeida, Manuella S. S. [UNIFESP]; Ribas, Christian [UNIFESP]; Calheiros, Luis A. [UNIFESP]; Colleoni, Gisele Wally Braga [UNIFESP] (Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia, 2007-02-01)
      This study aimed to characterize genetic alterations by interphase multicentromeric FISH focusing on chromosomal numerical abnormalities and using some locus specific probes for the most frequent aberrations found in the ...

    • Expression of adhesion molecules on CD34+ cells from steady-state bone marrow before and after mobilization and their association with the yield of CD34+ cells 

      Cecyn, Karin Zattar [UNIFESP]; Kimura, Eliza Yuriko Sugano [UNIFESP]; Lima, Dulce Marta S. M. [UNIFESP]; Yamamoto, Miyoko [UNIFESP]; Bordin, Jose Orlando [UNIFESP]; Oliveira, José Salvador Rodrigues de [UNIFESP] (Korean Soc Hematology, 2018)
      Background Cell adhesion molecules (CAMs) expressed on hematopoietic progenitor cells (HPCs), endothelial cells, and stromal cells play a pivotal role in the mobilization of CD34+ cells. Herein, we conducted a non-randomized ...

    • Expression of eight genes of nuclear factor-kappa B pathway in multiple myeloma using bone marrow aspirates obtained at diagnosis 

      Almeida, Manuella de Souza Sampaio [UNIFESP]; Vettore, Andre Luiz [UNIFESP]; Yamamoto, Mihoko [UNIFESP]; Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]; Zago, Marco Antonio; Colleoni, Gisele Wally Braga [UNIFESP] (F Hernandez, 2009-08-01)
      Purpose: To evaluate the expression of NF-kappa B pathway genes in total bone marrow samples obtained from MM at diagnosis using real-time quantitative PCR and to evaluate its possible correlation with disease clinical ...

    • FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4(+) T regulatory cells 

      Tobias Braga, Walter Moises [UNIFESP]; Silva, Bruna Raphaeli da [UNIFESP]; Carvalho, Ana Carolina de [UNIFESP]; Maekawa, Yumi Hasegawa; Bortoluzzo, Adriana Bruscato; Rizzatti, Edgar Gil; Atanackovic, Djordje; Braga Colleoni, Gisele Wally [UNIFESP] (Springer, 2014-11-01)
      Multiple myeloma (MM) development involves a series of genetic abnormalities and changes in the bone marrow (BM) microenvironment, favoring the growth of the tumor and failure of local immune control. T regulatory (Treg) ...