Browsing by Subject "Metabolomics"
Now showing items 1-10 of 18
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Análise do perfil metabolômico do líquido folicular de pacientes com síndrome dos ovários policísticos submetidas ao tratamento de fertilização in vitro
(Universidade Federal de São Paulo (UNIFESP), 2017-03-28)Objectives: Analyze the metabolomic profile of follicular fluid from patients with and without hyper response to controlled ovarian stimulation, associated or not with polycystic ovary syndrome (PCOS). Method: Follicular ...
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Aplicação da metabolômica multiplataforma (HPLC-MS, CE-MS E GC-MS) non-targeted em estudos biomédicos
(Universidade Federal de São Paulo (UNIFESP), 2019-12-18)Metabolomic’s application in biomedical studies is a field of health that has been gaining credibility due to obtaining relevant biochemical information about the physiological or pathological state of the organism. The ...
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Avaliação Clínica E Metabolômica Da Doença Do Enxerto Contra O Hospedeiro Aguda Em Pacientes Submetidos Ao Transplante De Células Tronco Hematopoéticas
(Universidade Federal de São Paulo (UNIFESP), 2017-11-16)Introduction: The main barrier to the success of hematopoietic stem cell transplantation (HSCT) is acute graft versus host disease (aGVHD). The risk factors for aGVHD are mainly clinical and can be improved if additional ...
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Caracterização de aminoácidos proteinogênicos em indivíduos com esquizofrenia baseados em Espectroscopia de RMN-1h: estudo piloto
(Universidade Federal de São Paulo (UNIFESP), 2019-03-15)Schizophrenia (SCZ) is a serious and disabling mental disorder. The diagnosis is based on syndromic manifestations, interviews and clinical examination of the patient's mental state. These parameters provide a reliable ...
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Características Clínicas, Angiográficas E Painel Metabólico Sanguíneo Periférico Associados Ao Desenvolvimento De Insuficiência Cardíaca Em Pacientes Submetidos À Angiografia Coronária No Estudo Murdock Horizonte 1
(Universidade Federal de São Paulo (UNIFESP), 2018-12-11)Background: Heart Failure Is A Common And Complex Clinical Syndrome That Leads To Significant Morbidity And Mortality. The Relationship Of Circulating Metabolites With The Development Of New Onset Heart Failure May Provide ...
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Características clínico-laboratoriais, análise mutacional do gene PIG-A e perfil metabolômico em pacientes com hemoglobinúria paroxística noturna
(Universidade Federal de São Paulo (UNIFESP), 2019-04-18)Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a disorder due to an acquired abnormality in the phosphatidylinositol glycan class A (PIG-A) gene. This leads to partial or complete absence of all GPI-linked ...
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Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice
(Academic Press Inc Elsevier Science, 2017)The mechanisms underlying the association between chronic psychological stress, development of metabolic syndrome (MetS), and behavioral impairment in obesity are poorly understood. The aim of the present study was to ...
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The effect of coffee intake on lysophosphatidylcholines: A targeted metabolomic approach
(Churchill Livingstone, 2017)Background & aim: Lysophosphatidylcholines (lysoPC) are known to be a pathological component of oxidized-LDL, and several studies demonstrate its pro-inflammatory properties in vitro. Nevertheless, bioactive compounds found ...
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Estudo da relação de metabólitos da rota de degradação da adenosina com doenças cardiovasculares por meio de ferramentas quimiométricas
(Universidade Federal de São Paulo, 2021-07-07)As doenças cardiovasculares (DCV) são consideradas as principais causas de óbitos no mundo. O Infarto Agudo do Miocárdio (IAM) e a aterosclerose são as formas mais relevantes de cardiopatia isquêmica, sendo seu diagnóstico ...
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Estudo de assinaturas metabólicas em leiomiomas uterinos
(Universidade Federal de São Paulo, 2022-07-12)Objective: The present study evaluated circulating metabolites in the plasma of patients with and without leiomyomas, to define a metabolomic profile of these patients and compare them according to leiomyomas' presence and ...
