Browsing by Subject "Methamphetamine"
Now showing items 1-10 of 13
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Assessment of tolerance to the effects of methamphetamine on daytime and nighttime activity evaluated with actigraphy in rhesus monkeys
(Springer, 2017)Methamphetamine is one of the most largely consumed illicit drugs, and its use is associated with abuse liability and several adverse health effects, such as sleep impairment. Importantly, sleep quality can influence ...
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Behavioral changes and brain energy metabolism dysfunction in rats treated with methamphetamine or dextroamphetamine
(Elsevier B.V., 2012-11-14)Studies have demonstrated that AMPHs produce long-term damage to the brain dopaminergic, serotoninergic and glutamatergic regions. Prefrontal cortex, amygdala, hippocampus and striatum appear to be involved in the toxicity ...
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Differences between dextroamphetamine and methamphetamine: behavioral changes and oxidative damage in brain of Wistar rats
(Springer, 2012-01-01)In this study methamphetamine (m-AMPH) and dextroamphetamine (d-AMPH) were compared to determine the potency of the two drugs on behavior and oxidative damage in brain of rats. Male adult Wistar rats were given single ...
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Efeito da inativação farmacológica da amídala na sensibilização contexto- específico induzida por metanfetamina em ratos
(Universidade Federal de São Paulo (UNIFESP), 2020-06-25)The amygdaloid complex, in particular, the basolateral and central, are considered structures related to associative learning processes related to negative and positive stimuli. Drug addiction involves associative learning ...
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Effects of cocaine, methamphetamine and modafinil challenge on sleep rebound after paradoxical sleep deprivation in rats
(Associação Brasileira de Divulgação Científica, 2008-01-01)Sleep loss is both common and critically relevant to our society and might lead to the abuse of psychostimulants such as amphetamines, cocaine and modafinil. Since psychoactive substance abuse often occurs within a scenario ...
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Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH
(Elsevier B.V., 2012-08-15)In the last years our research group has studied and validated the animal model of mania induced by dextroamphetamine (D-AMPH). Considering the lack of animal models of mania reported in the literature; this study evaluated ...
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Effects of methamphetamine self-administration on actigraphy-based sleep parameters in rhesus monkeys
(Springer, 2013-05-01)Sleep disorders and substance abuse are highly comorbid. Although methamphetamine is a very commonly abused drug, to the best of our knowledge, no study has evaluated its effects on sleep during drug use and abstinence ...
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Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys
(Springer, 2017)Accumulating evidence shows that the serotonergic system plays a major role in psychostimulant abuse through its interactions with the dopaminergic system. Studies indicate that serotonin 5-HT2C receptors are one of the ...
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Facilitation of ejaculation after methamphetamine administration in paradoxical sleep deprived rats
(Elsevier B.V., 2003-07-18)This study investigated the effects of methamphetamine (MA) on genital reflexes in paradoxical sleep deprived (PSD) rats. Different doses of MA (0, 4. 16 and 64 mg/kg) were acutely given after PSD or the equivalent time ...
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Fatores envolvidos no desenvolvimento e expressão da sensibilização comportamental ao efeito estimulante do modafinil e metanfetamina
(Universidade Federal de São Paulo (UNIFESP), 2010-04-28)The behavioral sensitization refers to the progressive increase of the stimulatory effect induced by repeated administration of drugs of abuse such as cocaine and amphetamine. Previous studies suggest that the environment ...
