Browsing by Subject "Methotrexate"

Now showing items 1-10 of 13

    • Avaliação histopatológica hepática e renal de ratos expostos a drogas antineoplásicas em concentração ambientalmente relevantes 

      Aranha, Maria Luiza Garcia [UNIFESP] (Universidade Federal de São Paulo, 2023-07-04)
      O câncer é uma das doenças que mais afeta pessoas no mundo, sendo estimados cerca de 18,1 milhões novos casos no ano de 2020. Consequentemente, o consumo de medicamentos destinados ao tratamento dessa doença tem aumentado ...

    • Critérios preditores para o sucesso do tratamento da gravidez tubária íntegra com dose única de metotrexato 

      Soares, Roberto da Costa [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2006)
      OBJETIVO: Avaliar critérios preditores do sucesso terapêutico da gravidez ectópica com metotrexate. PACIENTES E MÉTODO: Estudo observacional longitudinal com 65 pacientes com gravidez tubária íntegra, submetidas ao tratamento ...

    • Development and validation of HPLC method to determination of Methotrexate in children oncologic patients 

      De Abreu, C. C.; Pires Rosa, P. C.; Da Costa Aguiar Alves, B.; Azzalis, Ligia Ajaime [UNIFESP]; De Souza Gehrke, F.; Pereira, E. C. [UNIFESP]; Junqueira, Virginia Berlanga Campos [UNIFESP]; Perazzo, Fabio Ferreira [UNIFESP]; Fonseca, Fernando Luiz Affonso [UNIFESP] (Verduci Publisher, 2015-04-01)
      OBJECTIVE: The acute lymphocytic leukemia is a hematopoietic cancer that occurs predominantly in children. Methotrexate is one of the most useful drugs in cancer chemotherapy. The aim of the study was to develop and validate ...

    • Eventos adversos do tratamento medicamentoso de pacientes com doenças reumáticas autoimunes na infância: uma coorte retrospectiva em centro único 

      Said, Manar [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2018-03-08)
      Introduction: Autoimmune rheumatic diseases (AIRDs) are inflammatory diseases caused by changes in the immune system, and are manifested by joint involvement, as well as involvement of other organs and systems. Treatment ...

    • Evolução dos níveis de beta-hCG após tratamento sistêmico da gravidez ectópica íntegra 

      Elito Junior, Julio [UNIFESP]; Nakamura, Mary Uchiyama [UNIFESP]; Camano, L. [UNIFESP] (Associação Médica Brasileira, 1998-03-01)
      OBJECTIVE: The follow-up of this treatment is done by monitorization of beta-hCG titers. The objective of this study is to evaluate the beta-hCG titers after treatment with MTX. METHODS:. Twenty four women were included ...

    • Giant cell arteritis: a multicenter observational study in Brazil 

      Souza, Alexandre Wagner Silva de [UNIFESP]; Okamoto, Karine Yoshiye Kajiyama [UNIFESP]; Abrantes, Fabiano [UNIFESP]; Schau, Bruno; Bacchiega, Ana Beatriz Santos; Shinjo, Samuel Katsuyuki [UNIFESP] (Faculdade de Medicina / USP, 2013-01-01)
      OBJECTIVE: To describe demographic features, disease manifestations and therapy in patients with giant cell arteritis from referral centers in Brazil. METHODS: A retrospective cohort study was performed on 45 giant cell ...

    • Gravidez ectópica não rota: diagnóstico e tratamento. Situação atual 

      Elito Junior, Julio [UNIFESP]; Montenegro, Nuno Aires Mota De Mendonça; Soares, Roberto Da Costa [UNIFESP]; Camano, Luiz [UNIFESP] (Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2008-03-01)
      It is advisable to do the non-invasive diagnosis of ectopic pregnancy precociously, before there is the tube rupture, combining for that the transvaginal ultrasonography with the dosage of the b-fraction of the chorionic ...

    • Índice orientador do tratamento sistêmico da gravidez ectópica íntegra com dose única de metotrexato 

      Elito Junior, Julio [UNIFESP]; Reichmann, André [UNIFESP]; Nakamura, Mary Uchiyama [UNIFESP]; Camano, Luiz [UNIFESP] (Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 1998-04-01)
      A prospective study was performed with 42 patients with unruptured ectopic pregnancy, which intended to elaborate an index to orient the systemic treatment with the administration of a single intramuscular dose of methotrexate ...

    • Methotrexate for ectopic pregnancy: when and how 

      Cecchino, Gustavo Nardini [UNIFESP]; Araujo Junior, Edward [UNIFESP]; Elito Junior, Julio [UNIFESP] (Springer, 2014-09-01)
      Ectopic pregnancy is the leading cause of maternal death in the first trimester of pregnancy. the dosage of beta fraction of human chorionic gonadotropin (beta-hCG) and improvement of the transvaginal ultrasound allowed ...

    • Molecular modeling approach to predict a binding mode for the complex methotrexate-carboxypeptidase G(2) 

      Turra, Kely Medeiros; Mesquita Pasqualoto, Kerly Fernanda; Ferreira, Elizabeth Igne; Rando, Daniela Goncales [UNIFESP] (Springer, 2012-05-01)
      Carboxypeptidase G(2) (CPG(2)) is a zinc-metalloenzyme employed in a range of cancer chemotherapy strategies by activating selectively nontoxic prodrugs into cytotoxic drugs in tumor as well as in the treatment of intoxication ...